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Mashup Score: 3
BACKGROUND: Pharmacological treatments for fibrocalcific aortic valve stenosis (FCAVS) have been elusive for >50 years. Here, we tested the hypothesis that reactivation of oxidized sGC (soluble guanylate cyclase), the primary receptor for nitric oxide, with ataciguat is a safe and efficacious strategy to slow progression of FCAVS. METHODS: We used quantitative real-time reverse transcription polymerase chain reaction, Western blotting, and immunohistochemistry to characterize sGC signaling and the biological effects of ataciguat on signaling cascades related to nitric oxide, calcification, and fibrosis in excised human aortic valve tissue, aortic valve interstitial cells, and mouse aortic valves. We then conducted randomized, placebo-controlled phase I (14-day safety/tolerance) and phase II (6-month efficacy) trials in patients with moderate aortic valve stenosis. RESULTS: In excised human tissue, we found robust losses in sGC signaling despite upregulation of sGC subunits. In vitro, a
Source: www.ahajournals.orgCategories: General Medicine NewsTweet
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Mashup Score: 55The Evolving Role of Colchicine in Coronary Atherosclerosis Management: Timing May Be Everything - American College of Cardiology - 9 day(s) ago
Colchicine is an anti-inflammatory drug approved by the Food and Drug Administration for reduction of cardiovascular risk. Low-dose colchicine has shown significant reduction in cardiovascular events in patients with chronic coronary artery disease. Defining the optimal timing of colchicine initiation after a myocardial infarction may better inform its role in reducing recurrent atherosclerotic cardiovascular events. Chronic inflammation plays a role in the pathogenesis of cardiovascular diseases,
Source: www.acc.orgCategories: General Medicine NewsTweet-
The Evolving Role of Colchicine in Coronary Atherosclerosis Management: Timing May Be Everything @ACCmediacenter @AAgarwalaMD @EugeniaGianos @DrEugeneYang @CiccaroneCenter @AbbateAntonio #cvPrev https://t.co/8KYSQAB6CC
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Mashup Score: 52The Evolving Role of Colchicine in Coronary Atherosclerosis Management: Timing May Be Everything - American College of Cardiology - 10 day(s) ago
Colchicine is an anti-inflammatory drug approved by the Food and Drug Administration for reduction of cardiovascular risk. Low-dose colchicine has shown significant reduction in cardiovascular events in patients with chronic coronary artery disease. Defining the optimal timing of colchicine initiation after a myocardial infarction may better inform its role in reducing recurrent atherosclerotic cardiovascular events. Chronic inflammation plays a role in the pathogenesis of cardiovascular diseases,
Source: www.acc.orgCategories: General Medicine NewsTweet-
The Evolving Role of Colchicine in Coronary Atherosclerosis Management: Timing May Be Everything @ACCmediacenter @AAgarwalaMD @EugeniaGianos @DrEugeneYang @CiccaroneCenter @AbbateAntonio #cvPrev https://t.co/8KYSQAB6CC
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Mashup Score: 0Cutting NIH funding isn’t how to defeat disease, it’s surrender - 1 month(s) ago
NIH is proof of America’s excellent research and many successes against our worst diseases from leukemia, and cystic fibrosis to heart disease and Alzheimer’s. We shouldn’t stop that.
Categories: General Medicine News, CardiologistsTweet-
https://t.co/Mc7a2t5cXN ‘Cutting NIH funding isn’t how to defeat disease, it’s surrender.’ @BaltBizOnline @HopkinsMedicine @HeartBobH
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Mashup Score: 11Tachycardia in Pregnancy - American College of Cardiology - 2 month(s) ago
A 32-year-old woman who is 14 weeks pregnant (gravida 1, para 0) presents with a 6-week history of exertional palpitations and fatigue. She reports severe palpitations that worsen with activity and are associated with lightheadedness and fatigue. She experiences significant palpitations on standing after lying down for a while. The palpitations improve with lying flat. Her symptoms have significantly limited her level of activity. Her pregnancy has otherwise been uneventful except for nausea and vomiting
Source: www.acc.orgCategories: General Medicine News, CardiologistsTweet-
Tachycardia in Pregnancy - @ACCinTouch @ACCmediacenter @ACCMaryland @ACCVirginia @ISHVnews @CiccaroneCenter Nice patient vignette/management recommendations - @ykjohnson07 @GarimaVSharmaMD https://t.co/8UBGh4LaA8
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Mashup Score: 11Top ACC Content in 2024 - American College of Cardiology - 4 month(s) ago
What an amazing year 2024 was in terms of advances in cardiovascular care! With more than 882,000 users, ACC.org continues to be a critical resource for cardiovascular clinicians around the world! The most visited journal scan articles of 2024 reflected areas of major progress or new understandings of conditions and/or their treatment. SGLT2 inhibitors and GLP-1 RAs are transforming our treatment of heart failure, diabetes and obesity. More precise care of acute and chronic coronary artery disease is
Source: www.acc.orgCategories: General Medicine News, CardiologistsTweet-
Nice to see that a few of the Top 1️⃣0️⃣ #ExpertAnalyses from @ACCinTouch this year are from the #cvPrev section!! Check it out! Thanks to great leadership from @DrEugeneYang @EugeniaGianos @AAgarwalaMD @keaglemd @seamuswhelton @SuvasiniL and team. https://t.co/xc4rty34Ii
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Mashup Score: 5
Now is a moment ripe for change
Source: www.medpagetoday.comCategories: General Medicine News, CardiologistsTweet-
Insurers Are Dictating Care and We're Sick, Sick, Sick of It! @ERDocBrown @medpagetoday https://t.co/TjPnczxgor
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Mashup Score: 1Lung CT Can Detect Coronary Artery Disease, Predict Death - 4 month(s) ago
Lung cancer screening with low-dose CT can detect extensive coronary artery calcium, an independent predictor of all-cause death and cardiovascular events.
Source: www.medscape.comCategories: General Medicine News, CardiologistsTweet-
Lung CT Can Detect Coronary Artery Disease, Predict Death @Medscape https://t.co/Hwma4pqCIx
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Mashup Score: 9
Garima Sharma, MBBS, FACC
Source: www.acc.orgCategories: General Medicine News, CardiologistsTweet-
Risk of MI After Pregnancy with Hypertension. @GarimaVSharmaMD @ACCmediacenter @ISHVnews https://t.co/E8lpCyiVm3
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Mashup Score: 14Abstract 4141747: The OurHealth Study: A Decentralized Biobank of South Asian Americans | Circulation - 5 month(s) ago
Introduction: South Asians living in the United States (SAUS) experience greater cardiovascular disease (CVD) events compared to most other racial and ethnic groups. Limited representation and collection of relevant community-specific identity, health, lifestyle, and exposure factors in studies to date have impeded understanding of this elevated risk. To address these scientific gaps, the OurHealth study was devised as a scalable national biobank of SAUS populated with demographic, health, and genetic data. Aims: The primary objectives of OurHealth are to discover South Asian-specific genomic and non-genomic risk factors for CVD and serve as a reliable resource of culturally appropriate information for cardiovascular health. Methods: OurHealth is enabled by the study platform website (https://ourhealthstudy.org), recruiting adult individuals who (1) identify with South Asian ancestry, (2) are comfortable reading or speaking English, and (3) live in the US. Recruitment efforts include s
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
RT @shriieganesh: Very excited to present the @ourhealthstudy and talk about South Asian CVD risk at #AHA24!! https://t.co/zYgpyhnoOy http…
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Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis: Preclinical and Randomized Clinical Trials to Assess Safety and Efficacy @CircAHA https://t.co/jRkfhsGqjS