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Mashup Score: 6
Nature Communications – HIV exposed but uninfected infants may face an increased risk of serious infection and mortality. In this work, the authors utilise a cohort from rural Zimbabwe to explore…
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 2SARS-CoV-2 nsp15 preferentially degrades AU-rich dsRNA via its dsRNA nickase activity - 20 day(s) ago
Abstract. It has been proposed that coronavirus nsp15 mediates evasion of host cell double-stranded (ds) RNA sensors via its uracil-specific endoribonuclea
Source: academic.oup.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 2Medicine Researcher Spotlight - Lee Quinton, PhD - 21 day(s) ago
Researcher Spotlight for Lee Quinton, PhD
Source: www.umassmed.eduCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 3Myeloid C-type lectin receptors in innate immune recognition - 23 day(s) ago
C-type lectin receptors (CLRs) comprise a vast family of proteins, several of which play key roles in the immune system. In this article, Reis e Sousa et al. review the biology of CLRs expressed by myeloid cells and their role in innate immune responses to infection, commensal organisms, and tissue injury or dysfunction.
Source: www.cell.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 1Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response - 26 day(s) ago
Non-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic diarrhea virus (PED…
Source: www.tandfonline.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 2New drug prevents flu-related inflammation and lung damage - 28 day(s) ago
Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.
Source: www.eurekalert.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 8
Nature Immunology – Here the authors identify the transcription factor MEF2C as essential for human NK cell function and viral immunity in mice and humans. This control is exerted via regulation of…
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 9LC3B conjugation machinery promotes autophagy-independent HIV-1 entry in CD4+ T lymphocytes - 1 month(s) ago
HIV-1 entry into CD4+ T lymphocytes relies on the viral and cellular membranes’ fusion, leading to viral capsid delivery in the target cell cytoplasm. Atg8/LC3B conjugation to lipids, process named…
Source: www.tandfonline.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 6Prior infection with unrelated neurotropic virus exacerbates influenza disease and impairs lung T cell responses - 1 month(s) ago
Nature Communications – Co-infections are much less studied than single pathogen infections. Here, the authors show that co-infection with two unrelated viruses, neurotropic Semliki Forest virus…
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 6Establishment of a human organoid-based evaluation system for assessing interspecies infection risk of animal-borne coronaviruses - 1 month(s) ago
The COVID-19 pandemic presents a major threat to global public health. Several lines of evidence have shown that the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), along with two oth…
Source: www.tandfonline.comCategories: General Medicine News, Infectious DiseaseTweet-
Investigators used #organoid technology as a new model for studying emerging pathogens and their mechanisms. They investigated the key 🔑 host-virus interaction patterns of five human #coronaviruses in different human respiratory organoids. @JournalEMI | https://t.co/gaXUS7YMrv https://t.co/uhqZ8syz8U
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🤰 A collaboration between @QMUL and @ZvitamboZim demonstrates how the #pregnancy immune environment in women with #HIV underlies mortality and immune development in their offspring in a sex-differentiated manner. https://t.co/HEQZGdzGob https://t.co/CfsEEGgGJA