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Mashup Score: 0
Dengue fever is a viral infection caused by the dengue virus, which contributes to tens of thousands of deaths annually. Endemic to tropical and subtropical regions, dengue virus is transmitted by Aedes mosquitoes that breed in warm stagnant waters. Upon biting a susceptible host, the virus is transferred to the bloodstream, leading, in most people, to fever and vomiting. At its worst, dengue virus can lead to internal bleeding and death. As an arbovirus (ie, an arthropod-borne virus), the number of dengue-virus infections in an area are often closely linked to mosquito breeding habits, leading to a cyclical pattern of widespread transmission spanning 3–4 years.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0
Dengue fever is a viral infection caused by the dengue virus, which contributes to tens of thousands of deaths annually. Endemic to tropical and subtropical regions, dengue virus is transmitted by Aedes mosquitoes that breed in warm stagnant waters. Upon biting a susceptible host, the virus is transferred to the bloodstream, leading, in most people, to fever and vomiting. At its worst, dengue virus can lead to internal bleeding and death. As an arbovirus (ie, an arthropod-borne virus), the number of dengue-virus infections in an area are often closely linked to mosquito breeding habits, leading to a cyclical pattern of widespread transmission spanning 3–4 years.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 20Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer’s pathology - 12 day(s) ago
Both p-tau217 assays had excellent diagnostic performance for AD. Our study supports the future clinical use of commercially-available assays for p-tau217.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 20Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer’s pathology - 12 day(s) ago
Both p-tau217 assays had excellent diagnostic performance for AD. Our study supports the future clinical use of commercially-available assays for p-tau217.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 10A 14-gene B-cell immune signature in early-stage triple-negative breast cancer (TNBC): a pooled analysis of seven studies - 13 day(s) ago
IGG is linked to improved prognosis and pCR in early-stage TNBC. The integration of IGG alongside tumor and nodal staging holds promise as an approach to identify patients benefitting from intensified or de-intensified treatments.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
Editor pick from April issue @BenedettaConte5 @prat_aleix @fara_bm & coll Identified a 14-gene immunoglobulin B-cell signature linked to improved prognosis and pathological complete response in patients with early-stage triple-negative breast cancer Read https://t.co/c0A6tK9n8e https://t.co/oIqxxSMkbE
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Mashup Score: 0Peripheral amyloid-β clearance mediates cognitive impairment in non-alcoholic fatty liver disease - 16 day(s) ago
LRP-1 mediates the adverse effect of NAFLD on peripheral Aβ clearance, thereby contributing to cerebral Aβ accumulation and cognitive impairment in NAFLD.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0The performance of 11 fingertip pulse oximeters during hypoxemia in healthy human participants with varied, quantified skin pigment - 18 day(s) ago
Fingertip pulse oximeters have variable performance, frequently not meeting regulatory requirements for clinical use, and occasionally contradicting claims made by manufacturers. Most devices showed a trend toward worse performance in participants with darker skin pigment. Regulatory standards do not adequately account for the impact of skin pigmentation on device performance. We recommend that the pFP and other non-standardised subjective skin colour scales should no longer be used for defining diversity of skin pigmentation.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0The performance of 11 fingertip pulse oximeters during hypoxemia in healthy human participants with varied, quantified skin pigment - 18 day(s) ago
Fingertip pulse oximeters have variable performance, frequently not meeting regulatory requirements for clinical use, and occasionally contradicting claims made by manufacturers. Most devices showed a trend toward worse performance in participants with darker skin pigment. Regulatory standards do not adequately account for the impact of skin pigmentation on device performance. We recommend that the pFP and other non-standardised subjective skin colour scales should no longer be used for defining diversity of skin pigmentation.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohort - 20 day(s) ago
This study confirms that FGF14 GAA expansions are a frequent cause of DBN syndromes. It provides preliminary evidence that (GAA)200-249 alleles might be pathogenic. Finally, it provides large real-world and preliminary piloting placebo-controlled evidence for the efficacy of 4-aminopyridine in GAA-FGF14 disease.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohort - 20 day(s) ago
This study confirms that FGF14 GAA expansions are a frequent cause of DBN syndromes. It provides preliminary evidence that (GAA)200-249 alleles might be pathogenic. Finally, it provides large real-world and preliminary piloting placebo-controlled evidence for the efficacy of 4-aminopyridine in GAA-FGF14 disease.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
April issue editorial Development of the understanding and induction of robust T-cell immunity could be crucial for effective and long-lasting #dengue virus vaccination. Read https://t.co/JZK2Wa4Lbd https://t.co/EDaiUStwR8