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Mashup Score: 5
Perioperative corticosteroids have shown potential as non-opioid analgesic adjuncts for various orthopedic pathologies, but there is a lack of research on their use in the postoperative setting after total shoulder arthroplasty (TSA). The purpose of this study was to assess the effect of a methylprednisolone taper on a multimodal pain regimen after TSA.
Source: www.jshoulderelbow.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 29Modafinil Treatment of Opioid-Induced Sedation - 2 day(s) ago
ABSTRACT. Study Objective. The purpose of this study was to assess the efficacy of modafinil in combating opioid-induced sedation.Design. A 1-year retrospe
Source: academic.oup.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 19
Academic Clinical Immunologist/Allergist or Clinical Pharmacologist
Source: jobs.utoronto.caCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4
American Journal of Cardiovascular Drugs – The renin–angiotensin–aldosterone system plays an important role in the pathophysiology of hypertension and is closely related with cardio-…
Source: link.springer.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 17Concentration-Dependent Mode of Interaction of Angiotensin II Receptor Blockers with Uric Acid Transporter - 1 month(s) ago
Serum uric acid (SUA) is currently recognized as a risk factor for cardiovascular disease. It has been reported that an angiotensin II receptor blocker (ARB), losartan, decreases SUA level, whereas other ARBs, such as candesartan, have no lowering effect. Because the renal uric acid transporter (URAT1) is an important factor controlling the SUA level, we examined the involvement of URAT1 in those differential effects of various ARBs on SUA level at clinically relevant concentrations. This study was done by using URAT1-expressing Xenopus oocytes. Losartan, pratosartan, and telmisartan exhibited cis -inhibitory effects on the uptake of uric acid by URAT1, whereas at higher concentrations, only telmisartan did, and these ARBs reduced the uptake in competitive inhibition kinetics. On the other hand, candesartan, EXP3174 [2- n -butyl-4-chloro-1-[(2′-(1 H -tetrazol-5-yl)biphenyl-4-yI)methyl]imidazole-5-carboxylic acid] (a major metabolite of losartan), olmesartan, and valsartan were not in
Source: jpet.aspetjournals.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 50Effect of the single CYP2C9*3 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects - 1 month(s) ago
European Journal of Clinical Pharmacology – Losartan is metabolized to the active carboxylic acid metabolite EXP3174 by CYP2C9. In this study, we determined the effects of the single CYP2C9*3…
Source: link.springer.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 45Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics - 1 month(s) ago
Acta Pharmacologica Sinica – Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics
Source: www.nature.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 71Regulation of Peroxisome Proliferator–Activated Receptor γ Activity by Losartan Metabolites - 1 month(s) ago
Two active metabolites of the angiotensin type 1 (AT1) receptor blocker losartan have been described previously, EXP3174 and EXP3179. Whereas EXP3174 is the main antihypertensive AT1 receptor–blockin
Source: www.ahajournals.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 60Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences - Human Genomics - 1 month(s) ago
Background Genetic variability in the cytochrome P450 CYP2C9 constitutes an important predictor for efficacy and safety of various commonly prescribed drugs, including coumarin anticoagulants, phenytoin and multiple non-steroidal anti-inflammatory drugs (NSAIDs). A global map of CYP2C9 variability and its inferred functional consequences has been lacking. Results Frequencies of eight functionally relevant CYP2C9 alleles (*2, *3, *5, *6, *8, *11, *13 and *14) were analyzed. In total, 108 original articles were identified that included genotype data from a total of 81,662 unrelated individuals across 70 countries and 40 unique ethnic groups. The results revealed that CYP2C9*2 was most abundant in Europe and the Middle East, whereas CYP2C9*3 was the main reason for reduced CYP2C9 activity across South Asia. Our data show extensive variation within superpopulations with up to tenfold differences between geographically adjacent populations in Malaysia, Thailand and Vietnam. Translation of g
Source: humgenomics.biomedcentral.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 55What's behind the stunning rise in alcohol-related deaths - 2 month(s) ago
Alcohol is one of the most commonly used drugs in America, and it is also one of the deadliest, with more and more people losing their lives to alcohol-related causes over the last two decades. A new report reveals how the problem has become more acute in recent years. Keith Humphreys, a professor of psychiatry and behavioral sciences at Stanford University, joins William Brangham to discuss.
Source: www.pbs.orgCategories: General Medicine News, General HCPsTweet
Take a look at what a few days of low-dose, tapering methylprednisolone does to pain and opioid consumption following shoulder surgery. https://t.co/3GNBXxoIu2 https://t.co/jJXClOeXtE