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Mashup Score: 11Gene-respiratory disease interactions for rheumatoid arthritis risk - 5 month(s) ago
We aimed to identify gene by respiratory tract disease interactions that increase RA risk.In this case-control study using the Mass General Brigham Bi…
Source: www.sciencedirect.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 2Assessing clusters of comorbidities in rheumatoid arthritis: a machine learning approach - Arthritis Research & Therapy - 6 month(s) ago
Background Comorbid conditions are very common in rheumatoid arthritis (RA) and several prior studies have clustered them using machine learning (ML). We applied various ML algorithms to compare the clusters of comorbidities derived and to assess the value of the clusters for predicting future clinical outcomes. Methods A large US-based RA registry, CorEvitas, was used to identify patients for the analysis. We assessed the presence of 24 comorbidities, and ML was used to derive clusters of patients with given comorbidities. K-mode, K-mean, regression-based, and hierarchical clustering were used. To assess the value of these clusters, we compared clusters across different ML algorithms in clinical outcome models predicting clinical disease activity index (CDAI) and health assessment questionnaire (HAQ-DI). We used data from the first 3 years of the 6-year study period to derive clusters and assess time-averaged values for CDAI and HAQ-DI during the latter 3 years. Model fit was assessed
Source: link.springer.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 3
In a recent study, participants had highest gout flare rates when serum urate levels were > 10 mg/dL and the lowest gout flare when levels were < 3.9 mg/dL.
Source: www.hcplive.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 3
In a recent study, participants had highest gout flare rates when serum urate levels were > 10 mg/dL and the lowest gout flare when levels were < 3.9 mg/dL.
Source: www.hcplive.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 0Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease - 6 month(s) ago
Asthma and chronic obstructive pulmonary disease (COPD) have distinct and overlapping genetic and clinical features.We sought to test the hypothesis t…
Source: www.sciencedirect.comCategories: General Medicine News, RheumatologyTweet-
#BWHRheumatology explores genetic risk scores for #asthma & spirometry in relation to asthma, #COPD, & overlapping conditions. Findings suggest both scores are assoc. w/ asthma-COPD overlap & exacerbations, but performance varies across different cohorts. https://t.co/FInyxiIHbV https://t.co/ZhjWEV1NIu
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Mashup Score: 0Public Insurance and Single-Guardian Households Are... : JBJS - 7 month(s) ago
ts of health. The purpose of this study was to evaluate the impact of insurance type, family structure, and neighborhood-level socioeconomic vulnerability on the delay of SCFE diagnosis. Methods: We reviewed medical records of patients who underwent surgical fixation for stable SCFE at a tertiary pediatric hospital from 2002 to 2021. We abstracted data on demographic characteristics, insurance status, family structure, home address, and symptom duration. We measured diagnostic delay in weeks from the date of symptom onset to diagnosis. We then geocoded patient addresses to determine their Census tract-level U.S. Centers for Disease Control and Prevention (CDC) and Agency for Toxic Substances and Disease Registry (ATSDR) Social Vulnerability Index (SVI), using U.S. Census and American Community Survey data. We performed 3 separate logistic regression models to examine the effects of (1) insurance status, (2) family structure, and (3) SVI on a delay of ≥12 weeks (reference, <12 weeks). W
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
#BWHRheumatology finds factors impacting delayed diagnosis in slipped capital femoral epiphysis (#SCFE). Pts w/ public insurance & from single-guardian households more likely to face ≥12 wks delay. Addressing disparities crucial for timely intervention. https://t.co/yi5UCdRrG9 https://t.co/I72geMgi2c
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Mashup Score: 0A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities - 7 month(s) ago
Rationale: In addition to rare genetic variants and the MUC5B locus, common genetic variants contribute to idiopathic pulmonary fibrosis (IPF) risk. The predictive power of common variants outside …
Source: www.atsjournals.orgCategories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology studied role of common genetic variants in identifying idiopathic pulmonary fibrosis (IPF) and interstitial lung abnormalities (ILA) risk. Polygenic risk scores (PRS) w/o MUC5B region associated w/ IPF, ILA, and ILA progression. https://t.co/3DUSXZnU4I #genetics https://t.co/Aaloi2FmBx
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Mashup Score: 7WCH Scientists Develop Tool Predicting Risk of Psoriatic Arthritis – A Global First - 8 month(s) ago
Psoriatic arthritis (PsA) is an inflammatory disease that affects the joints and muscles. In about 75 per cent of cases, PsA emerges after a person has been diagnosed with psoriasis…
Source: www.womenscollegehospital.caCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1Robert F. Kennedy Jr. press dinner explodes in war of words and farting - 10 month(s) ago
A verbal war broke out between two old-timers over climate change that led to one loudly farting at the table to express his disgust.
Source: Page SixCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0Comparative safety and effectiveness of TNF inhibitors, IL6 inhibitors and methotrexate for the treatment of immune checkpoint inhibitor-associated arthritis - 10 month(s) ago
Objectives To compare the safety and effectiveness of biologic and conventional disease-modifying antirheumatic drugs (DMARDs) for immune checkpoint inhibitor-associated inflammatory arthritis (ICI-IA). Methods The retrospective multicentre observational study included patients with a diagnosis of ICI-IA treated with a tumour necrosis factor inhibitor (TNFi), interleukin-6 receptor inhibitor…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet
#BWHRheumatology finds gene-respiratory tract disease interactions⬆️risk of #RheumatoidArthritis. High genetic risk scores & specific variants⬆️RA susceptibility. Synergistic relationships seen, informing potential strategies for RA prevention/screening. https://t.co/dCNrlt8Wsz https://t.co/KByxyDluHb