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Mashup Score: 7Cancer Research Early Career Award | Cancer Research | American Association for Cancer Research - 12 day(s) ago
Cancer Research Early Career Award | Cancer Research | American Association for Cancer Research .aacrcontent .banner{ width: 100% margin: -20px; } .aacrcontent .banner-sm{ display: none; } .right{float: right; margin: 0 16px 16px 16px; padding: 16px; width: 220px; background-color: #f0f0f0; border: solid 1px #ddd;} .aacrcontent2 { box-shadow: 3px 3px 6px #ccc, -3px -3px 6px #ccc; font-size: 16px; max-width: 400px; padding: 16px;} .copy h3{margin-top: 20px;} /*…
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 11Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer - 13 day(s) ago
Inhibition of p38 MAPK suppresses tumor cell–derived IL1α and attenuates the inflammatory stroma and immunosuppressive tumor microenvironment to overcome chemotherapeutic resistance in pancreatic cancer.
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Mashup Score: 7Breast Cancer Stem Cells Secrete MIF to Mediate Tumor Metabolic Reprogramming That Drives Immune Evasion - 13 day(s) ago
MIF secreted by breast cancer stem cells induces metabolic reprogramming in bulk tumor cells and engenders an immunosuppressive microenvironment, identifying MIF targeting as a strategy to improve immunotherapy efficacy in breast cancer.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 9ASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts - 13 day(s) ago
Analysis of residual disease following tyrosine kinase inhibitor treatment identified heterogeneous and context-specific mechanisms of drug tolerance in lung cancer that could lead to the development of strategies to forestall drug resistance.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0
Convergence Science | Cancer Research | American Association for Cancer Research .aacrcontent { display: flex; flex-direction: row; justify-content: space-between; align-items: stretch; } .intro { margin-top: 26px; font-size: 1.2em; } /* ****************** LEFT SIDE ****************** */ .left-side{ color: #000000; background-color: #fff; max-width: 710px; margin-right: 26px; } .left-side h3{ margin-bottom: 26px; } .node { line-height: 1.2em; margin-left: 12px; } .node2 {line-height: 1.0em; }…
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 30
Abstract. Pancreatic cancer prevalence increases with age, and disease prognosis is poorer in older individuals. The increased prevalence is driven, undoubtedly, by the multistep accumulation of oncogenic mutations in cancer cells with age. However, fibroblasts are major constituents and key players in pancreatic cancer, and they too undergo age-related changes that may contribute to disease severity. In this issue of Cancer Research, Zabransky and colleagues set out to dissect the effect of age-related changes in pancreatic fibroblasts on pancreatic ductal adenocarcinoma growth and metastasis. They discovered that aged fibroblasts secrete GDF-15, which in turn activates AKT signaling and accelerates tumor progression. These findings provide a mechanistic role for aged fibroblasts in pancreatic cancer, underpinning the importance of normal physiologic processes in tumor progression.See related article by Zabransky et al., p. 1221
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Mashup Score: 47
Aged pancreatic fibroblasts secrete GDF-15 and activate AKT signaling to promote pancreatic cancer growth, highlighting the critical role of aging-mediated changes in the pancreatic cancer microenvironment in driving tumor progression.
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Mashup Score: 20Exploiting Tertiary Lymphoid Structures to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy - 20 day(s) ago
Abstract. Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non–small cell lung cancer. Although the detailed cellular and molecular mechanisms underlying these clinical associations have not been fully elucidated, growing preclinical and clinical studies are helping to elucidate the mechanisms at the basis of TLS formation, composition, and regulation of immune responses. However, a major challenge remains how to exploit TLS to enhance naïve and treatment-mediated antitumor immune responses. Here, we discuss the current understanding of tumor-associated TLS, preclinical models that can be used to study them, and potential therapeutic interventions to boost TLS formation, with a particular focus on lung cancer research.
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Mashup Score: 4
Abstract. The intersection of precision medicine and artificial intelligence (AI) holds profound implications for cancer treatment, with the potential to significantly advance our understanding of drug responses based on the intricate architecture of tumor cells. A recent study by Park and colleagues titled
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Mashup Score: 6
Abstract. Metastasis arises from cancer-cell intrinsic adaptations and permissive tumor microenvironments (TME) that are distinct across different organs. Deciphering the mechanisms underpinning organotropism could provide novel preventive and therapeutic strategies for cancer patients. Rogava and colleagues identified Pip4kc as a driver of liver metastasis, acting by sensitizing cancer cells to insulin-dependent PI3K/AKT signaling, which could be reversed by dual pharmacological inhibition of PI3K and SGLT2 or a ketogenic diet. The study highlights the importance of tumor: microenvironment communication in the context of systemic physiology and points towards potential combination therapies.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
Congratulations to Salma Kaochar, PhD, MFA, recipient of the Cancer Research Early Career Award, which recognizes the outstanding contributions of #earlycareer investigators. Learn more about this award: https://t.co/i1hN1ArWzT @Kaochar2 @bcmhouston @BCMCancerCenter #AACR24 https://t.co/tzF0w5NIXd