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Mashup Score: 0
View all available purchase options and get full access to this article. Winkle RA, Mead RH, Engel G, Kong MH, Fleming W, Salcedo J, Patrawala RA. Impact of obesity on atrial fibrillation ablation: patient characteristics, long-term outcomes, and complications. Heart Rhythm. 2017;14:819–827. doi: 10.1016/j.hrthm.2017.02.023 Tonegawa-Kuji R, Nakai M, Kanaoka K, Sumita Y, Miyamoto Y, Kusano K, Iwanaga Y, Yamane T. Impact of low body mass index on cardiac tamponade during catheter ablation for atrial
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Mashup Score: 2
BACKGROUND: DSP cardiomyopathy is a distinct subset of arrhythmogenic cardiomyopathy, reported primarily in adults, that has predominantly left ventricular involvement and features of myocarditis. Clinical characteristics, risk stratification, and management of pediatric patients with DSP variants are not well known. We sought to identify phenotypic features and prognosis of pediatric patients with DSP pathogenic or likely pathogenic variants. METHODS: Multicenter, retrospective study of patients <21 years of age with DSP variants from 6 tertiary pediatric hospitals. RESULTS: Thirty-four patients, including 10 probands with clinical disease and 24 genotype-positive phenotype-negative patients, were included in the study. The majority of probands were initially diagnosed with myocarditis (50%) and had biventricular (60%) or left ventricular predominant (40%) disease. Chest pain was the most common symptom at presentation (30%), and all had troponin elevation. Probands with homozygous or
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Pediatric desmoplakin (DSP) cardiomyopathy has predominantly LV or BiV involvement and may present early with malignant VT and severe LV dysfunction #AHAJournals #Epeeps @villachet @Will_Goodyer https://t.co/u408pefbJx https://t.co/B8yaMoi80z
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Mashup Score: 63
BACKGROUND: Left bundle branch area pacing (LBBAP) may be an alternative to biventricular pacing (BVP) for cardiac resynchronization therapy (CRT). We sought to compare the acute hemodynamic and ECG effects of LBBAP, BVP, and left bundle-optimized therapy CRT (LOT-CRT) in CRT candidates with advanced conduction disease. METHODS: In this multicenter study, 48 patients with either nonspecific interventricular conduction delay (n=29) or left bundle branch block (n=19) underwent acute hemodynamic testing to determine the change in left ventricular pressure maximal first derivative (LV dP/dtmax) from baseline atrial pacing to BVP, LBBAP, or LOT-CRT. RESULTS: Atrioventricular-optimized increases in LV dP/dtmax for LOT-CRT (mean, 25.8% [95% CI, 20.9%–30.7%]) and BVP (26.4% [95% CI, 20.2%–32.6%]) were greater than unipolar LBBAP (19.3% [95% CI, 15.0%–23.7%]) or bipolar LBBAP (16.4% [95% CI, 12.7%–20.0%]; P≤0.005). QRS shortening was greater in LOT-CRT (29.5 [95% CI, 23.4–35.6] ms) than unipola
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CRT patients with complex conduction disease, ischemic cardiomyopathy, wide baseline QRS and suboptimal LBBAP (deep septal pacing) are more likely to benefit from LOT-CRT #AHAJournals #Epeeps @Marek_Jastrz_E @zacharywhinnett @rdschaller @ep_travis https://t.co/PfEtY4lZoc https://t.co/XfIe1gh4Um
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Mashup Score: 60Atrial Topology for a Unified Understanding of Typical and Atypical Flutter | Circulation: Arrhythmia and Electrophysiology - 14 day(s) ago
BACKGROUND: Macroreentry stands as the predominant mechanism of typical and atypical flutter. Despite advances in mapping, many aspects of macroreentrant atrial tachycardia remain unsolved. In this translational study, we applied principles of topology to understand the activation patterns, entrainment characteristics, and ablation responses in a large clinical macroreentrant atrial tachycardia database. METHODS: Because the atrium can be topologically seen as a closed sphere with holes, we used a computational fixed spherical mesh model with a finite number of holes to induce and analyze macroreentrant atrial tachycardia. The ensuing insights were used to interpret high-density activation maps, postpacing interval-tachycardia cycle length values (difference between postpacing interval and tachycardia cycle length), and ablation response in 131 cases of typical and atypical flutter (n=106 left atrium, n=25 right atrium). RESULTS: Modeling of macroreentrant atrial tachycardia revealed t
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Exploring macro-reentrant atrial tachycardia through topology reveals critical boundaries, enhancing understanding and management of typical and atypical flutter @nvandersickel #AHAJournals #Epeeps https://t.co/vibNaOjKmT https://t.co/bFT1U3cWAs
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Mashup Score: 5
BACKGROUND: Atrial fibrillation is associated with an increased risk of cardiovascular hospitalization (CVH), which may be triggered by changes in daily burden. Machine learning of dynamic trends in atrial fibrillation burden, as measured by insertable cardiac monitors (ICMs), may be useful in predicting near-term CVH. METHODS: Using Optum’s deidentified Clinformatics Data Mart Database (2007–2019), linked with the Medtronic CareLink ICM database, we identified patients with >1 days of ICM-detected atrial fibrillation. ICM-detected diagnostic parameters were transformed into simple moving averages over different periods for daily follow-up. A diagnostic trend was defined as the comparison of 2 simple moving averages of different periods for each diagnostic parameter. CVH was defined as any hospital, emergency department, or ambulatory surgical center encounter with a cardiovascular diagnosis-related group or diagnosis code. Machine learning was used to determine which diagnostic trends
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ML techniques applied to insertable cardiac monitor data allows for prediction of CV hospitalization in known AF patients and can help guide AF care #AHAJournals #Epeeps @jonpiccinisr @AndreaRussoEP @drsuneet https://t.co/Qr02adbM55 https://t.co/2lpVocOwZT
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Mashup Score: 48Performance of Atrial Fibrillation Burden Trends for Stroke Risk Stratification | Circulation: Arrhythmia and Electrophysiology - 28 day(s) ago
BACKGROUND: Atrial fibrillation (AF) is associated with an increased risk of stroke, yet the limitations of conventional monitoring have restricted our understanding of AF burden risk thresholds. Predictive algorithms incorporating continuous AF burden measures may be useful for predicting stroke. This study evaluated the performance of temporal AF burden trends as predictors of stroke from a large cohort with insertable cardiac monitors. METHODS: Using deidentified data from Optum Clinformatics Data Mart (2007–2019) linked with the Medtronic CareLink insertable cardiac monitor database, we identified patients with an insertable cardiac monitor for AF management (n=1197), suspected AF (n=1611), and cryptogenic stroke (n=2205). Daily AF burden was transformed into simple moving averages, and temporal AF burden trends were defined as the comparison of unique simple moving average pairs. Classification trees were used to predict ischemic stroke, and AF burden significance was quantified u
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#AFIB burden trends may be a better predictor of stroke than daily arrhythmia burden thresholds #AHAJournals #Epeeps @AndreaRussoEP @drsuneet @jonpiccinisr https://t.co/xpAjahkx0w https://t.co/JtWPNkfl9Q
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Mashup Score: 19
View all available purchase options and get full access to this article. Request permissions for this article. Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Brazil. Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Brazil. Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Brazil. Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina, Universidade
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
Exercising to enhance cognitive function may improve patient self-care and treatment adherence, reducing hospitalization and mortality rates in HFAF #AHAJournals #Epeeps @Bocchi https://t.co/Q8DWQ9003p https://t.co/XNFlwAbRtd
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Mashup Score: 27Resuscitated Sudden Cardiac Arrest as the Initial Presentation of Hypertrophic Cardiomyopathy | Circulation: Arrhythmia and Electrophysiology - 1 month(s) ago
View all available purchase options and get full access to this article. Request permissions for this article. Department of Internal Medicine, Mayo Clinic, Rochester, MN. (W.H.S.) Departments of Pediatric and Adolescent Medicine (Division of Pediatric Cardiology) and Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, MN. (M.J.A.) For Sources of Fun ding and Disclosures, see page XXX. Correspondence to: Konstantinos C.
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Cardiac arrest may be the initial HCM manifestation. These patients remain at risk for recurrent VT/VF but have good long-term survival with contemporary management #AHAJournals #Epeeps https://t.co/EcbvdVZg84 https://t.co/iw2w8NeTC5
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Mashup Score: 5
BACKGROUND: Currently, there are no reliable methods for predicting and preventing atrial fibrillation (AF) in its early stages. This study aimed to identify plasma proteins associated with AF to discover biomarkers and potential drug targets. METHODS: The UK Biobank Pharma Proteomics Project examined 2923 circulating proteins using the Olink platform, forming the basis of this prospective cohort study. The UK Biobank Pharma Proteomics Project included a randomly selected discovery cohort and the consortium-selected replication cohort. The study’s end point was incident AF, identified using International Classification of Diseases, Tenth Revision codes. The association between plasma proteins and incident AF was evaluated using Cox proportional hazard models in both cohorts. Proteins present in both cohorts underwent Mendelian randomization analysis to delineate causal connections, utilizing cis-protein quantitative trait loci as genetic tools. The predictive efficacy of the identified
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Identified 21 proteins linked to new-onset AF via proteomics. MR analysis confirms COL4A1 and RET as causal; COL4A1 boosts AF prediction models, and RET shows drug target potential #AHAJournals #Epeeps https://t.co/uxOk20LV5F https://t.co/unipXMgVoB
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Mashup Score: 40Focal Pulsed Field Ablation for Premature Ventricular Contractions: A Multicenter Experience | Circulation: Arrhythmia and Electrophysiology - 1 month(s) ago
BACKGROUND: Pulsed field ablation (PFA) is a novel technology for catheter-based atrial arrhythmia treatment. Evidence of its application for ventricular arrhythmia ablation is still limited. In this study, we describe the feasibility and efficacy of focal PFA for premature ventricular contraction (PVC) ablation. METHODS: A prospective cohort of 20 patients referred for PVC ablation at 2 centers was enrolled, regardless of the presence of structural heart disease, PVC morphology, or previous ablation attempts. All procedures were performed using the CENTAURI System in combination with contact force sensing catheters and 3-dimensional electroanatomical mapping systems. Energy output and the number of applications were left to the operator’s discretion. RESULTS: Eleven (55%) procedures were conducted under general anesthesia, 6 (30%) under deep sedation, and 3 (15%) under light sedation. Muscular contraction was observed in one case (5%). Median procedural and fluoroscopy times were 95.5
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In this multicentric prospective study, focal PFA was effective and safe for PVC invasive treatment, leading to 85% acute and long-term success rate @cespon_maria @AlviseDelMonte @dogi84md #AHAJournals #Epeeps https://t.co/ZkLdfulqnM https://t.co/ynqEtXc2sz
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Impact of Being Underweight on the Safety and Efficacy of Atrial Fibrillation Ablation: An Analysis From the Japanese Catheter Ablation Registry @ReinaTonegawa #AHAJournals #Epeeps https://t.co/uzCBLTLT8f