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Mashup Score: 5
BACKGROUND: In aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. Following aortic valve replacement (AVR), left ventricular hypertrophy regression occurs, but early cellular and extracellular dynamics are unknown. METHODS: Patients with severe symptomatic aortic stenosis undergoing surgical or transcatheter AVR were prospectively recruited. Pre- and early post-AVR cardiac magnetic resonance imaging assessed left ventricular remodeling, global longitudinal strain, and T1 mapping to determine extracellular volume fraction and volume of cellular and extracellular compartments. RESULTS: In all, 39 patients (aged 71.4±9.8 years, male 79%, aortic valve peak velocity 4.4±0.5 m/s) underwent cardiac magnetic resonance before and at median 7.7 weeks post-AVR. Left ventricular mass index reduced significantly by 15.4% (P<0.001*), primarily driven by c
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Mashup Score: 12Boys With Duchenne Muscular Dystrophy Have Diastolic Dysfunction Based on CMR | Circulation: Cardiovascular Imaging - 13 hour(s) ago
BACKGROUND: Cardiomyopathy is the leading cause of death in boys with Duchenne muscular dystrophy (DMD). While cardiac magnetic resonance (CMR) is routinely used to assess fibrosis and left ventricular (LV) ejection fraction, CMR measures of LV filling and ejection in DMD have not been reported. METHODS: Patients with DMD (n=179) and healthy controls (n=96) were prospectively enrolled and underwent CMR. The DMD cohort was followed clinically at multiple institutions, and clinical data were recorded. Standard volumes and functions were calculated, and LV filling and ejection curves were measured from baseline CMR. Multivariable linear regressions were used to compare ventricular filling and ejection measures between groups, adjusting for baseline differences. Cox regressions were used to evaluate the relationship between diastolic function measures and mortality in the DMD cohort. RESULTS: Patients with DMD had significantly smaller stature and ventricular volumes than healthy control p
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Boys with Duchenne have systolic and diastolic dysfunction on CMR, evidenced by slower peak ventricular filling rates (PFR) (p<0.001) and peak ventricular ejection rates (PER) (p<0.001), and they are independently associated with mortality #AHAJournals https://t.co/lIKBrGH0R6 https://t.co/DIEcSDAN5O
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Mashup Score: 6Rare Presentation and Treatment Strategy of Acute Myocardial Infarction in a Young Patient | Circulation: Cardiovascular Imaging - 2 day(s) ago
View all available purchas e options and get full access to this article. Request permissions for this article. Houston Methodist DeBakey Heart and Vascular Institute, TX. Houston Methodist DeBakey Heart and Vascular Institute, TX. Houston Methodist DeBakey Heart and Vascular Institute, TX. For Sources of Funding and Disclosures, see page XXX. Correspondence to: El-Moatasem Gabr, MD, Houston Methodist DeBakey Heart and Vascular Institute, 8181 Fannin St, Apt 2423, Houston, TX 77054. Email [email protected]
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Mashup Score: 7Hepatic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications | Circulation: Cardiovascular Imaging - 17 day(s) ago
BACKGROUND: The presence and clinical significance of hepatic tissue alterations as assessed by cardiac magnetic resonance imaging in patients with ST-segment–elevation myocardial infarction (STEMI), are unclear. This study aimed to investigate associations of hepatic T1 patterns with myocardial tissue damage and clinical outcomes in patients suffering from STEMI. METHODS: We analyzed 485 patients with STEMI treated with percutaneous coronary intervention who were enrolled in the prospective magnetic resonance imaging in acute ST-elevation myocardial infarction study (MARINA STEMI). Myocardial function and left and right ventricular (RV) infarct characteristics were assessed by cardiac magnetic resonance within the first week after STEMI. Native hepatic T1 times and extracellular volume were evaluated from standard cardiac T1 maps at baseline and 4 months thereafter. RESULTS: Median hepatic T1 times were 559 ms (interquartile range, 514–605) at baseline and decreased to 542 ms (interqu
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Mashup Score: 1
BACKGROUND: Black adults show heightened cardiovascular risk compared with other groups despite comparable or lower coronary artery calcium (CAC) scores, indicating potential cardiovascular risk underestimation by CAC. Abdominal aortic calcification (AAC), preceding CAC, may predict cardiovascular events better in Black adults who are prone to early atherosclerotic cardiovascular disease and excess events at low CAC scores. METHODS: We included 2551 participants from the JHS (Jackson Heart Study) visit 2 examination (2005–2008) without cardiovascular disease, followed through 2016. Cox regression estimated hazard ratios for incident cardiovascular events defined as a composite of myocardial infarction, stroke, heart failure, and all-cause mortality. The predictive value of CAC and AAC, when added to the American College of Cardiology/American Heart Association cardiovascular risk algorithm (pool cohort equation), was assessed. RESULTS: Mean age was 57±10 years; 66% were women. Over a f
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Mashup Score: 18Eclipsed Mitral Regurgitation as an Early Sign of Myocardial Ischemia Due to Coronary Vasospasm | Circulation: Cardiovascular Imaging - 18 day(s) ago
View all available purchase options and get full access to this article. File (circcvim-2024-017521-s04.pdf) Videos S1–S3 File (circcvim-2024-017521-s01.mov) File (circcvim-2024-017521-s02.mov) File (circcvim-2024-017521-s03.mov) Request permissions for this article. For Sources of Funding and Disclosures, see page XXX. Correspondence to: Ana Garcia-Martin, MD, PhD, University Hospital Ramón y Cajal, M-607, Km 9, 100, Fuencarral-El Pardo, 28034 Madrid, Spain. Email [email protected] If you have the
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Mashup Score: 20
BACKGROUND: Coronary artery calcium (CAC) is heterogeneous in older age and is incompletely explained by traditional atherosclerotic cardiovascular disease risk factors. The extremes of subclinical atherosclerosis burden are strongly associated with either a low or high 10-year risk of incident atherosclerotic cardiovascular disease, respectively. However, the genetic underpinnings of differences in arterial aging remain unclear. We sought to determine the independent association of 2 polygenic scores for coronary heart disease (CHD) with CAC in adults ≥75 years of age. METHODS: There were 1865 ARIC (Atherosclerosis Risk in Communities) participants who underwent genetic testing at visit 1 (1987–1989) and CAC scans at visit 7 (2018–2019). In the primary analysis, an externally derived multi-ancestry polygenic CHD risk score was calculated for both White and Black participants. Results were confirmed using a separate ARIC-derived polygenic CHD risk score, including ≥6 million variants c
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Mashup Score: 0CME for Physicians | AHA/ASA Journals - 1 month(s) ago
Not yet an AHA member? The AHA has several membership categories. Join now. You’re reading the articles. Now earn the credit. New CME quizzes posted weekly Earn up to 74 credits annually Improved, 1-click article-to-quiz access from the online table of contents How It Works Join or renew your AHA membership at professional.heart.org. Access to the AHA Journals CME program is included. Read designated journal articles from Circulation, Circulation: Cardiovascular Imaging, and Stroke. Articles are easily
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Mashup Score: 0CME for Physicians | AHA/ASA Journals - 1 month(s) ago
Not yet an AHA member? The AHA has several membership categories. Join now. You’re reading the articles. Now earn the credit. New CME quizzes posted weekly Earn up to 74 credits annually Improved, 1-click article-to-quiz access from the online table of contents How It Works Join or renew your AHA membership at professional.heart.org. Access to the AHA Journals CME program is included. Read designated journal articles from Circulation, Circulation: Cardiovascular Imaging, and Stroke. Articles are easily
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Mashup Score: 0CME for Physicians | AHA/ASA Journals - 1 month(s) ago
Not yet an AHA member? The AHA has several membership categories. Join now. You’re reading the articles. Now earn the credit. New CME quizzes posted weekly Earn up to 74 credits annually Improved, 1-click article-to-quiz access from the online table of contents How It Works Join or renew your AHA membership at professional.heart.org. Access to the AHA Journals CME program is included. Read designated journal articles from Circulation, Circulation: Cardiovascular Imaging, and Stroke. Articles are easily
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet
Do you know the reduction of LV mass after AVR will be driven by "cellular compartment regression" or "extracellular regression"? Check out the new article in @CircImaging below! #AHAJournals @JiwonKimMD @kaznegishi https://t.co/hBvZUjkX1k https://t.co/UOLNKigtFp