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Mashup Score: 3
Internistische Intensivstation KMT-III Auf unserer internistischen Intensivtherapiestation werden Patientinnen und Patienten behandelt, bei denen lebenswichtige Funktionen des Körpers gestört sind. Hierzu gehören u. a. schwerwiegende Infektionen mit Sepsis, akute Lungenerkrankungen bis hin zum Lungenversagen, Störungen der Blutbildung oder Gerinnungsfunktion des Bluts. Neben schwerpunktmäßig internistischen Notfällen und Intensivpatienten aus dem gesamten Gebiet der Inneren Medizin besitzt […]
Source: www.uni-essen-haematologie.deCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 29Evolutionary trajectories of small cell lung cancer under therapy - 1 month(s) ago
Nature – We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central…
Source: www.nature.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 13An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL - 2 month(s) ago
Chimeric antigen receptor T cell (CAR T) therapy is a potent treatment for relapsed/refractory (r/r) B cell lymphomas but provides lasting remissions …
Source: www.sciencedirect.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 7
The Cambridge Lymphoma International Symposium will bring together biological and clinical lymphoma scientists working on lymphoma and CLL. Topics will include functional genomics, biology of the germinal centre, haematopoietic stem cells, RNA biology, role of the microenvironment and novel therapeutics.
Source: www.haem.cam.ac.ukCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 3Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA - 3 month(s) ago
Tumor-agnostic ctDNA sequencing in CNSL is feasible and allows for detection of PRD.We propose the molecular prognostic index for CNSL, a model integrating clin
Source: ashpublications.orgCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 50West German Lymphoma Symposium - 3 month(s) ago
Dear Colleagues and Guests The field of preclinical and clinical lymphoma research has seen a dramatic acceleration of progress during the last years, ranging from a molecular characterization of the disease to the development of novel mouse models, as well as preclinical drug development, ultimately cumulating in massive alterations of our current treatment algorithms, now […]
Source: www.lymphoma-symposium.deCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 4
Blood cancers are still challenging to treat, despite diverse therapeutic options. Cancer underlies evolutionary principles with single cells and clones being selectable entities. They evolve over ti…
Source: meetings.embo.orgCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 31An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma - 5 month(s) ago
Key Points. In mouse models of Myd88-driven DLBCL, the presence of a Cd79b ITAM mutation results in increased BCR proximal signaling.The increased BCR signaling
Source: ashpublications.orgCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 1Mouse models of diffuse large B cell lymphoma - 5 month(s) ago
Diffuse large B cell lymphoma (DLBCL) is a genetically highly heterogeneous disease. Yet, to date, the vast majority of patients receive standardized frontline chemo-immune-therapy consisting of an anthracycline backbone. Using these regimens, approximately 65% of patients can be cured, whereas the remaining 35% of patients will face relapsed or refractory disease, which, even in the era of CAR-T cells, is difficult to treat. To systematically tackle this high medical need, it is important to design, generate and deploy suitable in vivo model systems that capture disease biology, heterogeneity and drug response. Recently published, large comprehensive genomic characterization studies, which defined molecular sub-groups of DLBCL, provide an ideal framework for the generation of autochthonous mouse models, as well as an ideal benchmark for cell line-derived or patient-derived mouse models of DLBCL. Here we discuss the current state of the art in the field of mouse modelling of human DLBC
Source: www.frontiersin.orgCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 13Job Finder - Karriereportal - Universitätsklinikum Essen - 5 month(s) ago
Finden Sie eine Stelle am Universitätsklinikum Essen
Source: karriere.ume.deCategories: General Medicine News, Hematologists1Tweet
RT @HamatologieUk: Pls RT: Unsere internistische Intensivstation https://t.co/iKnqBmnKBu @HamatologieUk wächst und dafür suchen wir begeis…