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Mashup Score: 0
Blue et al. characterize the genetic basis of isolated hypoplastic left heart syndrome (iHLHS), implicating hypomorphic CAPN2 variants through association testing and functional validation in a Xenopus laevis model. Their results suggest that iHLHS is not typically a Mendelian condition and identify a novel pathway involved in HLHS pathogenesis.
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Mashup Score: 5Genome-scale CRISPR screening in a single mouse liver - 6 hour(s) ago
Improved understanding of physiology and disease requires methods for high-throughput genetic dissection in the organism. Here, Keys and Knouse establish genome-scale screening in the mouse liver and apply this to uncover regulation of hepatocyte fitness. This approach offers an accessible and adaptable platform for high-throughput functional genomics in the organism.
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Mashup Score: 4spotlight-inspirational-women-in-biophysics: Biophysical Journal - 9 hour(s) ago
Interviews with five inspirational women in biophysics and published authors in Biophysical Society journals, Biophysical Journal and Biophysical Reports, who describe their career journeys, roadblocks, and motivations and share tips for success, thoughts on gender equity in science, and insights for women scientists. Scripps Research Institute, California University of Virginia School of Medicine, USA Arizona State University and The Biodesign Institute, USA Please could you give us a brief introduction
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Mashup Score: 1Cell Press | Cell Genomics - 11 hour(s) ago
Cell Genomics provides an accessible forum for authors and is an indispensable resource for geneticists in all disciplines. In the run-up to receiving our first Impact Factor in June 2024, we focus in on two rising topics — CRISPR and Neurogenomics — and are pleased to share corresponding papers published in Cell Genomics. Learn more Applying the technology utilizing clustered regularly interspaced short palindromic repeats, or more colloquially CRISPR, to edit genome sequences allows for in depth studies
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Mashup Score: 2
Cell Symposia: Engineering development and disease in organoids
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Mashup Score: 41Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development - 1 day(s) ago
Lau and colleagues generated an in vitro mouse embryo model with embryonic and extraembryonic lineages using exclusively embryonic stem cells and showed that the embryoids can undergo advanced development to late headfold stages. Single-cell RNA sequencing demonstrates similarity between embryoids and natural mouse embryos.
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Mashup Score: 76Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15 - 1 day(s) ago
Devarajan et al. identify signals provided by infection that synergize to drive CD4 effectors to develop into lung cytotoxic CD4 cells (ThCTLs) that kill influenza-virus-infected cells. They include recognition of Ag on APCs in the lung and infection-elicited type I IFN that acts by inducing IL-15 to support ThCTL generation.
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Mashup Score: 2Immunology collection: Cell Press - 1 day(s) ago
A Cell Press collection on immunology showcasing leading research and reviews from across our portfolio.
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Mashup Score: 4A multi-omics systems vaccinology resource to develop and test computational models of immunity - 1 day(s) ago
Shinde et al. establish a community resource to compare patients’ vaccine responses and to host annual contests to predict vaccination outcomes. They find specifically trained multi-omics models and simple age-based models outperformed. They aim to engage the community with a public prediction contest starting August 2024.
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Mashup Score: 105
Cancer immunity is subject to spatiotemporal regulation by leukocyte interaction with the tumor microenvironment. Growing evidence suggests an emerging role for the vasculature in tumor immune evasion and immunotherapy resistance. Beyond the conventional functions of the tumor vasculature, such as providing oxygen and nutrients to support tumor progression, we propose multiplex mechanisms for vascular regulation of tumor immunity: The immunosuppressive vascular niche locoregionally educates circulation-derived immune cells by angiocrines, aberrant endothelial metabolism induces T cell exclusion and inactivation, and topologically and biochemically abnormal vascularity forms a pathophysiological barrier that hampers lymphocyte infiltration. We postulate that genetic and metabolic reprogramming of endothelial cells may rewire the immunosuppressive vascular microenvironment to overcome immunotherapy resistance, serving as a next-generation vascular targeting strategy for cancer treatment.
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Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome https://t.co/VE5YNwveXb @HGGAdvances paper hand-picked by our editors @BrotmanBaty @GeneticsSociety