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Mashup Score: 0Gene Therapy for Human Genetic Disease? - 3 day(s) ago
In our view, gene therapy may ameliorate some human genetic diseases in the future. For this reason, we believe that research directed at the development of techniques for gene therapy should continue. For the foreseeable future, however, we …
Source: www.science.orgCategories: General Medicine NewsTweet
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Mashup Score: 7UCSD Biosensor Core - 8 day(s) ago
Web site created using create-react-app
Source: ucsd-biosensor-core.vercel.appCategories: General Medicine NewsTweet-
RT @NathanShaner: UCSD Biosensor Core (https://t.co/y0cPSij2pq) is hiring a Research Associate: cell culture, lab maintenance, opportunitie…
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Mashup Score: 2
Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mutation or small molecules may alter contractility through myofilament Ca2+ sensitivity. Here, we develop and characterize genetically encoded Ca2+ indicators restricted to the myofilament to directly visualize Ca2+ changes in the sarcomere. Objective: To produce and validate myofilament-restricted Ca2+ imaging probes in an adenoviral transduction adult cardiomyocyte model using drugs that alter myofilament function (MYK-461, omecamtiv mecarbil, and levosimendan) or following cotransduction of 2 established hypertrophic cardiomyopathy disease-causing mutants (cTnT [Troponin T] R92Q and cTnI [Troponin I] R145G) that alter myofilament Ca2+ handling. Methods and Results: When expressed in adult ventricular cardiomyocytes RGECO-TnT (Troponin T)/TnI (Troponin I) sensors localize correctly to the sarcomere without contractile impairment. Both sensors report cyclical changes in fluorescence in p
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
@MasriAhmadMD That paper has an interesting story We thought @CircRes reviewers might ask us to combine two observations made in this piece https://t.co/DdykifTsLS That didn't happen, so we had a small story to write up separately Ironically the smaller paper is leading the citation count
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Mashup Score: 4
Thin filament hypertrophic cardiomyopathy (HCM) mutations increase myofilament Ca2+ sensitivity and alter Ca2+ handling and buffering. The myosin inhibitor mavacamten reverses the increased contractility caused by HCM thick filament mutations, and we here test its effect on HCM thin filament mutations where the mode of action is not known. Mavacamten (250 nM) partially reversed the increased Ca2+ sensitivity caused by HCM mutations Cardiac troponin T (cTnT) R92Q, and cardiac troponin I (cTnI) R145G in in vitro ATPase assays. The effect of mavacamten was also analyzed in cardiomyocyte models of cTnT R92Q and cTnI R145G containing cytoplasmic and myofilament specific Ca2+ sensors. While mavacamten rescued the hypercontracted basal sarcomere length, the reduced fractional shortening did not improve with mavacamten. Both mutations caused an increase in peak systolic Ca2+ detected at the myofilament, and this was completely rescued by 250 nM mavacamten. Systolic Ca2+ detected by the cytopla
Source: journals.physiology.orgCategories: General Medicine NewsTweet-
@MasriAhmadMD Look at the amplitude of contraction for the green line - as well as where it originates https://t.co/uayqSbxeQ0 https://t.co/9YWGN6Ujqv
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Mashup Score: 3
Introduction 2285 patients currently attend our regional inherited cardiac conditions (ICC) service, 652 of whom are screened or managed for hypertrophic cardiomyopathy (HCM). With the anticipated arrival of novel myosin ATPase inhibitors (1) for those with symptomatic left-ventricular outflow tract obstruction (LVOTO), we analysed our HCM cohort to identify patients who may be eligible for such therapies. Methods A database was populated with demographic, diagnostic, clinical and imaging data from electronic care records and imaging archives. Presence of significant LVOTO was defined as an outflow tract gradient ≥30 mmHg at rest or ≥50 mmHg on provocation as per European Heart Society guidelines (2). Symptomatic patients reported chest pain or New York Heart Association score ≥class II breathlessness. Results A guideline based clinical HCM phenotype was seen in 259 of the 652 patients; of which 63 (24.3%) had pathogenic sarcomeric variants and 26 (10%) had variants of unknown signific
Source: heart.bmj.comCategories: General Medicine NewsTweet-
@MasriAhmadMD I disagree with: "The findings of this trial help us understand that obstructive HCM & non-obstructive HCM are two unique diseases." We've seen non-obstructive patients develop LVOTO, & vice versa not infrequently - that quote is an oversimplification https://t.co/WY9LjCgYtP
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Mashup Score: 7Incident heart failure and recurrent coronary events following acute myocardial infarction - 12 day(s) ago
AbstractBackground and Aims. Recurrent myocardial infarction (MI) and incident heart failure (HF) are major post-MI complications. Herein, contemporary pos
Source: academic.oup.comCategories: General Medicine NewsTweet-
@cpgale3 @JavedButler1 has recently highlighted the problem of post infarct heart failure https://t.co/iCyhn6hETO There appears to be an unmet need here for STEMI and NSTEMI
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Mashup Score: 0Desert Island Discs - Marianne Faithfull - BBC Sounds - 3 month(s) ago
Sue Lawley’s castaway is musician and actress Marianne Faithfull
Source: www.bbc.co.ukCategories: General Medicine News, CardiologistsTweet-
@SVRaoMD https://t.co/99ua3wemHz Her choices for the sound track of her life - recorded 1995
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Mashup Score: 44
2025.01.23 大阪大学 プレスリリース 研究成果のポイント生物発光※1の波長 (色) を変化させる手法を新たに開発し、発光色のバリエーションがこれまでで最大の20色に拡大。カラーカメラを顕微鏡に設置することで、従来のモノクロカメラでは検出不可能だった、多数の発光色を示す細胞を同時に撮影するこ…
Source: research-er.jpCategories: General Medicine News, CardiologistsTweet-
RT @rjp_news: 【注目プレスリリース】２０色に光る細胞の同時観察を実現！ ―複数の細胞活動を追跡する新しい手法を確立 細胞個性の解析に期待― / 大阪大学 https://t.co/GW7EWYxt8D
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Mashup Score: 0Spam | Monty Python's Flying Circus series 2, episode 12 1970 - 6 month(s) ago
#spam #montypython #flyingcircus https://sunnysiders.org/supportus
Source: www.youtube.comCategories: General Medicine News, CardiologistsTweet-
@DBelardoMD What we really need AI to do for us is answer each of these calls and texts with an apt sketch from Monty Python Surely the business model will collapse if we collectively waste a few seconds of their time? https://t.co/rge4W7K6Ia https://t.co/gQZkePhqlD
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Mashup Score: 6Locum Associate or Senior Editor, Nature Reviews Methods Primers - 7 month(s) ago
Locum Associate or Senior Editor, Nature Reviews Methods Primers Fixed Term Contract (maternity leave cover) Location: London or New York (Hybrid Working) Closing date: 21st October 2024 About Springer Nature Group Springer Nature opens the doors to discovery for researchers, educators, clinicians and other professionals. Every day, around the globe, our imprints, books, journals, platforms and technology solutions reach millions of people. For over 180 years our brands and imprints have been a trusted source of knowledge to these communities and today, more than ever, we see it as our responsibility to ensure that fundamental knowledge can be found, verified, understood and used by our communities – enabling them to improve outcomes, make progress, and benefit the generations that follow. Visit http://group.springernature.com/ and follow @SpringerNature / @SpringerNatureGroup About The Brand Nature Portfolio is a flagship portfolio of journals, products and services including Nature a
Categories: General Medicine News, CardiologistsTweet-
RT @rita_strack: Nature Reviews Methods Primers is hiring a locum editor! https://t.co/N2HsVWPhIm
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@DrJMarine @NIH Now we are starting to see some of the promised bench to bedside translation (about 10 approved therapies), but for an idea that kicked off in the 1970s https://t.co/AFUi6jnVAl how many rounds of funding have been futile, or at best only informative for what doesn't work? 4/