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Mashup Score: 22Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis - 5 hour(s) ago
Gupta et al. track checkpoint inhibitor (CPI)-bound T cells utilizing scRNA-seq and subcellular spatial transcriptomics in blood and intestinal tissue, defining distinct T cell subtypes and tissue niches linked to colitis development. They define the pathogenic cellular microdomains differentiating CPI-colitis from ulcerative colitis (UC).
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Mashup Score: 283The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia - 14 hour(s) ago
Liu et al. identify a novel feedforward loop between tumor cells and macrophages that promotes muscle wasting. Specifically, tumor-derived CCL2 activates macrophages to facilitate non-autonomous activation of TWEAK in tumor cells via CCL5/p65 signaling, leading to cachexia. Macrophage depletion and TWEAK inhibition represent promising therapeutic targets for pancreatic cancer cachexia.
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Mashup Score: 283The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia - 19 hour(s) ago
Liu et al. identify a novel feedforward loop between tumor cells and macrophages that promotes muscle wasting. Specifically, tumor-derived CCL2 activates macrophages to facilitate non-autonomous activation of TWEAK in tumor cells via CCL5/p65 signaling, leading to cachexia. Macrophage depletion and TWEAK inhibition represent promising therapeutic targets for pancreatic cancer cachexia.
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Mashup Score: 59Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas - 1 day(s) ago
For more than 70 years, glucocorticoids have been known to have clinical activity against lymphoid but not myeloma malignancies. Choi et al. resolve this conundrum by demonstrating that glucocorticoids kill lymphomas by inhibiting BCR signaling. These mechanistic insights enable rational combination of glucocorticoids with other targeted agents in anti-lymphoma regimens.
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Mashup Score: 134
The molecular response of IDH-mutant glioma to mutant IDH inhibitors is poorly understood. Spitzer et al. show that, in patients with clinical response, mutant IDH inhibitors induce lineage differentiation of cancer cells and deplete cells in a stem/progenitor-like state. They further highlight potential modifiers of such differentiation response in glioma.
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Mashup Score: 143Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy - 2 day(s) ago
Attempts to improve dual anti-PD-1+CTLA-4 ICB efficacy by including additional therapeutics have been largely discouraged due to concerns of further increasing toxicity. Xue et al. identify that the antibiotic clofazimine potentiates the antitumor effects of anti-PD-1+CTLA-4 immunotherapy and mitigates immune-related adverse effects in mice.
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Mashup Score: 218
Niu et al. identify a lipid-laden CAF subset marked by ABCA8a in Setd2-deficient pancreatic tumors, which transports lipids and metabolically sustains tumor growth via OXPHOS. Both in vivo and ex vivo experiments reveal that tumor-intrinsic SETD2 loss induces epigenetic reprogramming and unleashes BMP signaling to foster the differentiation of lipid-laden CAFs.
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Mashup Score: 19Home – Hallmarks of Cancer - 2 day(s) ago
Hallmarks of Cancer
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Mashup Score: 156
Cancer-associated fibroblasts (CAFs) exhibit spatial and functional diversity. Here, Niu et al. unveil SETD2’s function in lipid metabolism and CAF heterogeneity in pancreatic ductal adenocarcinoma. SETD2 deficiency boosts oxidative phosphorylation activity, prompting lipid-laden CAF formation through BMP2 signaling, offering promising therapeutic avenues in personalized cancer treatment.
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Mashup Score: 212
Tumor-associated macrophages (TAMs) are well known to fuel tumor evolution. Blériot et al. advocate for integrating the time dimension when conceptualizing macrophage diversity in pre-malignancy and cancer and propose the term “PreTAMs” to emphasize their early roles in orchestrating inflammatory responses that often precede, and not just result from, tumor onset.
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Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis https://t.co/F7w0pVFCma https://t.co/VZzsZYFzzI