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Mashup Score: 6Connecting the dots from let-7 to HIC2 to HBG - 4 hour(s) ago
In this issue of Blood, Huang et al1 show that HIC2 messenger RNA (mRNA) is a direct target of let-7 microRNA (miRNA), providing a crucial link between LIN
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Mashup Score: 15Patrolling progenitors: a first responder team - 6 hour(s) ago
In this issue of Blood, Quaranta et al identify human circulating hematopoietic stem and progenitor cells (cHSPCs) that help maintain steady-state hematopo
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Mashup Score: 21Circulating hematopoietic stem/progenitor cell subsets contribute to human hematopoietic homeostasis - 24 hour(s) ago
Circulating multilymphoid progenitors are primed for the seeding the thymus and contribute to steady-state T-cell lymphopoiesis.cHSPCs are responsible for
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Mashup Score: 19PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway - 1 day(s) ago
PI3Kγ functions as a critical enzyme in acute myeloid leukemia development but not in normal hematopoiesis.Targeting PI3Kγ represents a promising therapy t
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Mashup Score: 32Castleman disease with modest T-lymphoblastic proliferation - 1 day(s) ago
A 7-month-old boy with a history of biliary atresia presented with abdominal distension. Laboratory data showed anemia, thrombocytopenia, hypoalbuminemia, hypergammaglobulinemia, and elevated interleukin-6 and erythrocyte sedimentation rate. Imaging showed extensive abdominal and retroperitoneal lymphadenopathy. Lymph node biopsy demonstrated features of Castleman disease, mixed variant (panel A-B, hematoxylin and eosin [H & E] stain, 4× objective, 20× objective, respectively). Interfollicular areas
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Mashup Score: 37PIKing the right target in AML - 1 day(s) ago
In this issue of Blood, Gu et al dissect the different role of phosphotidylinositol 3-kinase (PI3K) isoforms in acute myeloid leukemia (AML) and identify a
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Mashup Score: 159Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel - 2 day(s) ago
In a pair of Special Reports, Gökbuget and colleagues present updated European Leukemia Net (ELN) consensus reports on (1) the diagnosis, prognostic factor
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Mashup Score: 7Taking AIM - 2 day(s) ago
In this issue of Blood, Arce and colleagues present an elegant study showing that the autoinhibitory module (AIM) of von Willebrand factor (VWF) may be tar
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Mashup Score: 36PIKing the right target in AML - 2 day(s) ago
In this issue of Blood, Gu et al dissect the different role of phosphotidylinositol 3-kinase (PI3K) isoforms in acute myeloid leukemia (AML) and identify a
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Mashup Score: 40SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma - 5 day(s) ago
SOX11 directly binds, via its HMG domain, to SAMHD1, reducing its tetramerization and inhibiting its ara-CTPase activity in MCL.The noncompetitive inhibito
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Connecting the dots from let-7 to HIC2 to HBG https://t.co/TVEEjjHgcN #redcellsironanderythropoiesis https://t.co/knU5y8wZ49