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Mashup Score: 203Final U.S. spending bills offer gloomy outlook for science - 2 month(s) ago
Key research funding agencies get sizable cuts or flat budgets
Source: www.science.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 203Final U.S. spending bills offer gloomy outlook for science - 2 month(s) ago
Key research funding agencies get sizable cuts or flat budgets
Source: www.science.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 74
A study in Science uses bacteria from the Long-Term Evolution Experiment to report on how fitness effects of mutations change through evolution.
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 92Exploring gene content with pangenome gene graphs - 3 month(s) ago
Motivation: The gene content regulates the biology of an organism. It varies between species and between individuals of the same species. Although tools have been developed to identify gene…
Source: arXiv.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 3SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells - 3 month(s) ago
SLC25A51 selectively imports oxidized NAD+ into the mitochondrial matrix and is required for sustaining cell respiration. We observed elevated express…
Source: www.sciencedirect.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 16Massively parallel single-cell sequencing of diverse microbial populations - Nature Methods - 3 month(s) ago
DoTA-seq leverages a microfluidic droplet system to isolate and lyse diverse microbes and amplify target genetic loci, enabling high-throughput single-cell sequencing of microbial populations.
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 20
Epigenomic, biochemical, structural, and human phenotypic analyses of transcription factors that regulate a composite DNA motif in the embryonic face and limb mesenchyme reveal how DNA-guided cooperative binding gives rise to specificity among members of large TF families. This cooperativity promotes the integration of cellular and positional identity programs and contributes to the evolution and individual variation of human facial shape.
Source: www.cell.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 20
Epigenomic, biochemical, structural, and human phenotypic analyses of transcription factors that regulate a composite DNA motif in the embryonic face and limb mesenchyme reveal how DNA-guided cooperative binding gives rise to specificity among members of large TF families. This cooperativity promotes the integration of cellular and positional identity programs and contributes to the evolution and individual variation of human facial shape.
Source: www.cell.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 8
Genomic rearrangements, encompassing mutational changes in the genome such as insertions, deletions, or inversions, are essential for genetic diversity. These rearrangements are typically orchestrated by enzymes involved in fundamental DNA repair processes such as homologous recombination or in the transposition of foreign genetic material by viruses and mobile genetic elements (MGEs). We report that IS110 insertion sequences, a family of minimal and autonomous MGEs, express a structured non-coding RNA that binds specifically to their encoded recombinase. This bridge RNA contains two internal loops encoding nucleotide stretches that base-pair with the target DNA and donor DNA, which is the IS110 element itself. We demonstrate that the target-binding and donor-binding loops can be independently reprogrammed to direct sequence-specific recombination between two DNA molecules. This modularity enables DNA insertion into genomic target sites as well as programmable DNA excision and inversio
Source: www.biorxiv.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 5
Michael Lauer, head of NIH’s Office of Extramural Research, and two colleagues published National Institutes of Health research project grant inflation 1998 to 2021 in eLife in 2021. Per the …
Source: drugmonkey.scientopia.orgCategories: General Medicine News, Infectious DiseaseTweet
Scientific research has been the engine of American economic growth for over half a century. From lifesaving medicines to the device you are reading this on. With these bills, congress takes one more step towards ceding that leadership abroad. https://t.co/8IaL1xAQUW