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Mashup Score: 0Gazing into the Proteomic Crystal Ball: Predicting Survival in Idiopathic Pulmonary Fibrosis - 1 hour(s) ago
In many respects, idiopathic pulmonary fibrosis (IPF) is a predictable disease. It is a condition characterized by inevitable and usually inexorable progression with an untreated median survival of between 3 and 5 years (1). However, a look beyond population-level statistics and examination of the disease behavior of individual patients reveals considerable heterogeneity. Some individuals have rapidly progressive disease and die within months of diagnosis, whereas others have relatively indolent disease,
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 14Commensal Oral Microbiota, Disease Severity, and Mortality in Fibrotic Lung Disease - 16 hour(s) ago
Rationale: Oral microbiota associate with diseases of the mouth and serve as a source of lung microbiota. However, the role of oral microbiota in lung disease is unknown. Objectives: To determine a…
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Mashup Score: 1
Rationale: Computed tomography (CT) enables noninvasive diagnosis of usual interstitial pneumonia (UIP), but enhanced image analyses are needed to overcome the limitations of visual assessment. Obj…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 10
Few observations in the field of the airway microbiome have been as consistently replicated as the one in which high bacterial burden in the lower airways is associated with poor prognosis in idiopathic pulmonary fibrosis (IPF) (1 – 4). The excitement around that observation led the NIH to support a clinical trial using antibiotics as a potential approach to this condition. The hope was so great that even the name of the trial was optimistic: CleanUP-IPF. It was a multicenter, randomized placebo-controlled
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 15
Rationale: Idiopathic pulmonary fibrosis (IPF) causes progressive lung scarring and high mortality. Reliable and accurate prognostic biomarkers are urgently needed. Objectives: To identify and vali…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 6
Since the successful pivotal studies of pirfenidone (1) and nintedanib (2) for idiopathic pulmonary fibrosis (IPF), several drugs have shown promise in early-phase clinical trials (3, 4) only to fail on efficacy grounds in registrational studies (5). With antifibrotic therapy representing standard of care, successful trials rely on demonstrating further attenuation in FVC decline. Enrolling patients who remain stable over the course of a clinical trial represents a risk, as progression is necessary to be
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 6Ambient Ultrafine Particulate Matter and Clinical Outcomes in Fibrotic Interstitial Lung Disease - 2 day(s) ago
Rationale: Particulate matter with an aerodynamic diameter ⩽2.5 μm is associated with adverse outcomes in fibrotic interstitial lung disease (fILD), but the impact of ultrafine particulates (UFPs; …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 3
Recent years have seen a growing interest in the early detection of interstitial lung disease (I LD) and its potential implications for clinical care. One of the most promising tools for early ILD detection is computed tomography–based assessment, which has been shown to effectively identify ILD together with interstitial lung abnormalities (ILAs), which refer to incidentally detected features of ILD such as reticulation and honeycombing (1). Because ILAs can progress to overt ILD and are associated with
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 6Ambient Ultrafine Particulate Matter and Clinical Outcomes in Fibrotic Interstitial Lung Disease - 3 day(s) ago
Rationale: Particulate matter with an aerodynamic diameter ⩽2.5 μm is associated with adverse outcomes in fibrotic interstitial lung disease (fILD), but the impact of ultrafine particulates (UFPs; …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 2Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 3 day(s) ago
Chronic obstructive pulmonary disease (COPD) remains a major public health challenge that contributes greatly to mortality and morbidity worldwide. Although it has long been recognized that the epi…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
Gazing into the Proteomic Crystal Ball: Predicting Survival in Idiopathic Pulmonary Fibrosis 🔓 Open Access 🔗 https://t.co/sjgpB9TbJq