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Mashup Score: 43
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody–associated vasculitis (AAV). The PEXIVAS (Plasma Exchange and Glucocorticoids…
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Mashup Score: 5
Precise, early detection of microscopic alterations in interstitial lung disease (ILD) is essential for early diagnosis, as well as to inform prognosis and support therapeutic decision making (1 – 3). Unfortunately, resolution limitations of high-resolution computed tomography (HRCT) make the detection and monitoring of microscopic disease challenging (4). Surgical lung biopsy (SLB) has high risks of associated morbidity and mortality, necessitating a cautious approach for diagnosis and prohibiting use
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Mashup Score: 8The Controversy Continues: Whether to Perform Plasma Exchange, and with What Dose of Steroids, in the PEXIVAS Trial - 6 day(s) ago
The anti–neutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAVs) are a group of rare pauci-immune autoimmune diseases that involve inflammation of the small blood vessels (1). Although how and when these antibodies develop remains a mystery, multiple organs can be left with irreversible damage. Biopsies show few or no immunoglobulins and complement deposits. Notable AAVs include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic GPA, drug-induced vasculitis,
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Mashup Score: 7Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis - 7 day(s) ago
Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 6Zinpentraxin Alfa for Idiopathic Pulmonary Fibrosis: The Randomized Phase III STARSCAPE Trial - 7 day(s) ago
Rationale: A phase II trial reported clinical benefit over 28 weeks in patients with idiopathic pulmonary fibrosis (IPF) who received zinpentraxin alfa. Objectives: To investigate the efficacy and …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 42
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody–associated vasculitis (AAV). The PEXIVAS (Plasma Exchange and Glucocorticoids…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 18
Proof that nintedanib and pirfenidone slow progression of idiopathic pulmonary fibrosis (IPF) has sparked further clinical trials that are being pursued in the hope of curing this devastating disease. This includes the study of pentraxin-2, a liver-synthesized plasma protein with antiinflammatory and antifibrotic properties in in vitro and animal models (1). In this issue of the Journal, Richeldi and colleagues (pp. 1132–1140) report findings of the phase III STARSCAPE randomized controlled trial (RCT)
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Mashup Score: 13
Rationale: Computed tomography (CT) enables noninvasive diagnosis of usual interstitial pneumonia (UIP), but enhanced image analyses are needed to overcome the limitations of visual assessment. Obj…
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Mashup Score: 3Disentangling Computed Tomography Pattern and Extent to Estimate Prognosis in Fibrosing Interstitial Lung Diseases - 10 day(s) ago
Clinicians generally have two objectives when evaluating patients with interstitial lung disease (ILD). The first is to assimilate clinical and phenotypic information to confer a singular ILD diagnosis, which broadly informs medical management and estimated prognosis. The second objective is to identify personal factors that necessitate alterations to the standard diagnosis-based management approach. Several studies have demonstrated that information gained from computed tomography (CT) can advance both
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Mashup Score: 9Idiopathic Pulmonary Fibrosis: From Common Microscopy to Single-Cell Biology and Precision Medicine - 10 day(s) ago
“.” American Journal of Respiratory and Critical Care Medicine, 209(9), pp. 1074–1081 Correspondence and requests for reprints should be addressed to Moisés Selman, M.D., Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas,” Tlalpan 4502, CP 14080, Mexico City, México. E-mail: [email protected]. Author Contributions: M.S. and A.P. contributed to the conception and writing of this manuscript. Not Yet Registered? Benefits of Registration Include: • A Unique User Profile that will allow
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
The Blue Journal thanks Lynn Fussner, MD, for her contribution to the May 1 issue Alveolar Hemorrhage in ANCA–Associated Vasculitis: Results of the PEXIVAS Trial @LynnFussner @lastwalsh https://t.co/jEXP9f5Gly https://t.co/Y5GgSxR95V