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Mashup Score: 14
Introduction: Idecabtagene vicleucel (Ide-Cel) and ciltacabtagene autoleucel (Cilta-cel) are novel CAR-T therapies targeting B-cell maturation antigen (BCMA) and approved for relapsed and refractory multiple myeloma (RRMM). While cardiovascular adverse events (CVAE) are relatively common with CD-19 CAR-T, the incidence of CVAE in the real-world setting for anti-BCMA CAR-T in RRMM is largely unknown. This study aims to determine the incidence of CVAE and its associated risk factors in patients treated with ide-cel and cilta-cel. Method: This single-center retrospective cohort study evaluated RRMM patients treated with ide-cel and cilta-cel from May 2021 to December 2023. We assessed baseline cardiac and oncologic characteristics and clinical outcomes post-CAR-T. Cytokine release syndrome (CRS) and immune cell-associated neurologic syndrome (ICANS) grading followed ASTCT consensus guidelines. Result: A total of 164 RRMM patients treated with ide-cel (N=109) or cilta-cel (N=55) with at le
Source: www.ahajournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 17Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy - 8 day(s) ago
Acute myelopathy is a rare but devastating complication of chimeric antigen receptor (CAR) T-cell therapy for patients with hematological malignancies. Des
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet-
Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy https://t.co/FIfX3DUZRQ
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Mashup Score: 0Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction in extramedullary myeloma - 8 day(s) ago
Key PointsEMD mimics the architectural complexity of solid tumors, marked by diverse microenvironments, multiclonality, and TNFRSF17 and GPRC5D levels.EMD
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet-
Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction in extramedullary myeloma https://t.co/JsyTLcrkSl
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Mashup Score: 19Paper: Transforming Frailty Care in Allo-HCT Candidates: A Prospective Assessment of a Tele-Prehabilitation Project - 12 day(s) ago
Program: Oral and Poster Abstracts Type: Oral Session: 903. Health Services and Quality Improvement: Myeloid Malignancies: Innovative Approaches to Improve Quality of Care, Affordability, and Outcomes Hematology Disease Topics & Pathways: Research, Clinical Practice (Health Services and Quality), Clinical Research, Health outcomes research, Adverse Events, Survivorship Maria Queralt Salas, MD, PhD 1 *, Raquel Salinas González, MD 2 *, Carla Mestre 3 *, Laia Guardia 4 *, Cristina Moreno 5 *, Berta Sole 6
Source: ash.confex.comCategories: General Medicine News, Hem/OncsTweet-
Transforming Frailty Care in Allo-HCT Candidates: A Prospective Assessment of a Tele-Prehabilitation Project https://t.co/dz2V8lfWSl
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Mashup Score: 18Paper: ASH-G Bot: An Artificial Intelligent Chatbot Trained on the American Society of Hematology (ASH) Guidelines - 13 day(s) ago
Program: Oral and Poster Abstracts Session: 803. Emerging Tools, Techniques, and Artificial Intelligence in Hematology: Poster I Hematology Diseas e Topics & Pathways: Research, Artificial intelligence (AI), Epidemiology, Clinical Research, Education, Technology and Procedures Ramy El-Assal 1 * and Aziz Nazha, MD 2 1 The Ohio State University, Columbus 2 Thomas Jefferson University, Department of Medical Oncology, Philadelphia, PA General-purpose language models like ChatGPT, while versatile and proficient
Source: ash.confex.comCategories: General Medicine News, Hem/OncsTweet-
2217 ASH-G Bot: An Artificial Intelligent Chatbot Trained on the American Society of Hematology (ASH) Guidelines https://t.co/Nqduwuh6ic
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Mashup Score: 1
Program: Oral and Poster Abstracts Session: 803. Emerging Tools, Techniques, and Artificial Intelligence in Hematology: Poster III Hematology Disease Topics & Pathways: Research, Artificial intelligence (AI), Adult, Clinical Practice (Health Services and Quality), Clinical Research, Plasma Cell Disorders, Diseases, Immune mechanism, Lymphoid Malignancies, Biological Processes, Emerging technologies, Technology and Procedures, Study Population, Human, Pathogenesis, Machine learning, Pathology Paraic Behan
Source: ash.confex.comCategories: General Medicine News, Hem/OncsTweet-
4983 Application of a Novel Artificial Intelligence Algorithm to Understand Spatial Immune Cell Relationships in Newly Diagnosed Multiple Myeloma https://t.co/Oo0QBbDFxy
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Mashup Score: 19Paper: Transforming Frailty Care in Allo-HCT Candidates: A Prospective Assessment of a Tele-Prehabilitation Project - 13 day(s) ago
Program: Oral and Poster Abstracts Type: Oral Session: 903. Health Services and Quality Improvement: Myeloid Malignancies: Innovative Approaches to Improve Quality of Care, Affordability, and Outcomes Hematology Disease Topics & Pathways: Research, Clinical Practice (Health Services and Quality), Clinical Research, Health outcomes research, Adverse Events, Survivorship Maria Queralt Salas, MD, PhD 1 *, Raquel Salinas González, MD 2 *, Carla Mestre 3 *, Laia Guardia 4 *, Cristina Moreno 5 *, Berta Sole 6
Source: ash.confex.comCategories: General Medicine News, Hem/OncsTweet-
Transforming Frailty Care in Allo-HCT Candidates: A Prospective Assessment of a Tele-Prehabilitation Project https://t.co/dz2V8lfWSl
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Mashup Score: 2Paper: Evaluating Efficacy and Safety of Rapid-Manufactured CD5KO CART5 Cells in Preclinical Models of T Cell Malignancies - 13 day(s) ago
Program: Oral and Poster Abstracts Session: 711. Cell Collection and Manufacturing of HSPCs, CAR-T Cells, and Other Cellular T herapy Products: Poster III Hematology Disease Topics & Pathways: Research, Translational Research 1 Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 2 Vittoria Biotherapeutics, Philadelphia, PA 3 Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 4 Department of Pharmacology
Source: ash.confex.comCategories: General Medicine News, Hem/OncsTweet-
4848 Evaluating Efficacy and Safety of Rapid-Manufactured CD5KO CART5 Cells in Preclinical Models of T Cell Malignancies https://t.co/MxUqhjiLyk
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Mashup Score: 3The EU AI Act: Implications for U.S. Health Care - 15 day(s) ago
The European Union’s Artificial Intelligence Act (AIA), which took effect on August 1, 2024, establishes the world’s first comprehensive legal framework for AI, with significant implications for me…
Source: ai.nejm.orgCategories: General Medicine News, Hem/OncsTweet-
The EU AI Act: Implications for U.S. Health Care | NEJM AI https://t.co/V9qm041T5j
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Mashup Score: 14
While previous studies of artificial intelligence (AI) have shown its potential for diagnosing diseases using imaging data, clinical implementation lags behind. AI models require training with larg…
Source: ai.nejm.orgCategories: General Medicine News, Hem/OncsTweet-
AI-Based Anomaly Detection for Clinical-Grade Histopathological Diagnostics | NEJM AI https://t.co/aASwxX6wHT
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Abstract 4114505: Cardiovascular Adverse Events After Anti-BCMA CAR-T (Ide-Cel and Cilta-Cel) for Relapsed/ Refractory Multiple Myeloma | Circulation https://t.co/HyijqhuEoO