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Mashup Score: 4A Curious Case of Cholestatic Liver Injury - 3 month(s) ago
Question: An Australian-born male in his 60’s was referred to the Gastroenterology clinic after presenting to the emergency department with significantly deranged liver function tests (LFTs). He reported a 2-week history of headaches, pharyngitis, and progressive painless jaundice. Past medical history included type 2 diabetes, depression, benign prostatic hyperplasia, and occasional intravenous drug use, having last injected drugs 3 months before the onset of this illness. Relevant medications included escitalopram, metformin, tamsulosin, and aspirin for several years, and he had recently commenced rosuvastatin, which was ceased at time of presentation to emergency.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 8Development and Implementation of a Clinical Decision Support Tool to Improve Adherence to Colonoscopy Follow-Up Guidelines - 3 month(s) ago
The US Multi-Society Task Force on Colorectal Cancer (CRC) recommends follow-up colonoscopy based on examination quality, clinical factors, and polyp findings.1 Despite this, overuse and underuse of colonoscopy remain significant problems.2–5 The American College of Gastroenterology/American Society for Gastrointestinal Endoscopy Colonoscopy Quality Task Force recommends appropriate surveillance recommendations (ASR) as a priority quality indicator.6 However, tracking ASRs for individual endoscopists requires labor-intensive manual chart review.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 6Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults - 3 month(s) ago
In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in 10 new diagnoses of CRC are now made in individuals 50 years or younger. Patients’ risk of CRC has been calculated largely by age and family history, yet 3 of 4 patients with early-onset CRC have no family history of the disease. Rapidly increasing incidence rates in younger people could result from generational differences in diet, environmental exposures, and lifestyle factors.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 18Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases - 3 month(s) ago
In the largest study of its kind, we identified key molecular changes that contribute to the spread of stomach cancer to the peritoneum (the lining of the abdomen).
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 3Crohn’s Patients and Healthy Infants Share Immunodominant B Cell Response to Commensal Flagellin Peptide Epitopes - 3 month(s) ago
Patients with Crohn’s disease and healthy infants share a dominant immunoglobulin G antibody response to the “hinge region” of Lachnospiraceae flagellins, suggesting that failure of establishing homeostasis with the gut microbiota in infancy may contribute to the development of Crohn’s disease later in life.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 1Atlas of Metastatic Gastric Cancer Links Ferroptosis to Disease Progression and Immunotherapy Response - 3 month(s) ago
A comprehensive single-cell tumor and immune atlas of metastatic gastric adenocarcinomas is presented, uncovering molecular and cellular dynamics during metastasis and proposing a novel therapeutic strategy with potential clinical implications.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 39Adverse Events Associated with Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-analysis - PubMed - 3 month(s) ago
ERCP-associated AEs remain common. Incidence of post-ERCP pancreatitis remained static despite improvements in techniques, prevention, and recognition. These results are important to patients, endoscopists, and policy makers to inform consent and to encourage implementation of available risk mitigat …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 22
In a public health model in resource-constrained regions, treatment of hepatitis C virus with generic, free-of-cost, directly acting antiviral agents in patients with decompensated cirrhosis leads to recompensation in about one-fourth of patients.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 28Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets - 3 month(s) ago
The pathophysiology of Crohn’s-like disease of the pouch in patients with a prior history of ulcerative colitis is revealed and new targets to better treat this challenging condition are identified.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 7Exon Skipping-based Subtyping of Colorectal Cancers - 3 month(s) ago
The identification of colorectal cancer (CRC) molecular subtypes has prognostic and potentially diagnostic value for patients, yet reliable subtyping remains unavailable in the clinic. The current consensus molecular subtype (CMS) classification in colorectal cancers is based on complex RNA expression patterns quantified at gene level. The clinical application of these methods, however, is challenging due to high uncertainty of single sample classification and associated costs. Alternative splicing (AS), which strongly contributes to transcriptome diversity, has rarely been utilized for tissue type classification.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
📸 Gastro Curbside Consult presents a curious case of cholestatic liver injury. Can you figure out the diagnosis? 🔗 https://t.co/v8LIfzq8kD #LiverTwitter #Gastroenterology https://t.co/4VanvE2swT