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Mashup Score: 9Noncanonical TRAIL Signaling Promotes Myeloid-Derived Suppressor Cell Abundance and Tumor Growth in Cholangiocarcinoma - 18 day(s) ago
Proapoptotic tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) signaling as a cause of cancer cell death is a well-established mechanism. However, TRAIL-receptor (TRAIL-R) agonists have had very limited anticancer activity in human beings, challenging the concept of TRAIL as a potent anticancer agent. Herein, we aimed to define mechanisms by which TRAIL+ cancer cells can leverage noncanonical TRAIL signaling in myeloid-derived suppressor cells (MDSCs) promoting their abundance in murine cholangiocarcinoma (CCA).
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 137Hepatorenal Syndrome in Cirrhosis - 19 day(s) ago
Hepatorenal syndrome (HRS) is a form of kidney dysfunction that characteristically occurs in liver cirrhosis. It is characterized by a marked impairment of kidney function in response to circulatory and hemodynamic alterations that occur in advanced stages of liver cirrhosis, aggravated by systemic inflammation and bacterial translocation. The classical definitions of the types of HRS have been recently revisited and 2 forms of HRS have been redefined: the acute form, referred to as acute kidney injury (HRS-AKI), and the chronic form, referred to as chronic kidney disease.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 10A Seemingly Benign Pancreatic Cyst With an Unsettling Trend of Enlarging Size and Associated Symptoms - 21 day(s) ago
Question: A 62-year-old woman was incidentally diagnosed with a well circumscribed hypoattenuating cyst in the head of the pancreas during a computed tomographic (CT) scan while being evaluated for nonspecific colitis. Subsequent magnetic resonance imaging confirmed the presence of a well circumscribed, T1-hypointense, T2-hyperintense cystic mass measuring 3.5 × 3.3 cm in the head of the pancreas (Figure A). Mild dilation was observed in the common bile duct secondary to an earlier cholecystectomy.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 107Concepts and Controversies in Eosinophilic Esophagitis: What’s Coming Down the Pipe? - 22 day(s) ago
This patient’s case history (void of protected health information) was discussed in a multidisciplinary meeting including an adult gastroenterologist (KP), pediatric gastroenterologist (MHC), pediatric allergist (SSA) and gastrointestinal pathologist (MC) with an adult gastroenterologist (NG) as a moderator. We summarize the case history and discussion in this article.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 14Replication Efficiency of SARS-CoV-2 Omicron Subvariants BA.2.75, BA.5, and XBB.1 in Human Mini-Gut Organoids - 25 day(s) ago
We and others have reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19), can propagate in human intestinal organoids.1,2 We also demonstrated that the Omicron BA.1 and BA.2 lineages have reduced replication efficiency compared with the Delta variant.1 Recently, the Omicron subvariants, namely BA.2.75, BA.5, and XBB.1, have emerged and became prevalent worldwide; however, their ability to replicate and persist in the intestinal tract is not well understood.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 115Standard of Care Versus Octreotide in Angiodysplasia-Related Bleeding (the OCEAN Study): A Multicenter Randomized Controlled Trial - 26 day(s) ago
Octreotide treatment was compared with standard of care in an adequately powered randomized controlled trial, which established that octreotide significantly reduces transfusion requirements and endoscopic procedures in patients with angiodysplasia-related anemia.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 23Current Issue Table of Contents: Gastroenterology - 27 day(s) ago
Login with your AGA username and password. Volume 165 Issue 2 p307-522,
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 9Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation - 28 day(s) ago
A primary biliary cholangitis causal mutation contributes to the pathogenic interaction of immune cells with the cells lining the bile ducts that also have a specific inflammation-driving role.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 2An Institutional Overview of Gastrointestinal Bleeding Among 563 Continuous Flow Left Ventricular Assist Device Recipients - 1 month(s) ago
: Gastrointestinal bleeding (GIB) is a common morbidity among continuous flow-left ventricular assist device (CF-LVAD) recipients. The study objectives were to investigate the incidence, recurrence, risk factors and the medical and endoscopic management of GIB among CF-LVAD patients.
Source: www.tigejournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 9Influence of Procedural Volume on the Outcome of Gastric Endoscopic Submucosal Dissection: A Nationwide Population-Based Study Using Administrative Data - 1 month(s) ago
The risk of adverse outcomes of endoscopic resection of stomach neoplasms vary per hospital depending on the volume of procedures. These data could be important in terms of patient safety.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
Study finds noncanonical TRAIL signaling promotes myeloid-derived suppressor cell abundance and tumor growth in #cholangiocarcinoma. 🌟 Learn more at https://t.co/uvRy4QOmaj https://t.co/wQlzRHSc0Y