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Mashup Score: 3
Pupils from Riverdale Primary School have been learning about dementia from older people with the disease.
Source: www.bbc.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Aussie telehealth startup Updoc gets $13M funding from Bailador - 2 hour(s) ago
It is now set to take on the international markets three years after its inception.
Source: www.mobihealthnews.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 2How AI can boost cancer, depression and perioperative care - 2 hour(s) ago
IEEE Fellow Chenyang Lu shows where artificial intelligence can be deployed clinically to improve patient outcomes – and discusses the challenges and future of AI throughout healthcare.
Source: www.healthcareitnews.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 2
Dorset Community Foundation has awarded the funding to 22 groups across the county.
Source: www.bbc.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1A high content imaging assay for identification of specific inhibitors of native Plasmodium liver stage protein synthesis - 2 hour(s) ago
Plasmodium parasite resistance to antimalarial drugs is a serious threat to public health in malaria-endemic areas. Compounds that target core cellular processes like translation are highly desirable, as they should be multistage actives, capable of killing parasites in the liver and blood, regardless of molecular target or mechanism. Assays that can identify these compounds are thus needed. Recently, specific quantification of native Plasmodium berghei liver stage protein synthesis as well as that of the hepatoma cells supporting parasite growth, was achieved via automated confocal feedback microscopy of the o-propargyl puromycin (OPP)-labeled nascent proteome, but this imaging modality is limited in throughput. Here, we developed and validated a miniaturized high content imaging (HCI) version of the OPP assay that increases throughput, before deploying this approach to screen the Pathogen Box. We identified only two hits, both of which are parasite-specific quinoline-4-carboxamides,
Source: www.biorxiv.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2 - 2 hour(s) ago
SARS-CoV-2 infection and COVID-19 disease vary with respect to viral variant and host vaccination status. However, how vaccines, emergent variants, and their intersection shift host responses in the human nasal mucosa remains uncharacterized. We and others have shown during the first SARS-CoV-2 wave that a muted nasal epithelial interferon response at the site of infection underlies severe COVID-19. We sought to further understand how upper airway cell subsets and states associate with COVID-19 phenotypes across viral variants and vaccination. Here, we integrated new single-cell RNA-sequencing (scRNA-seq) data from nasopharyngeal swabs collected from 67 adult participants during the Delta and Omicron waves with data from 45 participants collected during the original (Ancestral) wave in our prior study. By characterizing detailed cellular states during infection, we identified changes in epithelial and immune cells that are both unique and shared across variants and vaccination status.
Source: www.biorxiv.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1'Seagull Boy' is VIP guest at Natural History Museum - 2 hour(s) ago
Nine-year-old Cooper was a VIP guest at the Natural History Museum.
Source: www.bbc.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Free relaxation therapy for Jersey cancer charity - 2 hour(s) ago
Staff and volunteers at Macmillan Jersey were given free treatments at Highlands College.
Source: www.bbc.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Dissecting the ocular impact of SARS-CoV-2 variants: Analysis of eye globe and retina in animal models - 2 hour(s) ago
Neurological and ocular manifestations were reported in COVID-19 patients and in SARS-CoV-2 infected animal models. However, the effects of SARS-CoV-2 variants of concern (VoC) on the eyes and the retina remain unclear. Here, we investigate the cellular and molecular consequences of SARS-CoV-2 VoC infection on the eye and retina in mice and hamsters. Infection with the ancestral SARS-CoV-2 and the Gamma VoC induced a subtle increase in the eye volume of K18-hAce2 mice, but no morphological alteration was observed in hamsters eyes. Evaluation of the ocular tropism revealed that distinct SARS-CoV-2 VoC reached the eye globe, but not the retina of K18-hAce2 mice. In contrast, SARS-CoV-2 variants are detected in the hamsters retina during both acute infection and after disease recovery. Despite the presence of viral RNA, no inflammation was observed in the hamster retina, as evidenced by unchanged microglial cell density and unaltered gene expression of several immune mediators. Altogether
Source: www.biorxiv.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4Berkshire's Big Picture: 27 May - 2 June 2024 - 2 hour(s) ago
Showcasing the best images sent to us from around Berkshire.
Source: www.bbc.comCategories: General Medicine News, General HCPsTweet
'The kids remind you of the way you used to be' https://t.co/N35XOfqmv9