TOPS – WFU Health & Exercise Science
The objective of this Phase III, multi-site (Boston, MA, Chapel Hill, NC, Sydney, Australia, and Winston-Salem, NC) randomized clinical trial is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee OA prevention. Site PI: Shannon Mihalko, PhD Site PI: Leigh Callahan, PhD Site PI: Elena Losina, PhD, MSc Data Coordinating Center: Edward Ip, PhD Data Coordinating Center: Jimi Cook, DVM, PhD, OTSC A 48-month healthy lifestyle program Classes