Top 20 high-impact clinical research articles of 2024
Our editors-in-chief share their selection of must-read clinical research articles from the past year.
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Challenge of treatment de-escalation in inflammatory bowel diseases
Inflammatory bowel diseases (IBDs) encompass chronic conditions predominantly affecting young individuals and necessitate long-term, advanced treatments to manage disease burden and mitigate progressive tissue damage.1…
Aspirin after completion of standard adjuvant therapy for colorectal cancer (ASCOLT): an international, multicentre, phase 3, randomised, double-blind, placebo-controlled trial
In patients with colorectal cancer, aspirin 200 mg daily for 3 years after completion of standard adjuvant therapy was well tolerated but did not significantly…
What Gastroenterologists Should Know About Microplastics… : Journal of Clinical Gastroenterology
oxic effects, MNPs can adsorb harmful contaminants and act as vectors for microorganisms, compounding toxicological effects. After entering the body, bioaccumulation occurs in several tissues…
Proteomic Biomarkers in Serum Predict Villous Atrophy Development in Asymptomatic Potential Celiac Disease Children at Time of Diagnosis
Potential celiac disease (PCD) is characterized by the presence of anti-tissue transglutaminase antibodies and normal intestinal architecture.1
2025 January Author Interview-Sheza Malik
Dr Sheza Malik discusses her article, “Efficacy and safety of gastric peroral endoscopic myotomy across different etiologies of gastroparesis: systematic rev…
Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control
Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways that regulate macrophage…
‘Alarming’ rise in alcohol-associated hepatitis reported in female teenagers, young adults
From 2002 to 2021, the incidence rate of alcohol-associated hepatitis “more than doubled” among adolescents and young adults in Ontario, Canada, with the highest uptick…
Construction of exosome non-coding RNA feature for non-invasive, early detection of gastric cancer patients by machine learning: a multi-cohort study
Background and objective Gastric cancer (GC) remains a prevalent and preventable disease, yet accurate early diagnostic methods are lacking. Exosome non-coding RNAs (ncRNAs), a type…
Role of Sex, Anxiety, and Resilience in the Association Between Adverse Childhood Experiences and Irritable Bowel Syndrome
Adverse childhood experiences (ACE) are associated with increased risk of irritable bowel syndrome (IBS), a female-predominant chronic abdominal disorder. Factors contributing to this association have…
