The human immune system contains a vast repertoire of somatically recombined T cell receptor (TCR) sequences. To connect TCR sequence to T cell function, Lagattuta et al. analyze the paired αβTCR and transcriptome of >960,000 T cells. They identify TCR amino acids that promote T cell activation and immunological memory.
Timothy Brown, MD, UT Southwestern Medical Center, Dallas, TX, highlights the importance of dialogue between patients and clinicians regarding the side effects and treatment logistics…
Ischemic stroke and vascular cognitive impairment are global health threats. Recent research has uncovered a previously underappreciated dynamic interplay between brain-resident, meningeal, and systemic immune…
Descubre cómo implementar el método de aula invertida en tu clase y potencia la participación de tus estudiantes.
Hope S. Rugo, MD, of the University of California San Francisco, and Kate Lathrop, MD, SABCS Program Director, discuss the recent FDA approval of datopotamab…
PURPOSEThis multicenter, randomized, phase III clinical trial (Northern Radiation Oncology Group of China-002) focused on patients with oligo-organ metastatic non–small cell lung cancer (NSCLC) who…
Lukas Nystrom, MD, Orthopaedic Oncology Surgeon and a Co-Director of the Sarcoma Program at Cleveland Clinic joins the Cancer Advances Podcast to talk about the…
Guo et al. trace immune cell dynamics in patients with hepatocellular carcinoma (HCC) receiving neoadjuvant anti-PD-1 plus lenvatinib by single-cell multi-omics technologies. Compared with anti-PD-1 monotherapy,…
Acute toxicity following prostate radiotherapy was statistically significantly associated with late toxicity and with decrement in patient-reported QOL metrics. These data support efforts to evaluate…
The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular…
