The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis
Pulmonary fibrosis therapies require improved understanding of the underlying inflammatory mechanisms of disease. Liu et al. demonstrate that immune-derived CCL1 promotes lung fibrosis by two pathways: (1) recruiting CCR8-expressing fibroblasts to the lung and (2) activating lung fibroblasts into pathological myofibroblasts by binding AMFR on fibroblasts, which enhances Ras-ERK signaling and…
