The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models
Novak et al. show how Miro1 regulates mitochondrial transfer from the tumor microenvironment to mtDNA-deficient melanoma cells. The authors argue that delayed tumor formation observed in Miro1KO mice results from impaired mitochondrial transfer, which involves reduced microtubule association, disruption of the mitochondrial network, and TNT formation.