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Mashup Score: 36
Type 1 diabetes is around twice as common in the offspring of men with type 1 diabetes than in the offspring of women with type 1 diabetes, but the reasons for this difference are unclear. This Review summarises the evidence on the rate of transmission of type 1 diabetes to the offspring of affected fathers compared with affected mothers. The findings of nine major studies are presented, describing the magnitude of the effect observed and the relative strengths and weaknesses of these studies. This Review also explores possible underlying mechanisms for this effect, such as genetic mechanisms (eg, the selective loss of fetuses with high-risk genes in mothers with type 1 diabetes, preferential transmission of susceptibility genes from fathers, and parent-of-origin effects influencing gene expression), environmental exposures (eg, exposure to maternal hyperglycaemia, exogenous insulin exposure, and transplacental antibody transfer), and maternal microchimerism.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 26
Type 1 diabetes is around twice as common in the offspring of men with type 1 diabetes than in the offspring of women with type 1 diabetes, but the reasons for this difference are unclear. This Review summarises the evidence on the rate of transmission of type 1 diabetes to the offspring of affected fathers compared with affected mothers. The findings of nine major studies are presented, describing the magnitude of the effect observed and the relative strengths and weaknesses of these studies. This Review also explores possible underlying mechanisms for this effect, such as genetic mechanisms (eg, the selective loss of fetuses with high-risk genes in mothers with type 1 diabetes, preferential transmission of susceptibility genes from fathers, and parent-of-origin effects influencing gene expression), environmental exposures (eg, exposure to maternal hyperglycaemia, exogenous insulin exposure, and transplacental antibody transfer), and maternal microchimerism.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 12ENP79: Type 1 Diabetes Update - 4 month(s) ago
Host Aaron Lohr talks with Irl Hirsch from the University of Washington, co-chair of the Endocrine Society’s type 1 diabetes fellows program.
Source: www.endocrine.orgCategories: General Medicine News, EndocrinologyTweet-
Type 1 Diabetes Update | Listen to Irl Hirsch, MD, talk about our #Type1Diabetes Fellows program and the latest in #T1D research and treatment, as well as forecast for future technology and treatment opportunities in this @Endocrine_News Podcast episode: https://t.co/q7TJ1FXFij https://t.co/pWLVUhzIGB
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Mashup Score: 0FDA Clears Omnipod 5 App for iPhones - 5 month(s) ago
The FDA has granted 510(k) Clearance to the Omnipod 5 app for iPhone, making Insulet Corporation the first to offer a tubeless AID system with smartphone control.
Source: www.hcplive.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 0FDA Clears Omnipod 5 App for iPhones - 7 month(s) ago
The FDA has granted 510(k) Clearance to the Omnipod 5 app for iPhone, making Insulet Corporation the first to offer a tubeless AID system with smartphone control.
Source: www.hcplive.comCategories: General Medicine News, General NewsTweet
REVIEW: Maternal #type1diabetes and relative protection against offspring transmission T1D is around twice as common in the offspring of men with T1D than in women with #T1D, but the reasons for this difference are unclear. To find out more see: https://t.co/q505h06Lm9