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Mashup Score: 0Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid - 7 hour(s) ago
Key PointsAPC is a pleiotropic protease with diverse functions derived from its anticoagulant, anti-inflammatory, and cytoprotective activities.Single amin
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 2The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding - 9 hour(s) ago
Key PointsIndividuals homozygous for the F5 G haplotype (F5-G/G) have increased alternative F5 splicing that leads to increased plasma FV-short levels.F5-G
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0Use of Affimer technology for inhibition of α2-antiplasmin and enhancement of fibrinolysis - 11 hour(s) ago
Key PointsFunction of antifibrinolytic protein α2AP can be modulated using Affimers, facilitating lysis of clots from plasma and whole blood samples.α2AP-s
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 19Factor XI inhibitors: a new class of anticoagulants - 5 day(s) ago
FXI/FXIa inhibition may allow for inhibition of contact pathway activation of thrombin generation depicted on the right side of the coagulation cascade, wh
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 17Factor XI inhibitors: a new class of anticoagulants - 5 day(s) ago
FXI/FXIa inhibition may allow for inhibition of contact pathway activation of thrombin generation depicted on the right side of the coagulation cascade, wh
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 10Decoding cost-effectiveness of PNH therapies - 15 day(s) ago
In this issue of Blood, Ito et al1 present a compelling cost-effectiveness analysis of iptacopan for patients with paroxysmal nocturnal hemoglobinuria (PNH
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 10Decoding cost-effectiveness of PNH therapies - 15 day(s) ago
In this issue of Blood, Ito et al1 present a compelling cost-effectiveness analysis of iptacopan for patients with paroxysmal nocturnal hemoglobinuria (PNH
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 9Licking the wound with procoagulant vesicles - 29 day(s) ago
In this issue of Blood, Thaler and colleagues define the role of salivary procoagulant extracellular vesicles (EVs) by demonstrating the differences in sam
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 15Saliva of persons with hemophilia A triggers coagulation via extrinsic tenase complexes - 1 month(s) ago
Key PointsExtrinsic tenase complexes are present in saliva of persons with hemophilia A and absent in saliva of persons with FVII deficiency.Presence or ab
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 17Polyreactive IgM: a trigger for aHUS - 1 month(s) ago
In this issue of Blood, Cole et al,1 using a novel cellular “biosensor” model, uncover that polyreactive immunoglobulin M (IgM)-initiated classical complem
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
Single amino acid differences in the CDRs of APC-targeting antibodies are sufficient to divergently modulate APC’s pleiotropic functions. https://t.co/RvLiHzz85x #thrombosisandhemostasis https://t.co/Ey9i98w0By