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Mashup Score: 4Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion - 28 day(s) ago
A human germline-mosaic for WT and DNMT3A mutant cells reveals a marked advantage for DNMT3A mutant cells in the hematopoietic system compared to epithelial cells. Deep sequencing suggests a very early tissue advantage driven by DNA methylation loss at conserved loci rather than increased mutation burden.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
Embryonic-derived mosaicism is likely highly under-appreciated and yet can have significant implications for the identification, management, and transmission of a variety of conditions. Eg #TBRS #DNMT3A @TBRSCommunity https://t.co/KcLRUEheA9