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Mashup Score: 20Standardisation of Definition and Management for Bleeding Disorder of Unknown Cause: Communication from the SSC of the ISTH. - 1 year(s) ago
In many patients referred with significant bleeding phenotype, laboratory testing fails to define any hemostatic abnormalities. Clinical practise with respect to diagnosis and management of this patient cohort poses significant clinical challenges. We recommend that bleeding history in these patients should be objectively assessed using the ISTH bleeding assessment tool (BAT). Patients with increased BAT scores should progress to hemostasis laboratory testing. To diagnose BDUC, normal complete blood count, prothrombin time, activated partial thromboplastin time, thrombin time, von Willebrand factor antigen, von Willebrand factor function; coagulation factors VIII, IX and XI and platelet light transmission aggregometry (LTA) should be the minimum laboratory assessment.
Source: www.jthjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2
As much as 43% of patients with systemic sclerosis demonstrate evidence of myopathy, while those with proximal weakness and higher creatine kinase exhibit worse function and survival, according to data. “We know that a lot of people living with systemic sclerosis, or scleroderma, have muscle problems,” Jessica L. Fairley, MBBS, of the University of Melbourne, in Australia, told
Source: www.healio.comCategories: General Medicine News, RheumatologyTweet-
💥As much as 43% of patients with #SSc show evidence of myopathy 💥Those with proximal weakness and higher creatine kinase have worse function and survival Check Healio for more about this study out of @UniMelb 🔽 https://t.co/Gdf0Yfjmah
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Mashup Score: 32CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion - 1 year(s) ago
Objectives Cytotoxic T cells and natural killer (NK) cells are central effector cells in cancer and infections. Their effector response is regulated by activating and inhibitory receptors. The regulation of these cells in systemic autoimmune diseases such as systemic sclerosis (SSc) is less defined. Methods We conducted ex vivo analysis of affected skin and blood samples from 4 SSc patient cohorts (a total of 165 SSc vs 80 healthy individuals) using single-cell transcriptomics, flow cytometry and multiplex immunofluorescence staining. We further analysed the effects of costimulatory modulation in functional assays, and in a severely affected SSc patient who was treated on compassionate use with a novel anti-CD3/CD7 immunotoxin treatment. Results Here, we show that SSc-affected skin contains elevated numbers of proliferating T cells, cytotoxic T cells and NK cells. These cells selectively express the costimulatory molecule CD7 in association with cytotoxic, proinflammatory and profibrot
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet-
📣 CD7 as novel therapeutic target in #SSc! 🔹 expressed by activated T cells and natural killer cells 🔹 associated with a proinflammatory and profibrotic gene signature 🔹 depletive treatment stabilised disease in a severely affected SSc patient https://t.co/ko8PFIdymS https://t.co/wHi2lp1k8D
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Mashup Score: 31Performance of myotonometer in the assessment of skin involvement in systemic sclerosis - Clinical Rheumatology - 1 year(s) ago
Objectives A clinically practical tool to assess skin biomechanical properties rapidly and accurately is still lacking. Our aim was to examine the intra- and inter-observer reproducibility of a myotonometer for objective skin property assessment in systemic sclerosis (SSc), comparing it with the modified Rodnan skin score (mRSS), and distinguishing patients from healthy controls. Method…
Source: link.springer.comCategories: General Medicine News, RheumatologyTweet-
✅Myotonometer displays excellent intra- and inter-examiner reproducibility for assessing skin properties ✅Skin tone and stiffness parameters well correlated with mRSS scores ✅Can distinguish patients with diffuse cutaneous #SSc from healthy controls 👉https://t.co/CchFMWAJC0 https://t.co/UlA0xoDyuC
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Mashup Score: 2
Full Papers; Authors: C. Tolosa-Vilella, M. Del mar rodero-Roldán, A. Guillen-Del-Castillo, A. Marín-Ballvé, R. Boldova-Aguar, B. Marí-Alfonso, C. Feijoo-Massó, D. Colunga-Argüelles, M. Rubio-Rivas, L. Trapiella-Martínez, N. Iniesta-Arandia, E. Callejas-Moraga, F.J. García-Hernández, L. Sáez-Comet, C. González-Echávarri, N. Ortego-Centeno, M. Freire, J.A. Vargas-Hitos, J.J. Ríos-Blanco, J.A. Todolí-Parra, I. Rodríguez-Pintó, A.-J. Chamorro, X. Pla-Salas, A.B. Madroñero-Vuelta, M. Ruiz-Muñoz, V. Fonollosa-Pla, C.P. Simeón-Aznar the RESCLE Investigators
Source: www.clinexprheumatol.orgCategories: General Medicine News, RheumatologyTweet-
NVC in 1356 #SSc registry pts classified as early, active or‘late. Late pattern seen in 40%: signific. assoc w/ dcSSc (OR=1.96), ILD (OR=1.29), renal crisis (OR=3.46), digital ulcer (OR=1.29), & topoisomerase I Abs (OR=1.39) https://t.co/RgET0HbImf https://t.co/Ex3nKto6JW
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Mashup Score: 3Interstitial Lung Disease Clinical Practice Guidelines - 2 year(s) ago
Read recommendations for the screening, monitoring, and treatment of interstitial lung disease (ILD) in patients with systemic autoimmune rheumatic disease.
Source: rheumatology.orgCategories: Latest Headlines, RheumatologyTweet-
Two new ACR Clinical Practice Guideline Summaries provide recommendations regarding screening, monitoring, & treatment of #ILD in people with systemic autoimmune #rheum diseases, including #RA, #SSc, & idiopathic inflammatory myopathies. View → https://t.co/WGMZo6LEZh https://t.co/VNYlmymKdh
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Mashup Score: 0
Nintedanib slows the deterioration of lung functionality in patients with limited cutaneous systemic sclerosis and interstitial lung disease, according to data published in Rheumatology.
Source: www.healio.comCategories: Latest Headlines, RheumatologyTweet-
“These analyses of data from the SENSCIS trial indicate that patients with lcSSc may develop progressive pulmonary fibrosis within a few years of diagnosis of #SSc.” #MedTwitter https://t.co/QKlpDsXbyM
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Mashup Score: 0
Full Papers; Authors: C. Tolosa-Vilella, M. Del mar rodero-Roldán, A. Guillen-Del-Castillo, A. Marín-Ballvé, R. Boldova-Aguar, B. Marí-Alfonso, C. Feijoo-Massó, D. Colunga-Argüelles, M. Rubio-Rivas, L. Trapiella-Martínez, N. Iniesta-Arandia, E. Callejas-Moraga, F.J. García-Hernández, L. Sáez-Comet, C. González-Echávarri, N. Ortego-Centeno, M. Freire, J.A. Vargas-Hitos, J.J. Ríos-Blanco, J.A. Todolí-Parra, I. Rodríguez-Pintó, A.-J. Chamorro, X. Pla-Salas, A.B. Madroñero-Vuelta, M. Ruiz-Muñoz, V. Fonollosa-Pla, C.P. Simeón-Aznar the RESCLE Investigators
Source: www.clinexprheumatol.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
Nailfold videocapillaroscopy (NVC) in 1356 #SSc registry pts classified as early, active or‘late. Late pattern seen in 40%: signific. assoc w/ dcSSc (OR=1.96), ILD (OR=1.29), renal crisis (OR=3.46), digital ulcer (OR=1.29), & topoisomerase I Abs (OR=1.39) https://t.co/jxXKuWncd2 https://t.co/1XfVw31oqr
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Mashup Score: 18
Full Papers; Authors: C. Tolosa-Vilella, M. Del mar rodero-Roldán, A. Guillen-Del-Castillo, A. Marín-Ballvé, R. Boldova-Aguar, B. Marí-Alfonso, C. Feijoo-Massó, D. Colunga-Argüelles, M. Rubio-Rivas, L. Trapiella-Martínez, N. Iniesta-Arandia, E. Callejas-Moraga, F.J. García-Hernández, L. Sáez-Comet, C. González-Echávarri, N. Ortego-Centeno, M. Freire, J.A. Vargas-Hitos, J.J. Ríos-Blanco, J.A. Todolí-Parra, I. Rodríguez-Pintó, A.-J. Chamorro, X. Pla-Salas, A.B. Madroñero-Vuelta, M. Ruiz-Muñoz, V. Fonollosa-Pla, C.P. Simeón-Aznar the RESCLE Investigators
Source: www.clinexprheumatol.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
Nailfold videocapillaroscopy (NVC) in 1356 #SSc registry pts classified as early, active or‘late. Late pattern seen in 40%: signific. assoc w/ dcSSc (OR=1.96), ILD (OR=1.29), renal crisis (OR=3.46), digital ulcer (OR=1.29), & topoisomerase I Abs (OR=1.39) https://t.co/5CjWnFCfT5 https://t.co/CY4aCB9iAH
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Mashup Score: 12EULAR recommendations for the non-pharmacological management of systemic lupus erythematosus and systemic sclerosis - 2 year(s) ago
Objective To develop evidence-based recommendations for the non-pharmacological management of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Methods A task force comprising 7 rheumatologists, 15 other healthcare professionals and 3 patients was established. Following a systematic literature review performed to inform the recommendations, statements were formulated, discussed…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
EULAR recommendations for the non-pharmacological management of #SLE and #SSc 📕 patient education and self-management 🚭 cessation of smoking ❄️ avoidance of cold exposure 🤸 physical exercise and more... Read the full recommendations here 👇 https://t.co/PPmOMtEMeb
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Read the latest Communication from the @ISTH #SSC on "Standardisation of Definition and Management for Bleeding Disorders of Unknown Cause" in @JTHjournal https://t.co/dMuxgOdu0H https://t.co/shsgk4emDb