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Mashup Score: 16
Background: Congenital diaphragmatic hernia (CDH) is a complex congenital disorder often accompanied by long-term feeding difficulties. There is a paucity of published data regarding the impact of swallowing difficulties on long-term patient outcomes. Our study attempts to evaluate this phenomenon. Methods: A retrospective chart review of infants born with CDH between 2021 and 2022 identified 45 patients. The following variables were identified: need for swallow study, stomach location, defect type, need for anti-reflux therapy, need for nasogastric tube (NG) or gastric tube (GT) at time of discharge, poor growth, and frequency of respiratory infections during the first 12 months of life. Results: Thirty-one percent of patients (n = 14) underwent a swallow study, 20% (n = 9) required long-term anti-reflux medications, 18% (n = 8) had a GT and 59% (n = 26) had an NG in place at time of discharge, 44% (n = 17) experienced poor growth as an outpatient, and 35% (n = 16) had respiratory inf
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 10Assessment of Physical Performance in Children After Surgery for Congenital Diaphragmatic Hernia - 1 month(s) ago
Objective: This study aims to evaluate long-term physical and motor performance in children aged 3–6 years following congenital diaphragmatic hernia (CDH) surgery, in comparison with healthy peers. While existing research emphasizes prognostic factors such as the lung to heart ratio (LHR) and liver position, few studies address physical outcomes in early childhood post-surgery. Methods: A total of 31 children who underwent neonatal CDH surgery (study group) and 41 age-matched healthy children (reference group) were assessed. The Wrocław Test and the Ozierecki Metric Scale (modified by Barański) were used to evaluate strength, endurance, motor coordination, and agility. Results: Findings indicated that children in the CDH group had significantly lower scores in physical performance, particularly in endurance and motor coordination, compared to their healthy peers. Strength differences were present but less pronounced. Conclusions: Children post-CDH surgery exhibit slightly delayed physi
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet-
Assessment of Physical Performance in Children After Surgery for Congenital Diaphragmatic Hernia #some4pedsurg #some4surgery #CDH https://t.co/KMZkBQOEVB
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Mashup Score: 9Association between Time with Open Ductus Arteriosus and Outcomes in Congenital Diaphragmatic Hernia - 2 month(s) ago
Abstract. Introduction: While a patent ductus arteriosus (PDA) helps offload the right ventricle in the acute congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension, its role on long-term outcomes in CDH has not been investigated. Our objective was to examine associations of the PDA with long-term clinical outcomes in CDH. Methods: A single-center retrospective descriptive study of 122 CDH patients dichotomized by duration with PDA, as ≤14 versus >14 postnatal days (PND) and ≤30 versus >30 PND. Fisher’s exact test, Wilcoxon rank-sum test, and multiple linear and logistic regression analyses were used for analyses. Results: In unadjusted and adjusted for CDH severity comparisons, patients with PDA >14 PND and >30 PND had a higher risk of death, longer length of stay, mechanical ventilation duration, and need for tracheostomy, diuretics, and PH medications at discharge. Conclusion: A PDA beyond the newborn period is associated with adverse outcomes in infants with CDH.
Source: karger.comCategories: General Medicine News, General HCPsTweet-
Association between Time with Open Ductus Arteriosus and Outcomes in Congenital Diaphragmatic Hernia #some4pedsurg #some4surgery #CDH https://t.co/EKJJTcnsrl
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Mashup Score: 6Association between Time with Open Ductus Arteriosus and Outcomes in Congenital Diaphragmatic Hernia - 2 month(s) ago
Abstract. Introduction: While a patent ductus arteriosus (PDA) helps offload the right ventricle in the acute congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension, its role on long-term outcomes in CDH has not been investigated. Our objective was to examine associations of the PDA with long-term clinical outcomes in CDH. Methods: A single-center retrospective descriptive study of 122 CDH patients dichotomized by duration with PDA, as ≤14 versus >14 postnatal days (PND) and ≤30 versus >30 PND. Fisher’s exact test, Wilcoxon rank-sum test, and multiple linear and logistic regression analyses were used for analyses. Results: In unadjusted and adjusted for CDH severity comparisons, patients with PDA >14 PND and >30 PND had a higher risk of death, longer length of stay, mechanical ventilation duration, and need for tracheostomy, diuretics, and PH medications at discharge. Conclusion: A PDA beyond the newborn period is associated with adverse outcomes in infants with CDH.
Source: karger.comCategories: General Medicine News, General HCPsTweet-
Association between Time with Open Ductus Arteriosus and Outcomes in Congenital Diaphragmatic Hernia #some4pedsurg #some4surgery #CDH https://t.co/EKJJTcnsrl
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Mashup Score: 14Increased Elastase and Matrix Metalloproteinase Levels in the Pulmonary Arteries of Infants with Congenital Diaphragmatic Hernia - 11 month(s) ago
Pulmonary vascular disease (PVD) complicated with pulmonary hypertension (PH) is a leading cause of mortality in congenital diaphragmatic hernia (CDH). Unfortunately, CDH patients are often resistant to PH therapy. Using the nitrofen CDH rat model, we previously demonstrated that CDH-associated PVD involves an induction of elastase and matrix metalloproteinase (MMP) activities, increased osteopontin and epidermal growth factor (EGF) levels, and enhanced smooth muscle cell (SMC) proliferation. Here, we aimed to determine whether the levels of the key members of this proteinase-induced pathway are also elevated in the pulmonary arteries (PAs) of CDH patients.
Source: www.jpedsurg.orgCategories: General Medicine News, General HCPsTweet-
Increased Elastase and Matrix Metalloproteinase Levels in the Pulmonary Arteries of Infants with Congenital Diaphragmatic Hernia #some4pedsurg #some4surgery #CDH https://t.co/kgf58brsxS
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Mashup Score: 11
Background: Congenital Diaphragmatic Hernia (CDH) is a rare developmental abnormality of the diaphragm with an incidence of approximately 2.5 cases per 10,000 births. Despite advances in treatment, mortality and long-term morbidity among survivors remain high. Case Presentation: A newborn was delivered by planned caesarean section due to prenatal diagnosis of CDH, diagnosed at 18 weeks and 5 days (Correction 3.1) during routine ultrasound. The Observed-to-Expected (O/E) Lung area-to-Head circumference Ratio (LHR) was 52%. After birth, the newborn was in respiratory distress and required mechanical invasive ventilation. Surgical repair was planned after stabilisation for the second day of life. A subcostal laparotomy was performed, and an anteromedial hernia with mostly small intestine, the left colon flexure and the spleen as content was found. The abdominal contents were reduced, and the hernia was repaired with a suture. Due to the development of a severe pulmonary hypertension, extu
Source: ijp.mums.ac.irCategories: General Medicine News, General HCPsTweet-
Congenital Diaphragmatic Hernia: A Case Report and Literature Review #some4pedsurg #some4surgery #CDH https://t.co/tz6xhHwQxB
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Exploring Dysphagia in Congenital Diaphragmatic Hernia: A Retrospective Analysis #some4pedsurg #some4surgery #CDH https://t.co/RxeFzLcFaI