• Mashup Score: 4

    Better preparation, listening to the science and acting together in solidarity, are some of the main ways that countries across the world can overcome the on-going COVID-19 crisis, the UN chief told the World Health Summit on Sunday.

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    • “Better preparation, listening to the #science and acting together in #solidarity, are some of the main ways that countries across the world can overcome the on-going #COVID19 crisis” @antonioguterres https://t.co/SQMTXIP08D https://t.co/T91HkFSa7R

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    Critics said the study, sponsored by the W.H.O., was too poorly conducted to be definitive.

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    • Interesting takes on #solidarity trial led by ⁦@WHO⁩ ⁦ Headline fails to note some questioning elements of the design & quality by design execution. ⁦@PCH_SF⁩ Highlights importance of peer review to sort issues +going beyond the headline https://t.co/0aA5qQc3MG

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    BACKGROUND WHO expert groups recommended mortality trials in hospitalized COVID-19 of four re-purposed antiviral drugs. METHODS Study drugs were Remdesivir, Hydroxychloroquine, Lopinavir (fixed-dose combination with Ritonavir) and Interferon-β1a (mainly subcutaneous; initially with Lopinavir, later not). COVID-19 inpatients were randomized equally between whichever study drugs were locally…

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    • Tweet 2/2: Link to preprint of #WHO #SOLIDARITY trial in hospitalized patients with #COVID19 is here: https://t.co/QnSTnO8YbK

  • Mashup Score: 44

    Japan’s health ministry said on Tuesday it planned to participate in the World Health Organization’s COVID-19 vaccine programme known as COVAX.

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    • Thank you #Japan for joining the COVAX facility. @WHO and partners, including @gavi and @CEPIvaccines, welcome your commitment. Only together can we beat #COVID19 and save lives. #Solidarity https://t.co/EVwPTUur9t

  • Mashup Score: 19

    Three issues are crucial in planning COVID-19 vaccine trials: (1) whether to demand not only proof of some vaccine efficacy but also proof of worthwhile efficacy; (2) whether the initial trials of vaccine against placebo should prioritise not only single-vaccine trials but also a multivaccine trial; and (3) whether to assess safety, protection against severe disease, and duration of protection by…

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    • RT @doctorsoumya: https://t.co/60QaQ4GxOf @WHO #Solidarity trial aims to test multiple candidates in a global collaboration @J…

  • Mashup Score: 12

    WHO today accepted the recommendation from the Solidarity Trial’s International Steering Committee to discontinue the trial’s hydroxychloroquine and lopinavir/ritonavir arms. The Solidarity Trial was established by WHO to find an effective COVID-19 treatment for hospitalized patients. The International Steering Committee formulated the recommendation in light of the evidence for…

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    • The @WHO has accepted rec of #SOLIDARITY trial data monitoring committee. Will immed discontinue hydroxychloroquine & lopinavir/ritonavir tx groups: min/no mortality benefit in hospitalized pts w/ #COVID19 compared to std of care. Paper to follow. https://t.co/IWsu0KmTLs

  • Mashup Score: 1

    The World Health Organization announced Wednesday that clinical trials of the drug hydroxychloroquine will resume as it searches for potential coronavirus treatments.

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    • World Health Organization resumes #hydroxychloroquine #RCT #SOLIDARITY after reviewing safety data and assessing concerns about data integrity in related observational studies @NEJM and ⁦@TheLancet. #COVID19 ⁩ https://t.co/yd57Lx15uW