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Mashup Score: 9
Our body’s most outward facing epithelial barrier, the skin, serves as the frontline defense against myriad environmental assailants. To combat these motley threats, the skin has evolved a sophisticated immunological arsenal. In this article, I provide an overview of the skin’s complex architecture and the distinct microniches in which immune cells reside and function. I review burgeoning…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2Damage-Associated Molecular Patterns and the Systemic Immune Consequences of Severe Thermal Injury - 4 year(s) ago
Thermal injury is often associated with a proinflammatory state resulting in serious complications. After a burn, the innate immune system is activated with subsequent immune cell infiltration and cytokine production. Although the innate immune response is typically beneficial, an excessive activation leads to cytokine storms, multiple organ failure, and even death. This overwhelming immune…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 12Neuronal Regulation of Cutaneous Immunity - 4 year(s) ago
The skin is innervated by numerous sensory afferent neurons that respond to a diverse array of stimuli ranging from gentle touch to noxious pain. Various features of the immune system—pathogen recognition, secretion of soluble mediators—are shared with the nervous system. This has led to the recognition that neurons share some functions with innate immune cells and have the capacity to recognize…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
One size does NOT fit all: diversifying immune function in the #skin by @DrShrutiNaik @nyugrossman |#BriefReview in #JI_celebratediversity https://t.co/0qeBqosQfg #ReadTheJI #skinimmunology https://t.co/gCYwcM34y3