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Mashup Score: 3Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS - PubMed - 2 year(s) ago
Indoor PM2.5 and cigarette smoke exposure may lead to increased AM BC deposition. Black carbon content in AMs is associated with worse COPD morbidity in current and former smokers, which remained after sensitivity analysis adjusting for cigarette smoke burden. Airway macrophage BC, which …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 3
A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, IV remdesivir and prolonged oral steroids. Twenty days of nirmatrelv …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 1Efficacy of Dupilumab in Patients with Moderate-to-Severe Asthma and Persistent Airflow Obstruction - PubMed - 2 year(s) ago
In patients with uncontrolled moderate-to-severe asthma, treatment with dupilumab facilitates reversal of PAO status and improves clinical outcomes.
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Corticosteroid Responsiveness Following Mepolizumab in Severe Eosinophilic Asthma—A Randomized, Placebo-Controlled Crossover Trial (MAPLE) - 2 year(s) ago
Mepolizumab inhibits IL-5 activity and reduces exacerbation frequency and maintenance oral corticosteroid (OCS) dosage in patients with severe eosinophilic asthma (SEA). Some patients remain dependent on OCS despite anti–IL-5 treatment, suggesting residual corticosteroid-responsive mechanisms.
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Mashup Score: 0Dupilumab Is Effective in Patients With Moderate-to-Severe Uncontrolled GINA-Defined Type 2 Asthma Irrespective of an Allergic Asthma Phenotype - 2 year(s) ago
The Global Initiative for Asthma report recommends consideration of add-on biologics for patients with type 2 inflammation (blood eosinophils ≥150 cells/μL, fractional exhaled nitric oxide [Feno] ≥20 parts per billion or allergic asthma) whose asthma cannot be controlled by high-dose inhaled corticosteroids. In QUEST (NCT02414854), add-on dupilumab versus placebo was efficacious in patients with…
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Mashup Score: 1Staphylococcal sensitization: a correlate of Type 2-High inflammation in children with severe asthma - 2 year(s) ago
Sensitization to Staphylococcus aureus enterotoxin (SE) has been identified to be a risk factor for asthma, but its determinants remain unclear.
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Mashup Score: 0Empagliflozin restores neutropenia and neutrophil dysfunction in a young patient with severe congenital neutropenia type 4 - 2 year(s) ago
Article InfoPublication HistoryAccepted: October 11, 2022Received in revised form: October 8, 2022Received: April 12, 2022Publication stageIn Press Journal Pre-ProofFootnotesConflicts of interest: The authors declare that they have no relevant conflicts of interest.Clinical ImplicationPatients with severe congenital…
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Mashup Score: 0Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA) - PubMed - 2 year(s) ago
This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. …
Source: PubMedCategories: Critical Care, Latest HeadlinesTweet
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Mashup Score: 2
Asthma patients remain susceptible to severe exacerbations even when their condition is seemingly brought under control,1 potentially suggesting an element of disconnect between exacerbations and asthma control. It has recently been shown that combining oscillometry and spirometry measurements of pulmonary function identifies patients with worse asthma control and more frequent severe…
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Mashup Score: 0Lessons Learned From Five Years of Newborn Screening for Severe Combined Immunodeficiency in Israel - 2 year(s) ago
Implementation of newborn screening (NBS) programs for severe combined immunodeficiency (SCID) have advanced the diagnosis and management of affected infants and undoubtedly improved their outcomes. Reporting long-term follow-up of such programs is of great importance.
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#Black #carbon #content in #airway #macrophages is associated with increased #severe #exacerbations and worse #COPD #morbidity in #SPIROMICS #Pulmonary #Lung https://t.co/CD43xUGXhI https://t.co/n2UUPp9LQR