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Mashup Score: 0
Introduction Real-world evidence on the timing and efficacy of enteral nutrition (EN) practices in intensive care unit (ICU) patients with circulatory shock is limited. We hypothesized early EN (EEN), as compared to delayed EN (DEN), is associated with improved clinical outcomes in mechanically ventilated (MV) patients with circulatory shock. Methods We analyzed a dataset from an international,…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet
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Mashup Score: 1Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial - Critical Care - 2 year(s) ago
Background Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess EDITOR’S PICK https://t.co/Kh89E7c0Oa #AUXORA + #CORTICOSTEROIDS: A NEW STANDARD OF CARE IN SEVERE #COVID_19 #PNEUMONIA? #FOAMed #FOAMcc #BMC #ICU #lung #respiratory_failure #ARDS #cytokine #calcium_channel #immunology #Sars_CoV2 @jlvincen @ISICEM https://t.co/O7goK0hhvs
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Mashup Score: 10
Background Increasing evidence indicates the potential benefits of restricted fluid management in critically ill patients. Evidence lacks on the optimal fluid management strategy for invasively ventilated COVID-19 patients. We hypothesized that the cumulative fluid balance would affect the successful liberation of invasive ventilation in COVID-19 patients with acute respiratory distress syndrome…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess The potential benefits of restricted #fluid management in critically ill patients https://t.co/rM6FWlQTsk @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #Ventilation #ARDS #respiratory_failure https://t.co/tydUqrfAAx
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Mashup Score: 0
Background Whether prone position (PP) improves clinical outcomes in COVID-19 pneumonia treated with noninvasive ventilation (NIV) is unknown. We evaluated the effect of early PP on 28-day NIV failure, intubation and death in noninvasively ventilated patients with moderate-to-severe acute hypoxemic respiratory failure due to COVID-19 pneumonia and explored physiological mechanisms underlying…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Does #prone position improve clinical outcomes in #COVID_19 #pneumonia treated with noninvasive #ventilation? https://t.co/E6nIMdwqt2 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #ARDS #respiratory_failure #Sars_Cov2 https://t.co/IwuRmNRMwZ
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Mashup Score: 1Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial - Critical Care - 2 year(s) ago
Background Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess EDITOR’S PICK https://t.co/Kh89E6UppA #AUXORA + #CORTICOSTEROIDS: A NEW STANDARD OF CARE IN SEVERE #COVID_19 #PNEUMONIA? #FOAMed #FOAMcc #BMC #ICU #lung #respiratory_failure #ARDS #cytokine #calcium_channel #immunology #Sars_CoV2 @jlvincen @ISICEM https://t.co/240VGtOybE
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Mashup Score: 0Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial - Critical Care - 2 year(s) ago
Background Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess EDITOR’S PICK https://t.co/Kh89E7c0Oa #AUXORA + #CORTICOSTEROIDS: A NEW STANDARD OF CARE IN SEVERE #COVID_19 #PNEUMONIA? #FOAMed #FOAMcc #BMC #ICU #lung #respiratory_failure #ARDS #cytokine #calcium_channel #immunology #Sars_CoV2 @jlvincen @ISICEM https://t.co/YKPE3eGd52
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Mashup Score: 2
Background High-flow nasal cannula (HFNC) can improve ventilatory function in patients with acute COPD exacerbation. However, its effect on clinical outcomes remains uncertain. Methods This randomized controlled trial was conducted from July 2017 to December 2020 in 16 tertiary hospitals in China. Patients with acute COPD exacerbation with mild hypercapnia (pH ≥ 7.35 and arterial partial pressure…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Does #High_flow_nasal_cannula improve #ventilatory function in patients with acute #COPD? https://t.co/316gs7AX62 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #HFNC #respiratory_failure #Hypercapnia #Pulmonary_disease #Chronic_obstructive https://t.co/A7NG8e4m4D
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Mashup Score: 2
Background We aimed to assess the efficacy of a closed-loop oxygen control in critically ill patients with moderate to severe acute hypoxemic respiratory failure (AHRF) treated with high flow nasal oxygen (HFNO). Methods In this single-centre, single-blinded, randomized crossover study, adult patients with moderate to severe AHRF who were treated with HFNO (flow rate ≥ 40 L/min with FiO2 ≥ 0.30)…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Closed-loop #oxygen control improves oxygen administration in patients with moderate-to-severe #AHRF treated with #HFNO https://t.co/A3ZohFlAu1 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #ARDS #respiratory_failure #nasal_flow https://t.co/fKVd7QsrS4
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Mashup Score: 27
Background Prone positioning in combination with the application of low tidal volume and adequate positive end-expiratory pressure (PEEP) improves survival in patients with moderate to severe acute respiratory distress syndrome (ARDS). However, the effects of PEEP on end-expiratory transpulmonary pressure (Ptpexp) during prone positioning require clarification. For this purpose, the effects of…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #Prone_positioning (#APP) in the ICU: which factors are associated with success? https://t.co/tL5iRnL1JZ https://t.co/Lo3sJmcH1q @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #oxygenation #ARDS #COVID19 #respiratory_failure https://t.co/FvntnLIFG4
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Mashup Score: 0
Background Whether respiratory efforts and their timing can be reliably detected during pressure support ventilation using standard ventilator waveforms is unclear. This would give the opportunity to assess and improve patient–ventilator interaction without the need of special equipment. Methods In 16 patients under invasive pressure support ventilation, flow and pressure waveforms were obtained…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess EDITOR’S PICK https://t.co/sxN3RmuJ77 #MESENCHYMAL #STROMAL_CELLS: A NEW THERAPEUTIC APPROACH FOR #COVID_19? #FOAMed #FOAMcc #BMC #ICU #Asynchronies #lung #respiratory_failure #ARDS #ventilation @jlvincen @ISICEM https://t.co/P3MDVCV5HX
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#CritCare #OpenAccess Early versus delayed #enteral_nutrition is associated with improved outcomes in mechanically #ventilated_patients with #circulatory_shock https://t.co/WHRZP9uu6b @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #nutrition #respiratory_failure #Vasopressors https://t.co/fSwu3FZTzz