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Mashup Score: 2Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial - Critical Care - 2 year(s) ago
Background Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced acute respiratory distress syndrome (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentially relevant immune-modulatory properties, whose place in ARDS treatment is not established. This phase 2b trial was undertaken to assess the efficacy of UC-MSCs in patients with…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet
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Mashup Score: 3Repeated endo-tracheal tube disconnection generates pulmonary edema in a model of volume overload: an experimental study - Critical Care - 2 year(s) ago
Background An abrupt lung deflation in rodents results in lung injury through vascular mechanisms. Ventilator disconnections during endo-tracheal suctioning in humans often cause cardio-respiratory instability. Whether repeated disconnections or lung deflations cause lung injury or oedema is not known and was tested here in a porcine large animal model. Methods Yorkshire pigs (~ 12 weeks) were…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Rapid #lung #deflations from from high/moderate #PEEP may cause #lung_injury or #oedema https://t.co/H35zcYA9dG @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #ventilation #respiratory_failure https://t.co/UZMNKmwFPB
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Mashup Score: 8Tracheostomy timing and clinical outcomes in ventilated COVID-19 patients: a systematic review and meta-analysis - Critical Care - 2 year(s) ago
Background The association of tracheostomy timing and clinical outcomes in ventilated COVID-19 patients remains controversial. We performed a meta-analysis to evaluate the impact of early tracheostomy compared to late tracheostomy on COVID-19 patients’ outcomes. Methods We searched Medline, Embase, Cochrane, and Scopus database, along with medRxiv, bioRxiv, and Research Square, from December 1,…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Early vs late #tracheostomy on #COVID19 patients’ #outcomes https://t.co/6iQ1HAbAej @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #pandemics #respiratory_failure #pneumonia #ARDS #ventilation https://t.co/GyzdDBtJko
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Mashup Score: 0
Background Non-invasive oxygenation strategies have a prominent role in the treatment of acute hypoxemic respiratory failure during the coronavirus disease 2019 (COVID-19). While the efficacy of these therapies has been studied in hospitalized patients with COVID-19, the clinical outcomes associated with oxygen masks, high-flow oxygen therapy by nasal cannula and non-invasive mechanical…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess High-flow oxygen therapy by #nasal_cannula as primary non-invasive #oxygenation support strategy in critically ill #COVID19 patients https://t.co/ueYxIaCXOY @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #pandemics #respiratory_failure #pneumonia #ARDS https://t.co/SPNf2hWObm
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Mashup Score: 1
Background Extracorporeal membrane oxygenation (ECMO) has become an established rescue therapy for severe acute respiratory distress syndrome (ARDS) in several etiologies including influenza A H1N1 pneumonia. The benefit of receiving ECMO in coronavirus disease 2019 (COVID-19) is still uncertain. The aim of this analysis was to compare the outcome of patients who received veno-venous ECMO for…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Veno-venous #ECMO for #viral #infection associated #ARDS: always the right choice? https://t.co/1JXvAIiULK @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #COVID19 #H1N1 #influenza #virus #lung #pneumonia #respiratory_failure https://t.co/mPRvGCy9At
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Mashup Score: 1
Background Whether respiratory efforts and their timing can be reliably detected during pressure support ventilation using standard ventilator waveforms is unclear. This would give the opportunity to assess and improve patient–ventilator interaction without the need of special equipment. Methods In 16 patients under invasive pressure support ventilation, flow and pressure waveforms were obtained…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess EDITOR’S PICK https://t.co/IYTwIglIjy THE #WAVEFORM METHOD TO DETECT #INSPIRATORY #MUSCLE ACTIVITY DURING #VENTILATION #FOAMed #FOAMcc #BMC #ICU #pneumonia #lung #respiratory_failure #Asynchronies #Respiratory_effort @jlvincen @ISICEM https://t.co/T8Fx5m2wuV
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Mashup Score: 3
Background Whether respiratory efforts and their timing can be reliably detected during pressure support ventilation using standard ventilator waveforms is unclear. This would give the opportunity to assess and improve patient–ventilator interaction without the need of special equipment. Methods In 16 patients under invasive pressure support ventilation, flow and pressure waveforms were obtained…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess The #WAVEFORM METHOD: how to detect the activity of #respiratory_muscles from ventilator waveforms under pressure support #ventilation https://t.co/31yRmo7KNx @jlvincen @ISICEM #FOAMcc #BMC #ICU #Asynchronies #respiratory_failure #Respiratory effort https://t.co/mTzrMyqdfP
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Mashup Score: 1Effects of prone and lateral positioning alternate in high-flow nasal cannula patients with severe COVID-19 - Critical Care - 2 year(s) ago
Research Letter Open Access Published: 25 January 2022 Critical…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Alternating #prone and #lateral position may improve #oxygenation in severe #COVID19 patients https://t.co/TQID19b4jk @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #respiratory_failure #pandemics #Sars_Cov2 https://t.co/NM98LiVWRs
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Mashup Score: 1
Background Whether respiratory efforts and their timing can be reliably detected during pressure support ventilation using standard ventilator waveforms is unclear. This would give the opportunity to assess and improve patient–ventilator interaction without the need of special equipment. Methods In 16 patients under invasive pressure support ventilation, flow and pressure waveforms were obtained…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess EDITOR’S PICK https://t.co/IYTwIglIjy THE #WAVEFORM METHOD TO DETECT #INSPIRATORY #MUSCLE ACTIVITY DURING #VENTILATION #FOAMed #FOAMcc #BMC #ICU #pneumonia #lung #respiratory_failure #Asynchronies #Respiratory_effort @jlvincen @ISICEM https://t.co/kBPN9bg5Ig
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Mashup Score: 11
Question We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae. Materials and methods Prospective cohort of critical COVID-19 patients on IMV. Patients were classified as early intubation if they were intubated within the first 48 h from the…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #COVID19: #Intubation delay is associated with an increase in hospital #mortality and worse #pulmonary sequelae https://t.co/v1JdXIpbJx @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #intubation #respiratory_failure #pneumonia #ARDS #sars_Cov_2 #infection https://t.co/YxLFbHKdrQ
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#CritCare #OpenAccess #COVID19: #Umbilical cord-derived #mesenchymal #stromal #cells have potentially immune-modulatory properties https://t.co/CHaiMgV4z1 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #UC_MSCs #respiratory_failure #ARDS #Sars_Cov2 https://t.co/8BYyGf4UrK