• Mashup Score: 6

    Original Article from The New England Journal of Medicine — Atezolizumab for Advanced Alveolar Soft Part Sarcoma

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    • There is still a great deal of work to be done, but today we celebrate thanks in no small part to the sarcoma investigators of the @NCItreatment’s ETCTN, @bvantine1, @thenasheffect, @geosullivanc, @NaokoTakebe, #AliceChen, #JamesDoroshow & many others! https://t.co/3yVHBzeYk4

    • Thanks to all the investigators and patients who contributed! We were fortunate to work with @genentech & @FDAOncology to obtain FDA approval for this rare population. Approved for patients aged 2 & above thanks to @NCI_CCR_PedOnc & @NCItreatment https://t.co/3yVHBzfw9C

    • This trial was supported by @genentech through a collaborative research and dev agreement (CRADA) with @theNCI, and follows research by the @NCItreatment suggesting a benefit of immunotherapy! This was the first trial we initiated under the CRADA. https://t.co/3yVHBzeYk4

    • We found that 37% of treated patients exhibited a durable and sustained investigator-assessed response, offering meaningful benefit to patients and changing the treatment paradigm for this ultra-rare sarcoma, primarily affecting adolescents & young adults. https://t.co/3yVHBzeYk4

    • Excited to present the results of the @NCICTEP_ClinRes-sponsored trial, 10005, for patients with Alveolar Soft Part Sarcoma (#ASPS) who were treated with the #PDL1 inhibitor, atezolizumab in the @NEJM this week: https://t.co/3yVHBzeYk4

  • Mashup Score: 0
    Oncology Burst - 1 year(s) ago

    FDA approves pembrolizumab as adjuvant treatment for non-small cell lung cancer

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    • 1/2 🔥🚨Hot off the press. @US_FDA approves #Pembrolizumab for #Adjuvant therapy for 1 year (post chemotherapy) for #Patients with resected stage IB, II, IIIA Non-Small Cell #LungCancer (#NSCLC) regardless of #PDL1 level, based on #Keynote 091 study. https://t.co/TGdxNeafrV

  • Mashup Score: 2

    Recommendations for sponsors of investigational new drug applications (INDs) and biologics license applications (BLAs) on the use of pharmacokinetic (PK)-based criteria to support the approval of alternative dosing regimens for PD-1 or PD-L1 blocking antibodies.

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    • Final FDA guidance posted: Pharmacokinetic-Based Criteria for Supporting Alternative Dosing Regimens of Programmed Cell Death Receptor-1 or Programmed Cell Death-Ligand 1 Blocking Antibodies for Treatment of Patients with Cancer https://t.co/esHn1vQpRG #FDAGuidance #PD1 #PDL1 https://t.co/lm5M7AyzxJ