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Mashup Score: 6Atezolizumab for Advanced Alveolar Soft Part Sarcoma | NEJM - 8 month(s) ago
Original Article from The New England Journal of Medicine — Atezolizumab for Advanced Alveolar Soft Part Sarcoma
Source: www.nejm.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Thanks to all the investigators and patients who contributed! We were fortunate to work with @genentech & @FDAOncology to obtain FDA approval for this rare population. Approved for patients aged 2 & above thanks to @NCI_CCR_PedOnc & @NCItreatment https://t.co/3yVHBzfw9C
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This trial was supported by @genentech through a collaborative research and dev agreement (CRADA) with @theNCI, and follows research by the @NCItreatment suggesting a benefit of immunotherapy! This was the first trial we initiated under the CRADA. https://t.co/3yVHBzeYk4
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We found that 37% of treated patients exhibited a durable and sustained investigator-assessed response, offering meaningful benefit to patients and changing the treatment paradigm for this ultra-rare sarcoma, primarily affecting adolescents & young adults. https://t.co/3yVHBzeYk4
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Mashup Score: 0Oncology Burst - 1 year(s) ago
FDA approves pembrolizumab as adjuvant treatment for non-small cell lung cancer
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2
Recommendations for sponsors of investigational new drug applications (INDs) and biologics license applications (BLAs) on the use of pharmacokinetic (PK)-based criteria to support the approval of alternative dosing regimens for PD-1 or PD-L1 blocking antibodies.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Final FDA guidance posted: Pharmacokinetic-Based Criteria for Supporting Alternative Dosing Regimens of Programmed Cell Death Receptor-1 or Programmed Cell Death-Ligand 1 Blocking Antibodies for Treatment of Patients with Cancer https://t.co/esHn1vQpRG #FDAGuidance #PD1 #PDL1 https://t.co/lm5M7AyzxJ
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Mashup Score: 0Immunotherapeutic target could fill unmet need in NSCLC - 1 year(s) ago
Phase 2 clinical trial shows consistent benefits at all levels of PD-L1 expression.
Source: www.mdedge.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Peripheral blood inflammatory indices, like the neutrophil-to-lymphocyte ratio (NLR), may reflect the host’s pro-inflammatory status and systemic immu…
Source: www.sciencedirect.comCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 0Mutation burden predicts ICI response in lung cancer - 2 year(s) ago
Novel biomarker combined with PD-L1 expression could indicate selection of immunotherapy and avoid chemotherapy toxicities in some patients.
Source: www.mdedge.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2PD-L1 Expression in Breast Cancer Brain Metastases - 2 year(s) ago
AbstractBackground. To evaluate potential intracranial efficacy of immunotherapy among patients with breast cancer brain metastases (BrM), we analyzed the immun
Source: OUP AcademicCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 3CRISPR Activation Screening Identifies VGLL3–TEAD1–RUNX1/3 as a Transcriptional Complex for PD-L1 Expression - 2 year(s) ago
The PD-L1/2–PD-1 immune checkpoint is essential for the proper induction of peripheral tolerance and limits autoimmunity, whereas tumor cells exploit their expression to promote immune evasion. Many different cell types express PD-L1/2, either constitutively or upon stimulation, but the factors
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 3LIGHT (TNFSF14) Costimulation Enhances Myeloid Cell Activation and Antitumor Immunity in the Setting of PD-1/PD-L1 and TIGIT Checkpoint Blockade - 2 year(s) ago
This article is featured in Top Reads , p.[][1] [1]: /lookup/volpage/209/429
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0
Original Article from The New England Journal of Medicine — Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer
Source: New England Journal of MedicineCategories: Hem/Oncs, Latest HeadlinesTweet
There is still a great deal of work to be done, but today we celebrate thanks in no small part to the sarcoma investigators of the @NCItreatment’s ETCTN, @bvantine1, @thenasheffect, @geosullivanc, @NaokoTakebe, #AliceChen, #JamesDoroshow & many others! https://t.co/3yVHBzeYk4