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Mashup Score: 16
Nature – IL-33 induces tertiary lymphoid structures.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 16
Nature – IL-33 induces tertiary lymphoid structures.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
1. Tertiary Lymphoid Structures (TLSs) – on demand lymphoid aggregates that assemble in inflamed tissues/cancer to regulate immunity But how? What molecule triggers? What cells induce? TODAY in @Nature https://t.co/vTh33onmjh Long-term #PDAC survivor PART4 – TLSs 🧵1/25
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Mashup Score: 3ARP2/3 complex affects myofibroblast differentiation and migration in pancreatic ductal adenocarcinoma - 30 day(s) ago
Cancer-associated fibroblasts (CAFs) have distinct pro-tumorigenic actions that affect the development and progression of pancreatic ductal adenocarcinoma (PDAC). Here, the authors replicated events …
Source: onlinelibrary.wiley.comCategories: General Medicine News, Oncologists1Tweet-
NOW ONLINE New research highlights the potential of ARP2/3 as new target in treating #PDAC (pancreatic ductal adenocarcinoma). Blocking the ARP2/3 complex slows cancer-associated fibroblasts (CAFs) and improves survival outcome 🔓OPEN ACCESS ➡️https://t.co/PJZD3HhzRm https://t.co/Vcj5pMl1NN
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Mashup Score: 1
Objective Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant immunosuppressive and fibrotic tumour microenvironment (TME). Future therapeutic attempts will therefore demand the targeting of tumours and stromal compartments in order to be effective. Here we investigate whether dual specificity and tyrosine phosphorylation-regulated kinase 1B (DYRK1B) fulfil these criteria and represent a promising anticancer target in PDAC. Design We used transplantation and autochthonous mouse models of PDAC with either genetic Dyrk1b loss or pharmacological DYRK1B inhibition, respectively. Mechanistic interactions between tumour cells and macrophages were studied in direct or indirect co-culture experiments. Histological analyses used tissue microarrays from patients with PDAC. Additional methodological approaches included bulk mRNA sequencing (transcriptomics) and proteomics (secretomics). Results We found that DYRK1B is mainly expressed by pancreatic epithelial
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
RT @MolecularOnco: DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer #PDAC https://t.co/bkbysuhPc6
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Mashup Score: 0FDA Fast Tracks Novel Dendritic Cell Vaccine for Pancreatic Cancer - 6 month(s) ago
A dendritic cell vaccine called DOC1021 shows early promise in treating pancreatic cancer and has received a fast track designation from the FDA.
Source: www.targetedonc.comCategories: General Medicine News, Oncologists1Tweet-
The FDA has granted a fast track designation for DOC1021 for the treatment of pancreatic ductal adenocarcinoma. #PDAC https://t.co/XqF103PtPP
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Mashup Score: 0FDA Fast Tracks Novel Dendritic Cell Vaccine for Pancreatic Cancer - 6 month(s) ago
A dendritic cell vaccine called DOC1021 shows early promise in treating pancreatic cancer and has received a fast track designation from the FDA.
Source: www.targetedonc.comCategories: General Medicine News, Oncologists1Tweet-
The FDA has granted a fast track designation for DOC1021 for the treatment of pancreatic ductal adenocarcinoma. #PDAC https://t.co/XqF103PtPP
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Mashup Score: 1
Objective The optimal therapeutic response in cancer patients is highly dependent upon the differentiation state of their tumours. Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer that harbours distinct phenotypic subtypes with preferential sensitivities to standard therapies. This study aimed to investigate intratumour heterogeneity and plasticity of cancer cell states in PDA in order to reveal cell state-specific regulators. Design We analysed single-cell expression profiling of mouse PDAs, revealing intratumour heterogeneity and cell plasticity and identified pathways activated in the different cell states. We performed comparative analysis of murine and human expression states and confirmed their phenotypic diversity in specimens by immunolabeling. We assessed the function of phenotypic regulators using mouse models of PDA, organoids, cell lines and orthotopically grafted tumour models. Results Our expression analysis and immunolabeling analysis show that a mucus productio
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
RT @MolecularOnco: A mucus production programme promotes classical pancreatic ductal adenocarcinoma #PDAC https://t.co/ren0Iaszvs
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Mashup Score: 4N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance - 7 month(s) ago
Oncogene – N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
A new study identifying a potential avenue to mitigate #PDAC gemcitabine resistance by targeting TGFB2 and lipid metabolism. https://t.co/6yTKx2sWjH
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Mashup Score: 1
Objective The optimal therapeutic response in cancer patients is highly dependent upon the differentiation state of their tumours. Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer that harbours distinct phenotypic subtypes with preferential sensitivities to standard therapies. This study aimed to investigate intratumour heterogeneity and plasticity of cancer cell states in PDA in order to reveal cell state-specific regulators. Design We analysed single-cell expression profiling of mouse PDAs, revealing intratumour heterogeneity and cell plasticity and identified pathways activated in the different cell states. We performed comparative analysis of murine and human expression states and confirmed their phenotypic diversity in specimens by immunolabeling. We assessed the function of phenotypic regulators using mouse models of PDA, organoids, cell lines and orthotopically grafted tumour models. Results Our expression analysis and immunolabeling analysis show that a mucus productio
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
RT @MolecularOnco: A mucus production programme promotes classical pancreatic ductal adenocarcinoma #PDAC https://t.co/ren0Iaszvs
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Mashup Score: 14Fusion genes in pancreatic tumors - 11 month(s) ago
Gene fusions and rearrangements play a crucial role in tumor biology. They are rare events typically detected in KRAS wild-type (WT) pancreatic tumors…
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet-
RT @ArndtVogel: Fusion genes in pancreatic tumors @trendscancer https://t.co/20VGt3sRnQ 👉in 1.4% of #PDAC cases (98% KRAS WT, > acinar neop…
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1. Tertiary Lymphoid Structures (TLSs) – on demand lymphoid aggregates that assemble in inflamed tissues/cancer to regulate immunity But how? What molecule triggers? What cells induce? TODAY in @Nature https://t.co/vTh33onmjh Long-term #PDAC survivor PART4 – TLSs 🧵1/25