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Mashup Score: 53Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer - 2 month(s) ago
Nature Communications – The MAPK pathway is an important therapeutic target in pancreatic ductal adenocarcinoma (PDAC), but success is limited by pathway reactivation, which drives resistance….
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 76
Decoding tumor clonal heterogeneity unravels an unexpected degree of complexity during metastasis formation in pancreatic cancer.
Source: www.science.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 14
Pancreatic cancer carries the highest mortality rate of all major cancers and is projected to become the second-leading cause of cancer-related deaths in the United States by 2030. It is especially difficult …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 112Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis - 2 month(s) ago
Nature Cell Biology – Murthy et al. demonstrate that cancer-associated fibroblast-derived acetate regulates polyamine homeostasis via an ACSS2–SP1–SAT1 axis in pancreatic cancer cells,…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 23A smart molecule beats the mutation behind most pancreatic cancer - 2 month(s) ago
UC San Francisco researchers have designed a candidate drug that could help make pancreatic cancer, which is almost always fatal, a treatable, perhaps even curable, condition.
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 98Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis - 2 month(s) ago
Nature Cell Biology – Murthy et al. demonstrate that cancer-associated fibroblast-derived acetate regulates polyamine homeostasis via an ACSS2–SP1–SAT1 axis in pancreatic cancer cells,…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 18Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression - 2 month(s) ago
Pancreatic ductal adenocarcinoma explant models reveal that malignant epithelial cells induce Hedgehog signaling in fibroblasts that leads to inhibition of noncanonical WNT signaling and VEGFR2-dependent endothelial hypersprouting.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 26Studying the intersection of obesity and pancreatic cancer to unlock early warning signs - 2 month(s) ago
A cancer researcher’s unique lab @OSUCCC_James is studying the intersection of obesity and pancreatic disease to improve outcomes for pancreatic cancer.
Source: health.osu.eduCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 33Machine learning links T-cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer - 2 month(s) ago
Abstract. Tumor molecular datasets are becoming increasingly complex, making it nearly impossible for humans alone to effectively analyze them. Here, we demonstrate the power of using machine learning (ML) to analyze a single-cell, spatial, and highly multiplexed proteomic dataset from human pancreatic cancer and reveal underlying biological mechanisms that may contribute to clinical outcome. We designed a multiplex immunohistochemistry antibody panel to compare T-cell functionality and spatial localization in resected tumors from treatment-naive patients with localized pancreatic ductal adenocarcinoma (PDAC) with resected tumors from a second cohort of patients treated with neoadjuvant agonistic CD40 (anti-CD40) monoclonal antibody therapy. In total, nearly 2.5 million cells from 306 tissue regions collected from 29 patients across both cohorts were assayed, and over 1,000 tumor microenvironment (TME) features were quantified. We then trained ML models to accurately predict anti-CD40
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 18Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression - 3 month(s) ago
Pancreatic ductal adenocarcinoma explant models reveal that malignant epithelial cells induce Hedgehog signaling in fibroblasts that leads to inhibition of noncanonical WNT signaling and VEGFR2-dependent endothelial hypersprouting.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
From the @SitemanCenter #PancreaticCancer SPORE team: Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer https://t.co/wZvte5pMwx Bring on the Enhertu! @DeNardoLabWUSM https://t.co/rtyzpzfchG