-
Mashup Score: 10A Galectin-9–Driven CD11chigh Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia - 3 month(s) ago
BACKGROUND: Preeclampsia is a serious disease of pregnancy that lacks early diagnosis methods or effective treatment, except delivery. Dysregulated uterine immune cells and spiral arteries are implic
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet
-
Mashup Score: 82Injury incidence and prevalence in elite short-course triathletes: a 4-year prospective study - 3 month(s) ago
Objective To characterise the prevalence, incidence rate (IR) and burden of injuries in elite short-course triathletes over a 4-year training and competition period. Methods Fifty elite Australian triathletes were prospectively monitored for injury during four consecutive seasons (2018–2021). Injuries requiring medical attention were prospectively recorded and further subcategorised according to time loss. The IR and burden (injury IR×mean injury severity) were calculated per 365 athlete days, with sex differences in IR compared using IR ratios (IRR) from negative binomial regression models. Results Two hundred and sixty-six injuries were reported in 46 (92.0%) athletes, of which 67.3% resulted in time loss. The injury IR was 1.87 injuries per 365 athlete days (95% CI 1.70 to 2.80), and comparable between sexes (IRR 0.82, 95% CI 0.64 to 1.04, p=0.109). Most injuries (70.7%) were training related. The most frequently injured body sites were the ankle (15.8%), foot (12.4%) and lower leg
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet-
⚠️ Injury incidence and prevalence in elite short-course triathletes 📄 NEW #OriginalResearch 🏊♀️ Females 3x ⬆️ rate of bone stress injury than males 🚴♂️ Bone stress injury = highest injury burden - prevention priority 🏃♀️ Most injuries during training 👉 https://t.co/ZGOEbPTH04 https://t.co/yCrHm2Ko6B
-
-
Mashup Score: 42Differences in injury and concussion rates in a cohort of Canadian female and male youth Rugby Union: a step towards targeted prevention strategies - 3 month(s) ago
Objective To examine differences in match and training musculoskeletal injury and concussion rates and describe mechanisms of concussion while considering previous playing experience in female and male Canadian high school Rugby Union (‘rugby’) players. Methods A 2-year prospective cohort study was completed in a high school league (n=361 females, 421 player-seasons; n=429 males, 481 player-seasons) in Calgary, Canada over the 2018 and 2019 rugby playing seasons. Baseline testing was completed at the start of each season and injury surveillance and individual player participation through session attendance was documented to quantify individual-level player exposure hours. Injury incidence rates (IRs) and incidence rate ratios (IRRs) were calculated using Poisson regression, offset by player exposure hours and clustered by team. Results Overall match IR for females was 62% higher than males (overall IRR=1.62, 95% CI: 1.20 to 2.18) and the overall training IR was twice as high for female
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 4Effect of Mavacamten in Women Compared With Men With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM - 3 month(s) ago
BACKGROUND: Compared with men, women with hypertrophic cardiomyopathy (HCM) have a higher incidence of heart failure and worse outcomes. We investigated baseline clinical and echocardiographic charac
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet
-
Mashup Score: 81Injury incidence and prevalence in elite short-course triathletes: a 4-year prospective study - 3 month(s) ago
Objective To characterise the prevalence, incidence rate (IR) and burden of injuries in elite short-course triathletes over a 4-year training and competition period. Methods Fifty elite Australian triathletes were prospectively monitored for injury during four consecutive seasons (2018–2021). Injuries requiring medical attention were prospectively recorded and further subcategorised according to time loss. The IR and burden (injury IR×mean injury severity) were calculated per 365 athlete days, with sex differences in IR compared using IR ratios (IRR) from negative binomial regression models. Results Two hundred and sixty-six injuries were reported in 46 (92.0%) athletes, of which 67.3% resulted in time loss. The injury IR was 1.87 injuries per 365 athlete days (95% CI 1.70 to 2.80), and comparable between sexes (IRR 0.82, 95% CI 0.64 to 1.04, p=0.109). Most injuries (70.7%) were training related. The most frequently injured body sites were the ankle (15.8%), foot (12.4%) and lower leg
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet-
⚠️ Injury incidence and prevalence in elite short-course triathletes 📄 NEW #OriginalResearch 🏊♀️ Females 3x ⬆️ rate of bone stress injury than males 🚴♂️ Bone stress injury = highest injury burden - prevention priority 🏃♀️ Most injuries during training 👉 https://t.co/ZGOEbPTH04 https://t.co/yCrHm2Ko6B
-
-
Mashup Score: 4Effect of Mavacamten in Women Compared With Men With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM - 4 month(s) ago
BACKGROUND: Compared with men, women with hypertrophic cardiomyopathy (HCM) have a higher incidence of heart failure and worse outcomes. We investigated baseline clinical and echocardiographic charac
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet
-
Mashup Score: 24Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease - 4 month(s) ago
BACKGROUND: High circulating levels of Lp(a) (lipoprotein[a]) increase the risk of atherosclerosis and calcific aortic valve disease, affecting millions of patients worldwide. Although atherosclerosi
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet
-
Mashup Score: 14Associations between cardiorespiratory fitness in youth and the incidence of site-specific cancer in men: a cohort study with register linkage - 4 month(s) ago
Objectives To assess the associations between cardiorespiratory fitness (CRF) in young men and the incidence of site-specific cancer. Methods A Swedish population-based cohort study with register linkage of men who underwent military conscription in 1968–2005 was undertaken. CRF was assessed by maximal aerobic workload cycle test at conscription. Cox regression models assessed linear associations and included CRF, age, year and site of conscription, body mass index and parental level of education. CRF was also categorised into low, moderate and high for facilitated interpretation and results comparing high and low CRF are reported. Results Primary analyses were performed in 1 078 000 men, of whom 84 117 subsequently developed cancer in at least one site during a mean follow-up of 33 years. Higher CRF was linearly associated with a lower hazard ratio (HR) of developing cancer in the head and neck (n=2738, HR 0.81, 95% CI 0.74 to 0.90), oesophagus (n=689, HR 0.61, 95% CI 0.50 to 0.74), s
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 33Causes of sudden cardiac arrest and death and the diagnostic yield of sport preparticipation screening in children - 4 month(s) ago
Objective Evidence on the increased risk of sports-related sudden cardiac arrest and death (SCA/D) and the potential benefit of cardiovascular preparticipation screening (PPS) in children is limited. We assessed the burden and circumstances of SCA/D and the diagnostic yield of cardiovascular PPS in children aged 8–15 years. Methods Data on the incidence and causes of SCA/D from 2011 to 2020 were obtained from the Veneto region (Italy) sudden death registry, hospital records and local press. During the same period, we assessed the results of annual PPS in 25 251 young competitive athletes aged 8–15 years who underwent 58 185 evaluations (mean 2.3/athlete) in Padua, Italy. Results Over 10 years, 26 SCA/D occurred in children aged 8–15 years in the Veneto region: 6 in athletes (incidence 0.7/100 000/year, all ≥12 years) versus 20 in non-athletes (0.7/100 000/year, 17/20 ≥12 years). In total, 4/6 athletes versus 1/20 non-athletes survived. The cause of SCA/D remained unexplained in four at
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 3Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1 - 4 month(s) ago
BACKGROUND: During the neonatal stage, the cardiomyocyte undergoes a constellation of molecular, cytoarchitectural, and functional changes known collectively as cardiomyocyte maturation to increase m
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
#OriginalResearch CARM1 has been found to play a large role in neonatal development by regulating cardiomyocyte maturation. Deregulation of this process may contribute to the development of subsequent heart disease @HongMa2010 @TiffanyGarbutt @lvriedel https://t.co/7kBU4yTFWq https://t.co/GD6TThXNR4
-
#OriginalResearch: CD11c high macrophages activated by increased galectin-9 suppresses uterine spiral artery remodeling, contributing to preeclampsia. @xingxing_zang https://t.co/bJQl5uhU31