-
Mashup Score: 22Crosstalk between Exercise and Immunotherapy: Current Understanding and Future Directions | Research - 11 day(s) ago
Accumulated evidence highlights that exercise can modulate multiple cytokines, influencing transcriptional pathways, and reprogramming certain metabolic processes, ultimately promoting antitumor immunity and enhancing the efficacy of immune checkpoint …
Source: spj.science.orgCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 58Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma - 2 month(s) ago
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is refractory to immune checkpoint inhibitor therapy. However, intratumoral T-cell infiltration correlates with improved overall …
Source: www.tandfonline.comCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 9Fateful fat: Intra-pancreatic lipids cause pancreatic cancer - 3 month(s) ago
In a Mendelian randomization and prospective cohort study, intra-pancreatic fat increases the risk of pancreatic cancer. This provides persuasive human evidence of causal relation between lipids and cancer in the pancreas, which confirms a prediction of the PANDORA hypothesis.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 49Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis - 3 month(s) ago
Nature Cancer – Schmid and colleagues show that pancreatic cancer cell colonization of the liver is accompanied by low-grade tissue injury and efferocytosis, which promotes reprogramming of…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
New #OpenAccess in @NatureCancer from @M_C_Schmid @LivUni Efferocytosis reprograms the tumor microenvironment to promote #PancreaticCancer liver metastasis https://t.co/za4dZM27An Beautiful summary graphic and TONS of functional genetic data that drills down on the fundamental… https://t.co/8KT0J7hZur https://t.co/eUdS5l4bo2
-
-
Mashup Score: 49Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis - 3 month(s) ago
Nature Cancer – Schmid and colleagues show that pancreatic cancer cell colonization of the liver is accompanied by low-grade tissue injury and efferocytosis, which promotes reprogramming of…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
New #OpenAccess in @NatureCancer from @M_C_Schmid @LivUni Efferocytosis reprograms the tumor microenvironment to promote #PancreaticCancer liver metastasis https://t.co/za4dZM27An Beautiful summary graphic and TONS of functional genetic data that drills down on the fundamental… https://t.co/8KT0J7hZur https://t.co/eUdS5l4bo2
-
-
Mashup Score: 47Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis - 3 month(s) ago
Nature Cancer – Schmid and colleagues show that pancreatic cancer cell colonization of the liver is accompanied by low-grade tissue injury and efferocytosis, which promotes reprogramming of…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
New #OpenAccess in @NatureCancer from @M_C_Schmid @LivUni Efferocytosis reprograms the tumor microenvironment to promote #PancreaticCancer liver metastasis https://t.co/za4dZM27An Beautiful summary graphic and TONS of functional genetic data that drills down on the fundamental… https://t.co/8KT0J7hZur https://t.co/eUdS5l4bo2
-
-
Mashup Score: 89An alternative splicing signature defines the basal-like phenotype and predicts worse clinical outcome in pancreatic cancer - 3 month(s) ago
Ruta et al. uncover a splicing signature that identifies molecularly and clinically distinct PDAC phenotypes, highlighting the splicing factor QKI as a marker of the basal-like subtype. They further show that QKI establishes a quasi-mesenchymal splicing pattern contributing to chemoresistance and adaptability to environmental changes in PDAC cells and organoids.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet-
#OpenAccess in @CellRepMed An alternative splicing signature defines the basal-like phenotype and predicts worse clinical outcome in #PancreaticCancer From Claudio Sette et al @Unicatt https://t.co/bLzhk812FI This study implicates Quaking (QKI) as as as key determinant of… https://t.co/CHchZHKJT9 https://t.co/RQpuf2xWXE
-
-
Mashup Score: 26
Background Pancreatic cancer is one of the deadliest cancer types and represents a major unmet medical need. CheckMate 032 investigated safety and efficacy of nivolumab monotherapy and nivolumab plus ipilimumab with/without cobimetinib in advanced/metastatic solid tumors, including pancreatic cancer. Methods In the original pancreatic cancer cohort, previously treated patients (≥1 prior regimen) with advanced/metastatic pancreatic adenocarcinoma were assigned to nivolumab 3 mg/kg every 2 weeks (monotherapy arm) or nivolumab 1 mg/kg and ipilimumab 1 mg/kg or 3 mg/kg every 3 weeks for four doses, followed by nivolumab 3 mg/kg every 2 weeks (combination arm). A subsequent modified pancreatic cohort (one or two prior regimens) received nivolumab 3 mg/kg every 2 weeks, ipilimumab 1 mg/kg every 6 weeks, and cobimetinib 60 mg orally once daily for 21 days on and 7 days off (triplet arm). The primary endpoint was investigator-assessed objective response rate (ORR). Secondary endpoints were inv
Source: jitc.bmj.comCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 98Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells - 3 month(s) ago
Radiotherapy brings immunotherapy-induced effector T cells closer to tumor cells, which is associated with prolonged survival.
Source: www.science.orgCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 36Cytidine deaminase resolves replicative stress and protects pancreatic cancer from DNA-targeting drugs - 3 month(s) ago
Abstract. Cytidine deaminase (CDA) functions in the pyrimidine salvage pathway for DNA and RNA synthesis and has been shown to protect cancer cells from deoxycytidine-based chemotherapies. In this study, we observed that CDA was overexpressed in pancreatic adenocarcinoma from patients at baseline and was essential for experimental tumor growth. Mechanistic investigations revealed that CDA localized to replication forks where it increased replication speed, improved replication fork restart efficiency, reduced endogenous replication stress, minimized DNA breaks, and regulated genetic stability during DNA replication. In cellular pancreatic cancer models, high CDA expression correlated with resistance to DNA-damaging agents. Silencing CDA in patient-derived primary cultures in vitro and in orthotopic xenografts in vivo increased replication stress and sensitized pancreatic adenocarcinoma cells to oxaliplatin. This study sheds light on the role of CDA in pancreatic adenocarcinoma, offerin
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
An #OpenAccess commentary on the Crosstalk between Exercise and Immunotherapy https://t.co/HJ55WIaqmj Leads off with data from @BarDafna @emmakurz paper in #PancreaticCancer https://t.co/yzQyPAKvgQ https://t.co/LNXU1Iow6S