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Mashup Score: 0Imaging in inflammatory arthritis: progress towards precision medicine - Nature Reviews Rheumatology - 7 month(s) ago
In this Perspective, the authors discuss select examples of advancements in high-resolution imaging, functional molecular imaging and artificial intelligence-based analysis that hold promise for addressing current imaging limitations, enabling earlier diagnosis, improved monitoring and ultimately, personalized patient management.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1Inflammation across tissues: can shared cell biology help design smarter trials? - Nature Reviews Rheumatology - 7 month(s) ago
Similarities in the pathogenesis and treatment of immune-mediated inflammatory diseases suggest that they can be investigated together in basket trials, to reduce the risk of failure of early-phase drug development and to facilitate the study of rare diseases.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 7
Lack of understanding of the immunology of sarcoidosis has limited therapeutic progress. However, evidence from a small open-label trial suggests that treatment with the Janus kinase inhibitor tofacitinib can improve sarcoidosis symptoms, predominantly by inhibiting type 1 immunity.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0
In this Review, the authors summarize and discuss regional differences in the prevalence and incidence of rheumatoid arthritis (RA), and describe temporal trends associated with the disease as well as evidence related to risk factors.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1Emerging concepts of type I interferons in SLE pathogenesis and therapy - Nature Reviews Rheumatology - 2 year(s) ago
In this Review, Psarras, Wittmann and Vital discuss evidence of the production of type I interferons by cells and tissues other than haematopoietic cells. These interferons can have local effects, and their roles in the pathogenesis of systemic lupus erythematosus suggest the value of interferon-blocking therapies for treatment of this condition.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 2Kawasaki disease and MIS-C share a host immune response - Nature Reviews Rheumatology - 2 year(s) ago
Multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease are both hyperinflammatory disorders associated with infectious diseases, but are they distinct syndromes or do they exist along a continuum? A comparison of the host immune response in these illnesses provides surprising new insights.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1Genetics of ANCA-associated vasculitis: role in pathogenesis, classification and management - Nature Reviews Rheumatology - 2 year(s) ago
In this Review, the authors summarize the genetic factors associated with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). They describe the findings from genetic association studies, their pathogenic significance and their implications for the classification, management and prognosis of AAV.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1Critical appraisal of serum urate targets in the management of gout - Nature Reviews Rheumatology - 2 year(s) ago
Gout can be effectively treated with long-term urate-lowering therapy. Current guidelines advocate the use of a treat-to-target serum urate strategy, with a target serum urate concentration of <5 mg/dl (<0.30 mmol/l) or <6 mg/dl (<0.36 mmol/l), but specific targets are under debate. In this Review, the authors consider the rationale and evidence for the recommendations.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1Nature Reviews Rheumatology - Volume 18 Issue 10, October 2022 - 2 year(s) ago
Inspired by the Review on p559.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 6Is air pollution linked with poor response to biologics? - Nature Reviews Rheumatology - 3 year(s) ago
Limited data suggest associations between air pollution and rheumatic disease risk and outcomes. More sophisticated research is needed to clarify the conditions under which air pollution might influence the health of people with rheumatic disease, including their response to biologic drugs.
Source: Nature Reviews RheumatologyCategories: Latest Headlines, RheumatologyTweet
#OctoberIssue | In this #Perspective, @Dr_David_Simon and colleagues discuss advances in high-resolution #imaging, functional molecular imaging and #AI-based analysis to improve diagnosis, monitoring and personalized patient management. https://t.co/d9usE1ED7J https://t.co/itpEkWSeKw