• Mashup Score: 0
    Imaging in inflammatory arthritis: progress towards precision medicine - Nature Reviews Rheumatology - 7 month(s) ago

    In this Perspective, the authors discuss select examples of advancements in high-resolution imaging, functional molecular imaging and artificial intelligence-based analysis that hold promise for addressing current imaging limitations, enabling earlier diagnosis, improved monitoring and ultimately, personalized patient management.

    Source: Nature
    Categories: Latest Headlines, Rheumatology
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      NatRevRheumatol

      #OctoberIssue | In this #Perspective, @Dr_David_Simon and colleagues discuss advances in high-resolution #imaging, functional molecular imaging and #AI-based analysis to improve diagnosis, monitoring and personalized patient management. https://t.co/d9usE1ED7J https://t.co/itpEkWSeKw

  • Mashup Score: 7
    Sarcoidosis: can tofacitinib slay the dragon? - Nature Reviews Rheumatology - 2 year(s) ago

    Lack of understanding of the immunology of sarcoidosis has limited therapeutic progress. However, evidence from a small open-label trial suggests that treatment with the Janus kinase inhibitor tofacitinib can improve sarcoidosis symptoms, predominantly by inhibiting type 1 immunity.

    Source: Nature
    Categories: Latest Headlines, Rheumatology
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      NatRevRheumatol

      #OctoberIssue | A lack of understanding of the immunology of #sarcoidosis has limited therapeutic progress. Can the #JAKinib #tofacitinib ‘slay the dragon’? Read more in this #NewsandViews article https://t.co/KCDZMEQaiE

  • Mashup Score: 0
    Global epidemiology of rheumatoid arthritis - Nature Reviews Rheumatology - 2 year(s) ago

    In this Review, the authors summarize and discuss regional differences in the prevalence and incidence of rheumatoid arthritis (RA), and describe temporal trends associated with the disease as well as evidence related to risk factors.

    Source: Nature
    Categories: Latest Headlines, Rheumatology
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      #OctoberIssue | Global #epidemiology of #RheumatoidArthritis Read about the prevalence and incidence of rheumatoid #arthritis, as well as temporal trends and risk factors, in this #Review https://t.co/xjic4Qq79p

  • Mashup Score: 1
    Emerging concepts of type I interferons in SLE pathogenesis and therapy - Nature Reviews Rheumatology - 2 year(s) ago

    In this Review, Psarras, Wittmann and Vital discuss evidence of the production of type I interferons by cells and tissues other than haematopoietic cells. These interferons can have local effects, and their roles in the pathogenesis of systemic lupus erythematosus suggest the value of interferon-blocking therapies for treatment of this condition.

    Source: Nature
    Categories: Latest Headlines, Rheumatology
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      #OctoberIssue | Non-haematopoietic cells are an important source of type I interferons and emerging data highlight an important role for interferons in the early phases of #lupus. Learn more about type I #interferons in SLE #pathogenesis in this #Review https://t.co/zf793vAdct

  • Mashup Score: 2
    Kawasaki disease and MIS-C share a host immune response - Nature Reviews Rheumatology - 2 year(s) ago

    Multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease are both hyperinflammatory disorders associated with infectious diseases, but are they distinct syndromes or do they exist along a continuum? A comparison of the host immune response in these illnesses provides surprising new insights.

    Source: Nature
    Categories: Latest Headlines, Rheumatology
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      NatRevRheumatol

      #OctoberIssue | MIS-C and Kawasaki disease are both hyperinflammatory disorders associated with infectious diseases, but are they distinct syndromes or do they exist along a continuum? Read more in this #NewsandViews article https://t.co/DRGMiUmP2t

  • Mashup Score: 1
    Genetics of ANCA-associated vasculitis: role in pathogenesis, classification and management - Nature Reviews Rheumatology - 2 year(s) ago

    In this Review, the authors summarize the genetic factors associated with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). They describe the findings from genetic association studies, their pathogenic significance and their implications for the classification, management and prognosis of AAV.

    Source: Nature
    Categories: Latest Headlines, Rheumatology
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      #OctoberIssue | Ready for some #WeekendReading? This #Review summarizes the #genetic factors associated with ANCA-associated #vasculitis, including their pathogenic significance and implications for the classification, management and prognosis of AAV https://t.co/AYX0Mk0E8i https://t.co/bH60BMDwlk

  • Mashup Score: 1
    Critical appraisal of serum urate targets in the management of gout - Nature Reviews Rheumatology - 2 year(s) ago

    Gout can be effectively treated with long-term urate-lowering therapy. Current guidelines advocate the use of a treat-to-target serum urate strategy, with a target serum urate concentration of <5 mg/dl (<0.30 mmol/l) or <6 mg/dl (<0.36 mmol/l), but specific targets are under debate. In this Review, the authors consider the rationale and evidence for the recommendations.

    Source: Nature
    Categories: Latest Headlines, Rheumatology
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      #OctoberIssue | In this #Review, Lisa Stamp and Nicola Dalbeth consider the rationale and evidence for the treat-to-target (#T2T ) serum urate recommendations in the management of #gout https://t.co/8UyPvwAPqB

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