A 41-year-old woman with type 1 diabetes admitted with SARS-CoV-2 PCR confirmed respiratory failure developed altered mental status. EEG was unrevealing, and CSF showed an elevated protein (110 mg/dL) and normal glucose (159 mg/dL), without pleocytosis or oligoclonal bands and normal IgG index. MRI demonstrated FLAIR hyperintensities in the corpus callosum and periventricular white matter (Figure…

An 18-year-old man with delayed gross motor and language development and congenital glaucoma presented with recurrent seizures since 3 months of age. The seizures were characterized by left focal onset with secondary generalization and complicated by frequent drug noncompliance. Examination revealed a port-wine stain over the face and extremities (Figure, A), bluish-grey discoloration of the eyes…

A 62-year-old woman presented with sudden-onset staggering gait and dysarthria. Neurologic examination revealed truncal and appendicular ataxia in all limbs and cerebellar dysarthria (Video 1), slight slowing of internal right eye rotation during leftward gaze, and left eye nystagmus on abduction. The deep tendon reflexes were normal. Diffusion-weighted imaging showed a high-signal midline lesion…

A 32-year-old man without vascular risk factors presented with acute onset vertigo, swallowing dysfunction, and right-sided weakness. Physical examination revealed the following signs on the left side: Horner syndrome; lower motor neuron 9th, 10th, and 12th cranial nerve palsies; cerebellar limb ataxia; loss of pain and temperature on the face; and loss of fine touch and proprioception on the…