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Mashup Score: 35Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia - 1 month(s) ago
Key PointsLoss of PRC1.1 leads to resistance to menin inhibition through epigenetic reactivation of noncanonical menin targets in AML cell models.PRC1.1-de
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 15Broken brakes: PRC loss foils menin inhibition - 1 month(s) ago
In this issue of Blood, Zhou et al1 uncover a novel mechanism of resistance to menin inhibitors in KMT2A-rearranged (KMT2A-R) leukemias through Polycomb re
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Broken brakes: PRC loss foils menin inhibition https://t.co/eZQuqLVOpO #myeloidneoplasia
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Mashup Score: 21Importance of predicting CML therapy failure - 1 month(s) ago
In this issue of Blood, Zhang et al1 propose a scoring system to predict the risk of treatment failure with tyrosine kinase inhibitors (TKIs) used in the f
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Importance of predicting CML therapy failure https://t.co/AWaNCDWzmf #myeloidneoplasia
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Mashup Score: 19Importance of predicting CML therapy failure - 1 month(s) ago
In this issue of Blood, Zhang et al1 propose a scoring system to predict the risk of treatment failure with tyrosine kinase inhibitors (TKIs) used in the f
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Importance of predicting CML therapy failure https://t.co/AWaNCDWzmf #myeloidneoplasia
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Mashup Score: 2The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia - 2 month(s) ago
Key PointsIn murine AML models, Herc1 modulates nucleoside analog resistance and levels of deoxycitidine kinase, their rate-limiting metabolic enzyme.HERC1
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
In murine AML models, Herc1 modulates nucleoside analog resistance and levels of deoxycitidine kinase, their rate-limiting metabolic enzyme. https://t.co/G2fycihIE1 #myeloidneoplasia https://t.co/SMBqBSA1wC
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Mashup Score: 35Beat-AML 2024 ELN–refined risk stratification for older adults with newly diagnosed AML given lower-intensity therapy - 2 month(s) ago
Key PointsMost (78%) patients aged ≥ 60 years with ND AML treated with LIT are classified as having 2022 ELN adverse risk.The Beat-AML 2024 risk model inco
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
The Beat-AML 2024 risk model incorporates IDH2, KRAS, MLL2, and TP53 to refine risk stratification among patients aged ≥ 60 years given LIT. https://t.co/BOtJbx13V5 #myeloidneoplasia https://t.co/voloapJeyj
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Mashup Score: 57Proposals for revised International Working Group–European LeukemiaNet criteria for anemia response in myelofibrosis - 2 month(s) ago
Key PointsAn international panel of 38 experts and clinical trialists in MF participated in the preparation of the current document.New definitions of tran
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
New definitions of transfusion status, gender-specific hemoglobin thresholds, and criteria for major and minor responses are submitted. https://t.co/4xLkDvAc4I #myeloidneoplasia https://t.co/3xjiUWWoUR
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Mashup Score: 26ERG: the good, the bad, and the ugly - 2 month(s) ago
In this issue of Blood, Zerella et al1 report an autosomal dominant syndrome of bone marrow failure (BMF) and predisposition to hematological malignancies
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
ERG: the good, the bad, and the ugly https://t.co/E2B0z3vAmu #myeloidneoplasia https://t.co/4ATvKs373y
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Mashup Score: 61Impact of TP53 in MDS with isolated del(5q) - 2 month(s) ago
In this issue of Blood, Montoro et al describe the influence of TP53 gene mutations and its allelic burden in the largest cohort of patients with myelodysp
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Impact of TP53 in MDS with isolated del(5q) https://t.co/IetUerJo8l #myeloidneoplasia https://t.co/7ey4rPMZYr
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Mashup Score: 59Impact of TP53 in MDS with isolated del(5q) - 2 month(s) ago
In this issue of Blood, Montoro et al describe the influence of TP53 gene mutations and its allelic burden in the largest cohort of patients with myelodysp
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Impact of TP53 in MDS with isolated del(5q) https://t.co/IetUerJo8l #myeloidneoplasia https://t.co/7ey4rPMZYr
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Loss of PRC1.1 leads to resistance to menin inhibition through epigenetic reactivation of noncanonical menin targets in AML cell models. https://t.co/fUa3ryVtsx #myeloidneoplasia https://t.co/KtlAwO8dng