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Mashup Score: 0
Key PointsTIFAB regulates oxidative phosphorylation in AML stem/progenitor cells.HNF4A, a newly identified downstream target of TIFAB, rescues the metaboli
Source: ashpublications.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 4Role of molecular alterations in transplantation decisions for patients with primary myelofibrosis - 3 day(s) ago
Key PointsPatients with high MIPSS70 scores benefit from transplantation.Patients with intermediate MIPSS70 scores may benefit from transplantation if thei
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Patients with intermediate MIPSS70 scores may benefit from transplantation if their MTSS score is low or intermediate. https://t.co/zdvo6BUYSN #myeloidneoplasia https://t.co/x6sLeMVV0p
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Mashup Score: 5Sequential epigenetic therapy in AML - 20 day(s) ago
In this issue of Blood, Shah et al found that resistance to BRD4/BET inhibition in acute myeloid leukemia (AML) could be attenuated with properly timed inh
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Over a decade ago, the bromodomain and extraterminal (BET) protein BRD4 was identified as a therapeutic target in AML, a disease that is often driven by dysregulated epigenetic and transcriptional regulation. https://t.co/LAemSrgIFM #myeloidneoplasia https://t.co/jqGJntQ0QK
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Mashup Score: 16De-JAKing resistance with CDK7 inhibitors in post-MPN sAML - 25 day(s) ago
The prognosis of secondary acute myeloid leukemia (sAML) cases that arise from advanced myeloproliferative neoplasms (MPNs) is poor. In this issue of Blood
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
De-JAKing resistance with CDK7 inhibitors in post-MPN sAML https://t.co/86XzmNTIQ6 #myeloidneoplasia
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Mashup Score: 27Preclinical efficacy of CDK7 inhibitor–based combinations against myeloproliferative neoplasms transformed to AML - 26 day(s) ago
Key PointsSY-5609 repressed Myc, inhibited cell growth, induced lethality, and depleted protein expressions in post-MPN sAML stem/progenitor cells.SY-5609
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
SY-5609 combined with BET inhibitor reduced in vivo sAML burden and significantly improved survival in xenograft models of post-MPN sAML. https://t.co/CkHWUubRf8 #myeloidneoplasia https://t.co/ZYCy4u8y2B
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Mashup Score: 10Midostaurin shapes macroclonal and microclonal evolution of FLT3-mutated acute myeloid leukemia - 1 month(s) ago
Key PointsFLT3-ITD persists after ICT with and without MIDO in 68% and 87.5% of patients, respectively.The number of initial FLT3-ITD microclones and macro
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
The number of initial FLT3-ITD microclones and macroclones affects the FLT3-ITD persistence rate after MIDO. https://t.co/nuAQvwKLo5 #myeloidneoplasia https://t.co/LiyQOOBt4t
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Mashup Score: 4The E3 ubiquitin ligase MARCH5 promotes mitochondrial fusion and cell-cycle progression in acute myeloid leukemia - 1 month(s) ago
TO THE EDITOR:
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
The E3 ubiquitin ligase MARCH5 promotes mitochondrial fusion and cell-cycle progression in acute myeloid leukemia https://t.co/RufBdy1rgI #myeloidneoplasia https://t.co/RpajpuwOuE
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Mashup Score: 60
BCR::ABL1-negative myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, prefibrotic myelofibrosis, and primary myel
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Current myeloproliferative neoplasm scoring systems for clinical practice https://t.co/FbLM6qv2pI #myeloidneoplasia https://t.co/IOhXmaKGFR
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Mashup Score: 39Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia - 2 month(s) ago
TO THE EDITOR:
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia https://t.co/2yCmd8jAV5 #myeloidneoplasia https://t.co/s684W4m70X
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Mashup Score: 36Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia - 2 month(s) ago
TO THE EDITOR:
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia https://t.co/2yCmd8jAV5 #myeloidneoplasia https://t.co/s684W4m70X
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HNF4A, a newly identified downstream target of TIFAB, rescues the metabolic defects caused by Tifab deletion in AML stem/progenitor cells. https://t.co/Y37BRMPaTj #myeloidneoplasia https://t.co/NUZCt89rn3