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Mashup Score: 0TAp63-Regulated miRNAs Suppress Cutaneous Squamous Cell Carcinoma through Inhibition of a Network of Cell-Cycle Genes - 4 year(s) ago
TAp63 is a p53 family member and potent tumor and metastasis suppressor. Here, we show that TAp63−/− mice exhibit an increased susceptibility to ultraviolet radiation–induced cutaneous squamous cell carcinoma (cuSCC). A human-to-mouse comparison of cuSCC tumors identified miR-30c-2* and miR-497 as underexpressed in TAp63-deficient cuSCC. Reintroduction of these miRNAs significantly inhibited the…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma - 4 year(s) ago
MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis …
Source: PubMed Central (PMC)Categories: Hem/Oncs, Latest HeadlinesTweet-
#MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in #osteosarcoma https://t.co/DmFYDOfvTC
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Mashup Score: 0TAp63-Regulated miRNAs Suppress Cutaneous Squamous Cell Carcinoma through Inhibition of a Network of Cell-Cycle Genes - 4 year(s) ago
TAp63 is a p53 family member and potent tumor and metastasis suppressor. Here, we show that TAp63−/− mice exhibit an increased susceptibility to ultraviolet radiation–induced cutaneous squamous cell carcinoma (cuSCC). A human-to-mouse comparison of cuSCC tumors identified miR-30c-2* and miR-497 as underexpressed in TAp63-deficient cuSCC. Reintroduction of these miRNAs significantly inhibited the…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Davis et al. show that #TAp63, a #p53 family member, is an essential regulator of a novel #microRNAs that can be therapeutically targeted for potent suppression of #CutaneousSquamousCellCarcinoma. @JasonRodencal @MoffittNews https://t.co/u2DN6UBRaa https://t.co/QVe7SxybOE
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Mashup Score: 0Distinguishing Tumor and Stromal Sources of MicroRNAs Linked to Metastasis in Cutaneous Melanoma - 4 year(s) ago
MicroRNA (miRNA) dysregulation in cancer causes changes in gene expression programs regulating tumor progression and metastasis. Candidate metastasis …
Source: www.sciencedirect.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In the new Issue of #TranslationalOncology, Andrew Craig & Colleagues @queensuResearch @QueensPathology discuss how to distinguish #Tumor and #Stromal Sources of #MicroRNAs Linked to #Metastasis in #CutaneousMelanoma https://t.co/0oE6Z17WXp https://t.co/BnjVKpVc6M
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Davis et al show that #TAp63, a #p53 family member, is an essential regulator of a novel #microRNAs that can be therapeutically targeted for potent suppression of #CutaneousSquamousCellCarcinoma. @JasonRodencal @MoffittNews https://t.co/3pDGqhNDhy https://t.co/DmZXyPTgcK