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Mashup Score: 6SD-101 With Immune Checkpoint Inhibition Generates Positive Results in Uveal Melanoma Liver Metastasis - 5 month(s) ago
Treatment with SD-101 distributed via pressure-enabled drug delivery with immune checkpoint inhibition was tolerated and resulted in the depletion of Tregs, M-MDSCs, and M2 macrophages in liver metastases in patients with uveal melanoma.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 4Dr Nathan on the Design of the IMCgp100-202 Trial in Uveal Melanoma - 6 month(s) ago
Paul D. Nathan, MBBS, PhD, FRCP, discusses the design of the phase 3 IMCgp100-202 trial of tebentafusp-tebn in patients with previously untreated, HLA-A*02:01–positive metastatic uveal melanoma, highlighting the key enrollment criteria of the randomized, open-label study.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 1
Omid Hamid, MD, director, Melanoma Program, The Angeles Clinic and Research Institute, Cedars-Sinai, discusses the rationale for a phase 1 trial of fianlimab plus cemiplimab in patients with advanced melanoma who have received prior adjuvant PD-1 inhibitors.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0AHN Cancer Institute Unveils State-of-the-Art Skin Cancer Center at West Penn Hospital - 7 month(s) ago
Allegheny Health Network Cancer Institute unveiled its new, state-of-the-art Skin Cancer Center at West Penn Hospital, featuring a first-in-the-region full-body 3D imaging system that provides custom digital surveillance for skin abnormalities.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 2Neoadjuvant Daromun Elicits RFS Benefit in Locally Advanced, Fully Resectable Melanoma - 7 month(s) ago
Neoadjuvant treatment with intratumoral daromun led to a statistically significant and clinically meaningful improvement in recurrence-free survival compared with surgery alone in patients with locally advanced, fully resectable melanoma, meeting the primary end point of the phase 3 PIVOTAL trial.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 1
The FDA has approved nivolumab (Opdivo) for the adjuvant treatment of adult and pediatric patients 12 years of age and older with completely resected stage IIB or IIC melanoma.
Source: www.onclive.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
The regulatory decision was supported by data from the phase 3 CheckMate76K trial, where patients treated with adjuvant nivolumab experienced a 58% reduction in the risk of recurrence, new primary melanoma, or death vs placebo. @US_FDA #melsm #oncology https://t.co/uX0Tke6kYu https://t.co/sh67hGuqMR
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Mashup Score: 0Neoadjuvant Daromun Meets Primary End Point of RFS in Melanoma - 7 month(s) ago
A trial of intratumoral daromun and surgical resection for the treatment of patients with locally advanced, fully resectable melanoma, showed a clinically meaningful improvement compared with surgery alone.
Source: www.targetedonc.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0FDA Approves Adjuvant Nivolumab for Stage IIB/C Melanoma - 7 month(s) ago
The FDA has approved adjuvant nivolumab to treat completely resected stage IIB/C melanoma.
Source: www.oncnursingnews.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Discussing Rationale for Combination Therapy in Metastatic Melanoma - 7 month(s) ago
During a Targeted Oncology™ Case-Based Roundtable™ event, Hussein A. Tawbi, MD, PhD, and participants discussed which first-line therapy they would recommend for a 78-year-old patient with metastatic melanoma and no BRAF-activating mutation. This is the first of 2 articles based on this event.
Source: www.targetedonc.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4Bempegaldesleukin Plus Nivolumab in Untreated Advanced Melanoma: The Open-Label, Phase III PIVOT IO 001 Trial Results - 7 month(s) ago
PURPOSE Despite marked advances in the treatment of unresectable or metastatic melanoma, the need for novel therapies remains. Bempegaldesleukin (BEMPEG), a pegylated interleukin-2 (IL-2) cytokine prodrug, demonstrated efficacy in the phase II PIVOT-02 trial. PIVOT IO 001 (ClinicalTrials.gov identifier: NCT03635983) is a phase III, randomized, open-label study that builds on the PIVOT-02 results in first-line melanoma. METHODS Patients with previously untreated, unresectable, or metastatic melanoma were randomly assigned 1:1 to receive BEMPEG plus nivolumab (NIVO) or NIVO monotherapy. Primary end points were objective response rate (ORR) and progression-free survival (PFS) by blinded independent central review and overall survival (OS). Secondary and exploratory end points included additional efficacy measures, safety, and pharmacokinetics (PKs) and pharmacodynamics analyses. RESULTS In 783 patients (n = 391, BEMPEG plus NIVO; n = 392, NIVO monotherapy), the median follow-up was 11.6 m
Source: ascopubs.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
SD-101 With Immune Checkpoint Inhibition Generates Positive Results in Uveal Melanoma Liver Metastasis @DrSapnaPatel @MDAndersonNews #melsm https://t.co/Tka2CkfAU0