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    This JAMA Patient Page describes the autosomal dominant genetic disorder of Marfan syndrome and its diagnosis and treatment.

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    • #MarfanSyndrome ➡️Variant in the FBN1 gene ➡️Autosomal dominant FBN1 gene ➡️Involved in formation of fibrillin 1, component of microscopic elastic fibers that provide structural support for tissues & organs 👉🏽https://t.co/Vh8eItIaO3 via @JAMA_current https://t.co/RdnZVa6Kss

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    A 6-month intervention with an exercise target of 10,000 steps per day may slow aortic root dilation in pediatric patients with Marfan syndrome, according to study data published in the Journal of the American Heart Association.“Artic root dissection remains the most life-threatening complication of Marfan syndrome,” Elif Seda Selamet Tierney, MD, pediatric cardiologist at Stanford

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    • A 6-month intervention with an #exercise target of 10,000 steps per day may slow aortic root dilation in pediatric patients with #Marfansyndrome @JAHA_AHA @StanfordMed #cardiotwitter https://t.co/lNyN3tXXyY

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    New data from the Marfan Treatment Trialists suggest effects of the two agents could be additive and that early treatment could potentially delay the need for surgery.

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    • Beta-blockers have long been recommended to prevent aortic dissection associated with #Marfansyndrome, but a new analysis also supports a benefit from ARBs and further suggests that the two agents exert independent effects. #ESCCongress https://t.co/6ZNt6msArq