• Mashup Score: 0

    Home > Payal Kohli > Dr. Kohli on the SELECT Trial: Semaglutide Reduces MACE in Obese Patients With Heart Disease Novo Nordisk recently announced the headline results from the SELECT cardiovascular outcomes trial, which showed that semaglutide, a GLP-1 receptor agonist, reduces major adverse cardiovascular events in overweight or obese adults with cardiovascular disease. DocWire News Medical Lead Dr. Payal Kohli talked about this landmark study and the impact of the findings on the cardiovascular community.

    Tweet Tweets with this article
    • @payalkohlimd discusses the SELECT trial, which demonstrated that #semaglutide reduces #MACE in overweight or obese adults with cardiovascular disease.https://t.co/IGB2vqMWnt #CVD #heartdisease #obesity https://t.co/SgIgm6mR99

  • Mashup Score: 2

    Objectives Cardiovascular event (CVE) risk in rheumatoid arthritis (RA) was increased by glucocorticoids (GC) use. Whether there is a threshold dose and duration of GC use beyond which will increase CVE rate remains controversial. We studied the time-varying effect of GC and its dose on the risk of incident major adverse cardiovascular events (MACE) in patients with RA. Methods Patients with RA without MACE at baseline were recruited from a Hong Kong citywide database from 2006 to 2015 and followed till 2018. The primary outcome was the first occurrence of an MACE. Cox regression and inverse probability treatment weighting analyses with time-varying covariates were used to evaluate the association of GC and MACE, adjusting for demographics, traditional CV risk factors, inflammatory markers and the usage of antirheumatic drugs. Results Among 12 233 RA patients with 105 826 patient-years of follow-up and a mean follow-up duration of 8.7 years, 860 (7.0%) developed MACE. In the time-varyi

    Tweet Tweets with this article
    • #RA pat. wo prior MACE recruited from Hong Kong database from 2006-2015, followed to2018: After controlling for confounding factors use of GC was associated with up to 2fold increased risk of incident #MACE long-term 💔 <5 mg dx no increase CV risk. https://t.co/SjbpjF9tkp https://t.co/RiyIhlh7Rc