-
Mashup Score: 18
Key PointsThe 2-year progression-free survival of 58 patients with T-cell/histiocyte–rich large B-cell lymphoma treated with CD19-CART therapy was 29%.
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
-
Mashup Score: 0Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies - 28 day(s) ago
Key PointsPIK3CA gain and PTEN loss decrease the dependence of MCL cells on BCR signaling and antiapoptotic BCL2.PIK3CA gain and PTEN loss lead to complex
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
PIK3CA gain and PTEN loss lead to complex metabolic rewiring and increased survival of MCL cells under hypoxia. https://t.co/kiStqq1JOR #lymphoidneoplasia https://t.co/3YXuqpBEDg
-
-
Mashup Score: 5Long-noncoding vulnerabilities in MM - 1 month(s) ago
In this issue of Blood, Grillone et al demonstrate that the long noncoding RNA (lncRNA) RP11-350G8.5 negatively regulates the protein kinase RNA-like endop
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Long-noncoding vulnerabilities in MM https://t.co/3UNe61jBhb #lymphoidneoplasia
-
-
Mashup Score: 10A brain organoid/ALL coculture model reveals the AP-1 pathway as critically associated with CNS involvement of BCP-ALL - 1 month(s) ago
Key PointsCerebral organoids mimic critical structures of the human CNS tissue and can be using to investigate CNS leukemia.Using cerebral organoids concom
Source: ashpublications.orgCategories: General Medicine News, Onc News and JournalsTweet-
Using cerebral organoids concomitant to PDX mouse models, we identify the AP-1 pathway as a critical driver of CNS leukemia. https://t.co/wmG3RlpVMO #lymphoidneoplasia https://t.co/yCmbwRKxkX
-
-
Mashup Score: 36Unbalanced MYC break-apart FISH patterns indicate the presence of a MYC rearrangement in HGBCL-DH-BCL2 - 1 month(s) ago
Key PointsUnbalanced MYC break-apart FISH patterns, in which red or green signal is lost, are observed in ∼13% of HGBCL-DH-BCL2 tumors.Balanced and unbalan
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Balanced and unbalanced MYC rearrangements have the same biological consequences and should be reported as positive for rearrangement. https://t.co/iyIjM4MiBT #lymphoidneoplasia https://t.co/Bg01x5KMu1
-
-
Mashup Score: 25Optimizing drug combinations for T-PLL: restoring DNA damage and P53-mediated apoptotic responses - 1 month(s) ago
Key PointsThe inability of T-PLL cells to evoke adequate P53 responses makes them vulnerable to inhibitors of (H)DAC, BCL2, CDK, and MDM2.Pharmacologic gen
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
The inability of T-PLL cells to evoke adequate P53 responses makes them vulnerable to inhibitors of (H)DAC, BCL2, CDK, and MDM2. https://t.co/1Msg1wvsQS #lymphoidneoplasia https://t.co/LiFFaTIErg
-
-
Mashup Score: 6Targeting therapeutic vulnerabilities in T-PLL - 1 month(s) ago
In this issue of Blood, von Jan and colleagues present results from an ex vivo drug screen for T-cell prolymphocytic leukemia (T-PLL), demonstrating select
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Targeting therapeutic vulnerabilities in T-PLL https://t.co/LD4jna4QtL #lymphoidneoplasia https://t.co/ReAsAgGxPE
-
-
Mashup Score: 150FISHing for clarity in double-hit lymphomas - 2 month(s) ago
In this issue of Blood, Collinge and colleagues1 explore the biological basis of unbalanced MYC fluorescence in situ hybridization (FISH) loss patterns (se
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
FISHing for clarity in double-hit lymphomas https://t.co/8DuHO70KWm #lymphoidneoplasia https://t.co/Q6wAotGiTc
-
-
Mashup Score: 134FISHing for clarity in double-hit lymphomas - 2 month(s) ago
In this issue of Blood, Collinge and colleagues1 explore the biological basis of unbalanced MYC fluorescence in situ hybridization (FISH) loss patterns (se
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
FISHing for clarity in double-hit lymphomas https://t.co/8DuHO70KWm #lymphoidneoplasia https://t.co/Q6wAotGiTc
-
-
Mashup Score: 16KDM6A controls immunogenicity in MM - 2 month(s) ago
In this issue of Blood, Dupéré-Richer et al1 show that the histone demethylase KDM6A directly regulates the immunogenicity of multiple myeloma (MM) cells a
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
KDM6A controls immunogenicity in MM https://t.co/gEUki7qVbc #lymphoidneoplasia https://t.co/RTltuoI3qy
-
The 2-year progression-free survival of 58 patients with T-cell/histiocyte–rich large B-cell lymphoma treated with CD19-CART therapy was 29%. https://t.co/8RZPNMWIBF #lymphoidneoplasia https://t.co/Hu2u7xbQpV